Comparison of Aspirin and Copper Aspirinate with Respect to Gastric Mucosal Damage in the Rat
□ The copper salt of aspirin has been compared with aspirin in terms of damage to mucosal tissue. Using a protein-bound dye to highlight erosions, it has been found that copper aspirinate is at least as damaging as aspirin itself. This finding is not in agreement with previously published claims. Co...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1983-12, Vol.72 (12), p.1457-1461 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | Alich, Agnes A. Welsh, Victoria J. Wittmers, Lorentz E. |
| description | □ The copper salt of aspirin has been compared with aspirin in terms of damage to mucosal tissue. Using a protein-bound dye to highlight erosions, it has been found that copper aspirinate is at least as damaging as aspirin itself. This finding is not in agreement with previously published claims. Copper aspirinate produced more widespread superficial erosions and slightly less deep erosions than aspirin alone. Mixtures of the copper(II) ion and aspirin produced results similar to copper aspirinate, suggesting that the hydrolysis products of copper aspirinate, copper(II) ion and aspirin, together may be especially damaging to the mucosa. Copper alone was not damaging, but aspirin alone yielded intermediate results. Short incubation times produced only erosions (no ulcers), which were clearly differentiated into two classes by depth of color. Histological examination verified this classification into superficial and deep erosions. |
| doi_str_mv | 10.1002/jps.2600721222 |
| format | Article |
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Using a protein-bound dye to highlight erosions, it has been found that copper aspirinate is at least as damaging as aspirin itself. This finding is not in agreement with previously published claims. Copper aspirinate produced more widespread superficial erosions and slightly less deep erosions than aspirin alone. Mixtures of the copper(II) ion and aspirin produced results similar to copper aspirinate, suggesting that the hydrolysis products of copper aspirinate, copper(II) ion and aspirin, together may be especially damaging to the mucosa. Copper alone was not damaging, but aspirin alone yielded intermediate results. Short incubation times produced only erosions (no ulcers), which were clearly differentiated into two classes by depth of color. Histological examination verified this classification into superficial and deep erosions.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600721222</identifier><identifier>PMID: 6663486</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Animals ; Aspirin - toxicity ; aspirin and copper aspirinate ; Aspirin-gastric mucosal damage in the rat ; Aspirin—gastric mucosal damage in the rat, protein-bound dye, histology, comparison with copper aspirinate ; Biological and medical sciences ; Buffers ; comparison using protein-bound dye and histology ; comparison with aspirin ; comparison with copper aspirinate ; Copper - toxicity ; Copper aspirinate-gastric mucosal damage in the rat ; Copper aspirinate—gastric mucosal damage in the rat, protein-bound dye, histology, comparison with aspirin ; Drug toxicity and drugs side effects treatment ; Gastric Mucosa - drug effects ; histology ; Male ; Medical sciences ; Pharmacology. Drug treatments ; protein-bound dye ; rat ; Rats ; Rats, Inbred Strains ; Stomach Ulcer - chemically induced ; Toxicity: digestive system ; Ulceration-gastric mucosa ; Ulceration—gastric mucosa, rat, aspirin and copper aspirinate, comparison using protein-bound dye and histology</subject><ispartof>Journal of pharmaceutical sciences, 1983-12, Vol.72 (12), p.1457-1461</ispartof><rights>1983 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1983 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4872-625151bd7c1fda6715f60db5f095485311dd4fa4f829bb249c15ee1e409acb143</citedby><cites>FETCH-LOGICAL-c4872-625151bd7c1fda6715f60db5f095485311dd4fa4f829bb249c15ee1e409acb143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600721222$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600721222$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9647554$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6663486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alich, Agnes A.</creatorcontrib><creatorcontrib>Welsh, Victoria J.</creatorcontrib><creatorcontrib>Wittmers, Lorentz E.</creatorcontrib><title>Comparison of Aspirin and Copper Aspirinate with Respect to Gastric Mucosal Damage in the Rat</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>□ The copper salt of aspirin has been compared with aspirin in terms of damage to mucosal tissue. Using a protein-bound dye to highlight erosions, it has been found that copper aspirinate is at least as damaging as aspirin itself. This finding is not in agreement with previously published claims. Copper aspirinate produced more widespread superficial erosions and slightly less deep erosions than aspirin alone. Mixtures of the copper(II) ion and aspirin produced results similar to copper aspirinate, suggesting that the hydrolysis products of copper aspirinate, copper(II) ion and aspirin, together may be especially damaging to the mucosa. Copper alone was not damaging, but aspirin alone yielded intermediate results. Short incubation times produced only erosions (no ulcers), which were clearly differentiated into two classes by depth of color. Histological examination verified this classification into superficial and deep erosions.