Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat
Using immunohistochemistry evidence was obtained for the coexistence of calcitonin gene-related peptide (CGRP)- and substance P (SP)-like immunoreactivity in spinal sensory neurons. Analysis of caudally directed biting and scratching (CBS) behavior was carried out after intrathecal administration of...
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| Veröffentlicht in: | Neuroscience letters 1984-11, Vol.52 (1), p.199-204 |
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| container_title | Neuroscience letters |
| container_volume | 52 |
| creator | Wiesenfeld-Hallin, Z. Hökfelt, T. Lundberg, J.M. Forssmann, W.G. Reinecke, M. Tschopp, F.A. Fischer, J.A. |
| description | Using immunohistochemistry evidence was obtained for the coexistence of calcitonin gene-related peptide (CGRP)- and substance P (SP)-like immunoreactivity in spinal sensory neurons. Analysis of caudally directed biting and scratching (CBS) behavior was carried out after intrathecal administration of CGRP and SP alone or in combination. Thus, SP (up to 20 μg) alone caused CBS only for a few minutes after injection, whereas SP (10 μg) plus CGRP (20 μg) caused a response with a duration up to 40 min. CGRP (20 μg) alone had no effects in this model. These findings provide support for a possible interaction of the two peptides at synapses in the dorsal horn of the spinal cord. |
| doi_str_mv | 10.1016/0304-3940(84)90374-4 |
| format | Article |
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Analysis of caudally directed biting and scratching (CBS) behavior was carried out after intrathecal administration of CGRP and SP alone or in combination. Thus, SP (up to 20 μg) alone caused CBS only for a few minutes after injection, whereas SP (10 μg) plus CGRP (20 μg) caused a response with a duration up to 40 min. CGRP (20 μg) alone had no effects in this model. These findings provide support for a possible interaction of the two peptides at synapses in the dorsal horn of the spinal cord.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(84)90374-4</identifier><identifier>PMID: 6084836</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Behavior, Animal - drug effects ; behavioral interaction ; Biological and medical sciences ; Calcitonin Gene-Related Peptide ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; coexistence ; Drug Interactions ; Fluorescent Antibody Technique ; Fundamental and applied biological sciences. Psychology ; Male ; Nerve Tissue Proteins - metabolism ; Nerve Tissue Proteins - pharmacology ; Neurons, Afferent - metabolism ; neuropeptides ; rat ; Rats ; Rats, Inbred Strains ; sensory neurons ; Spinal Cord - drug effects ; Spinal Cord - metabolism ; Substance P - metabolism ; Substance P - pharmacology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 1984-11, Vol.52 (1), p.199-204</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-c8c943fab00992642af350d177386e0fed75a7c12bd3ac1fd6dbc6ba286ef5573</citedby><cites>FETCH-LOGICAL-c483t-c8c943fab00992642af350d177386e0fed75a7c12bd3ac1fd6dbc6ba286ef5573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3940(84)90374-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9062106$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6084836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wiesenfeld-Hallin, Z.</creatorcontrib><creatorcontrib>Hökfelt, T.</creatorcontrib><creatorcontrib>Lundberg, J.M.</creatorcontrib><creatorcontrib>Forssmann, W.G.</creatorcontrib><creatorcontrib>Reinecke, M.</creatorcontrib><creatorcontrib>Tschopp, F.A.</creatorcontrib><creatorcontrib>Fischer, J.A.</creatorcontrib><title>Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Using immunohistochemistry evidence was obtained for the coexistence of calcitonin gene-related peptide (CGRP)- and substance P (SP)-like immunoreactivity in spinal sensory neurons. Analysis of caudally directed biting and scratching (CBS) behavior was carried out after intrathecal administration of CGRP and SP alone or in combination. Thus, SP (up to 20 μg) alone caused CBS only for a few minutes after injection, whereas SP (10 μg) plus CGRP (20 μg) caused a response with a duration up to 40 min. CGRP (20 μg) alone had no effects in this model. These findings provide support for a possible interaction of the two peptides at synapses in the dorsal horn of the spinal cord.