The toxic effects of heavy metals on rat bone marrow in vitro erythropoiesis: Protective role of hemin and zinc

The effects of gold (Au), lead (Pb), and cadmium (Cd) on rat bone marrow in vitro erythropoiesis (CFU E) were studied. Au was found to be significantly toxic to CFU E growth at concentrations as low as 10 −9 m whereas Pb and Cd displayed toxicity at 10 −7 m. Addition of Pb plus Cd in combination had...

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Veröffentlicht in:	Environ. Res.; (United States) 1984-10, Vol.35 (1), p.97-103
Hauptverfasser:	Lutton, J.D., Ibraham, N.G., Friedland, M., Levere, R.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) ANIMAL TISSUES ANIMALS Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL PATHWAYS BLOOD FORMATION BODY BONE MARROW Bone Marrow - drug effects CADMIUM Cadmium - toxicity CARBOXYLIC ACIDS CELL CULTURES Chemical and industrial products toxicology. Toxic occupational diseases COMPARATIVE EVALUATIONS DATA ELEMENTS ERYTHROPOIESIS Erythropoiesis - drug effects EXPERIMENTAL DATA Female GOLD Gold - toxicity HEMATOPOIETIC SYSTEM HEME Heme - analogs & derivatives Hemin - pharmacology HETEROCYCLIC ACIDS HETEROCYCLIC COMPOUNDS In Vitro Techniques INFORMATION INHIBITION LEAD Lead - toxicity MAMMALS Medical sciences METALS Metals and various inorganic compounds NUMERICAL DATA ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANS PIGMENTS PORPHYRINS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS Rats, Inbred Strains RESPONSE MODIFYING FACTORS RODENTS TISSUES TOXICITY Toxicology Trace Elements - toxicity TRANSITION ELEMENTS VERTEBRATES ZINC Zinc - pharmacology
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