</description><subject>Animals</subject><subject>Aspirin - toxicity</subject><subject>aspirin and copper aspirinate</subject><subject>Aspirin-gastric mucosal damage in the rat</subject><subject>Aspirin—gastric mucosal damage in the rat, protein-bound dye, histology, comparison with copper aspirinate</subject><subject>Biological and medical sciences</subject><subject>Buffers</subject><subject>comparison using protein-bound dye and histology</subject><subject>comparison with aspirin</subject><subject>comparison with copper aspirinate</subject><subject>Copper - toxicity</subject><subject>Copper aspirinate-gastric mucosal damage in the rat</subject><subject>Copper aspirinate—gastric mucosal damage in the rat, protein-bound dye, histology, comparison with aspirin</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Gastric Mucosa - drug effects</subject><subject>histology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>protein-bound dye</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Stomach Ulcer - chemically induced</subject><subject>Toxicity: digestive system</subject><subject>Ulceration-gastric mucosa</subject><subject>Ulceration—gastric mucosa, rat, aspirin and copper aspirinate, comparison using protein-bound dye and histology</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1EVZbClRuSD4hbtrbjj_hYtrClKh9qQZWQkOXYE-qSxMHOUvrvmyrLIg6IkyXP845nHiP0jJIlJYQdXg95ySQhilHG2AO0oIKRQhKqHqLFBLCiFFw_Qo9zviaESCLEPtqXUpa8kgv0dRW7waaQY49jg4_yEFLose09XsVhgPT7yo6Ab8J4hc8hD-BGPEa8tnlMweF3GxezbfGx7ew3wFN-vAJ8bscnaK-xbYan2_MAfX7z-tPqpDj7sH67OjorHK8UKyQTVNDaK0cbb6WiopHE16IhWvBKlJR6zxvLm4rpumZcOyoAKHCiraspLw_Qy7nvkOKPDeTRdCE7aFvbQ9xkQzlVlaiqCVzOoEsx5wSNGVLobLo1lJh7n2byaf74nALPt503dQd-h28FTvUX27rNzrZNsr0LeYdpyZUQ9wPqGbsJLdz-51Fz-vHirxGKORvyCL92WZu-G6lKJczl-7U50V_0q0tWmouJr2YeJuM_AySTXYDegQ9p-jjjY_jXtndWMK80</recordid><startdate>198312</startdate><enddate>198312</enddate><creator>Alich, Agnes A.</creator><creator>Welsh, Victoria J.</creator><creator>Wittmers, Lorentz E.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>198312</creationdate><title>Comparison of Aspirin and Copper Aspirinate with Respect to Gastric Mucosal Damage in the Rat</title><author>Alich, Agnes A. ; Welsh, Victoria J. ; Wittmers, Lorentz E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4872-625151bd7c1fda6715f60db5f095485311dd4fa4f829bb249c15ee1e409acb143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Aspirin - toxicity</topic><topic>aspirin and copper aspirinate</topic><topic>Aspirin-gastric mucosal damage in the rat</topic><topic>Aspirin—gastric mucosal damage in the rat, protein-bound dye, histology, comparison with copper aspirinate</topic><topic>Biological and medical sciences</topic><topic>Buffers</topic><topic>comparison using protein-bound dye and histology</topic><topic>comparison with aspirin</topic><topic>comparison with copper aspirinate</topic><topic>Copper - toxicity</topic><topic>Copper aspirinate-gastric mucosal damage in the rat</topic><topic>Copper aspirinate—gastric mucosal damage in the rat, protein-bound dye, histology, comparison with aspirin</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Gastric Mucosa - drug effects</topic><topic>histology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>protein-bound dye</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Stomach Ulcer - chemically induced</topic><topic>Toxicity: digestive system</topic><topic>Ulceration-gastric mucosa</topic><topic>Ulceration—gastric mucosa, rat, aspirin and copper aspirinate, comparison using protein-bound dye and histology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alich, Agnes A.</creatorcontrib><creatorcontrib>Welsh, Victoria J.</creatorcontrib><creatorcontrib>Wittmers, Lorentz E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alich, Agnes A.</au><au>Welsh, Victoria J.</au><au>Wittmers, Lorentz E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Aspirin and Copper Aspirinate with Respect to Gastric Mucosal Damage in the Rat</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1983-12</date><risdate>1983</risdate><volume>72</volume><issue>12</issue><spage>1457</spage><epage>1461</epage><pages>1457-1461</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>□ The copper salt of aspirin has been compared with aspirin in terms of damage to mucosal tissue. Using a protein-bound dye to highlight erosions, it has been found that copper aspirinate is at least as damaging as aspirin itself. This finding is not in agreement with previously published claims. Copper aspirinate produced more widespread superficial erosions and slightly less deep erosions than aspirin alone. Mixtures of the copper(II) ion and aspirin produced results similar to copper aspirinate, suggesting that the hydrolysis products of copper aspirinate, copper(II) ion and aspirin, together may be especially damaging to the mucosa. Copper alone was not damaging, but aspirin alone yielded intermediate results. Short incubation times produced only erosions (no ulcers), which were clearly differentiated into two classes by depth of color. Histological examination verified this classification into superficial and deep erosions.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>6663486</pmid><doi>10.1002/jps.2600721222</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1983-12, Vol.72 (12), p.1457-1461 |
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| subjects | Animals Aspirin - toxicity aspirin and copper aspirinate Aspirin-gastric mucosal damage in the rat Aspirin—gastric mucosal damage in the rat, protein-bound dye, histology, comparison with copper aspirinate Biological and medical sciences Buffers comparison using protein-bound dye and histology comparison with aspirin comparison with copper aspirinate Copper - toxicity Copper aspirinate-gastric mucosal damage in the rat Copper aspirinate—gastric mucosal damage in the rat, protein-bound dye, histology, comparison with aspirin Drug toxicity and drugs side effects treatment Gastric Mucosa - drug effects histology Male Medical sciences Pharmacology. Drug treatments protein-bound dye rat Rats Rats, Inbred Strains Stomach Ulcer - chemically induced Toxicity: digestive system Ulceration-gastric mucosa Ulceration—gastric mucosa, rat, aspirin and copper aspirinate, comparison using protein-bound dye and histology |
| title | Comparison of Aspirin and Copper Aspirinate with Respect to Gastric Mucosal Damage in the Rat |
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