Optimization of enzyme catalyzed peptide synthesis in a “water - water-immiscible organic solvent” biphasic system

Optimal conditions were found, for enzymatic synthesis of the dipeptide, N-acetyl-L-tryptophanyl-L-leucine amide in the biphasic system water - ethyl acetate. The synthesis was carried out using both free and. immobilized α-chymotrypsin. Optimization was performed, by such parameters as the “organic...

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Veröffentlicht in:	Tetrahedron 1984, Vol.40 (21), p.4425-4432
Hauptverfasser:	Khmel'Nitski, Yu.L., Dien, Fam Khyu, Semenov, A.N., Martinek, Karel, Veruovič, B., Kubánek, Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha -chymotrypsin Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology immobilized enzymes Methods. Procedures. Technologies N-acetyl-L-tryptophanyl-L-leucine amide peptide synthesis
Online-Zugang:	Volltext
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