</description><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>behavioral interaction</subject><subject>Biological and medical sciences</subject><subject>Calcitonin Gene-Related Peptide</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>coexistence</subject><subject>Drug Interactions</subject><subject>Fluorescent Antibody Technique</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Nerve Tissue Proteins - pharmacology</subject><subject>Neurons, Afferent - metabolism</subject><subject>neuropeptides</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>sensory neurons</subject><subject>Spinal Cord - drug effects</subject><subject>Spinal Cord - metabolism</subject><subject>Substance P - metabolism</subject><subject>Substance P - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhS0EKreFNwDJC1TBImAnTpxskFBFoVIlWMDacuwxNUrs4HGu2ufpi-L7o7vsypbOd8bjcwh5w9lHznj3iTVMVM0g2PtefBhYI0UlnpEN72VdyUHWz8nmhLwk54h_GWMtb8UZOetYL_qm25DHm3leQ0ygTfZboEZPxucYfKB_IECVYNIZLF1gyd4C1cFSXEfMOhigP6mJcO8x08IjBIzpgQZYUwxIc6T5DiguPuipgMnu3T5kSOW1veWgjXCntz6mck2ASzED0uj29qTzK_LC6Qnh9fG8IL-vv_66-l7d_vh2c_XltjLlL7kyvRlE4_TI2DDUnai1a1pmuZRN3wFzYGWrpeH1aBttuLOdHU036rqorm1lc0EuD3OXFP-tgFnNHg1Mkw4QV1RclFmyrwsoDqBJETGBU0vys04PijO160btgle74FUv1L4bJYrt7XH-Os5gT6ZjGUV_d9Q1lh5cKhl7PGED62rOdtjnAwYli62HpNB4KHVYn8BkZaN_eo__0Ieutg</recordid><startdate>19841123</startdate><enddate>19841123</enddate><creator>Wiesenfeld-Hallin, Z.</creator><creator>Hökfelt, T.</creator><creator>Lundberg, J.M.</creator><creator>Forssmann, W.G.</creator><creator>Reinecke, M.</creator><creator>Tschopp, F.A.</creator><creator>Fischer, J.A.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19841123</creationdate><title>Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat</title><author>Wiesenfeld-Hallin, Z. ; Hökfelt, T. ; Lundberg, J.M. ; Forssmann, W.G. ; Reinecke, M. ; Tschopp, F.A. ; Fischer, J.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-c8c943fab00992642af350d177386e0fed75a7c12bd3ac1fd6dbc6ba286ef5573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>behavioral interaction</topic><topic>Biological and medical sciences</topic><topic>Calcitonin Gene-Related Peptide</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>coexistence</topic><topic>Drug Interactions</topic><topic>Fluorescent Antibody Technique</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Nerve Tissue Proteins - pharmacology</topic><topic>Neurons, Afferent - metabolism</topic><topic>neuropeptides</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>sensory neurons</topic><topic>Spinal Cord - drug effects</topic><topic>Spinal Cord - metabolism</topic><topic>Substance P - metabolism</topic><topic>Substance P - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wiesenfeld-Hallin, Z.</creatorcontrib><creatorcontrib>Hökfelt, T.</creatorcontrib><creatorcontrib>Lundberg, J.M.</creatorcontrib><creatorcontrib>Forssmann, W.G.</creatorcontrib><creatorcontrib>Reinecke, M.</creatorcontrib><creatorcontrib>Tschopp, F.A.</creatorcontrib><creatorcontrib>Fischer, J.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wiesenfeld-Hallin, Z.</au><au>Hökfelt, T.</au><au>Lundberg, J.M.</au><au>Forssmann, W.G.</au><au>Reinecke, M.</au><au>Tschopp, F.A.</au><au>Fischer, J.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1984-11-23</date><risdate>1984</risdate><volume>52</volume><issue>1</issue><spage>199</spage><epage>204</epage><pages>199-204</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Using immunohistochemistry evidence was obtained for the coexistence of calcitonin gene-related peptide (CGRP)- and substance P (SP)-like immunoreactivity in spinal sensory neurons. Analysis of caudally directed biting and scratching (CBS) behavior was carried out after intrathecal administration of CGRP and SP alone or in combination. Thus, SP (up to 20 μg) alone caused CBS only for a few minutes after injection, whereas SP (10 μg) plus CGRP (20 μg) caused a response with a duration up to 40 min. CGRP (20 μg) alone had no effects in this model. These findings provide support for a possible interaction of the two peptides at synapses in the dorsal horn of the spinal cord.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>6084836</pmid><doi>10.1016/0304-3940(84)90374-4</doi><tpages>6</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1984-11, Vol.52 (1), p.199-204 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Behavior, Animal - drug effects behavioral interaction Biological and medical sciences Calcitonin Gene-Related Peptide Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors coexistence Drug Interactions Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Male Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - pharmacology Neurons, Afferent - metabolism neuropeptides rat Rats Rats, Inbred Strains sensory neurons Spinal Cord - drug effects Spinal Cord - metabolism Substance P - metabolism Substance P - pharmacology Vertebrates: nervous system and sense organs |
| title | Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat |
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