Cortisol and depression: three questions for psychiatry

Cortisol plays a multifaceted role in major depression disorder (MDD). Diurnal rhythms are disturbed, there is increased resistance to the feedback action of glucocorticoids, excess cortisol may induce MDD, basal levels may be higher and the post-awakening cortisol surge accentuated in those at risk...

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Veröffentlicht in:	Psychological medicine 2013-03, Vol.43 (3), p.449-469
1. Verfasser:	Herbert, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animals Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Biological and medical sciences Brain - metabolism Brain-Derived Neurotrophic Factor - metabolism Brain-Derived Neurotrophic Factor - physiology Chronobiology Disorders - metabolism Chronobiology Disorders - physiopathology Circadian Rhythm - physiology Clinical management Cognitive ability Cognitive psychology Corticotropin-Releasing Hormone - metabolism Corticotropin-Releasing Hormone - physiology Cortisol Dehydroepiandrosterone - metabolism Dehydroepiandrosterone - physiology Depression Depressive Disorder, Major - drug therapy Depressive Disorder, Major - genetics Depressive Disorder, Major - metabolism Disease Susceptibility Gene Expression Gene-Environment Interaction Hormone Antagonists - therapeutic use Humans Hydrocortisone - metabolism Hydrocortisone - physiology Hypothalamo-Hypophyseal System - physiopathology Medical sciences Mental depression Mifepristone - therapeutic use Mood disorders Neurogenesis - physiology Pituitary-Adrenal System - physiopathology Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Glucocorticoid - antagonists & inhibitors Rhythm Risk Factors Sex Characteristics Sleep disorders Stress, Psychological - metabolism Subtypes Temperament Treatment Outcome Variants
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