A B cell growth factor-like activity is secreted by cloned, neoplastic B cells
Supernatants from synchronized clones of neoplastic B cells (BCL1) were found to contain a B cell growth factor (BCGFI)-like activity. The BCGF activity in the BCL1 supernatants (SN) could synergize with EL-4 SN in the late phases of an IL 1-dependent BCGF I assay (days 5 through 8). These SN did no...
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| Veröffentlicht in: | The Journal of immunology (1950) 1984-12, Vol.133 (6), p.3133-3137 |
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| container_end_page | 3137 |
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| container_issue | 6 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 133 |
| creator | Brooks, KH Uhr, JW Vitetta, ES |
| description | Supernatants from synchronized clones of neoplastic B cells (BCL1) were found to contain a B cell growth factor (BCGFI)-like activity. The BCGF activity in the BCL1 supernatants (SN) could synergize with EL-4 SN in the late phases of an IL 1-dependent BCGF I assay (days 5 through 8). These SN did not contain any detectable BCGF II, IL, 1, or IL 2 activity. In contrast to EL-4-derived BCGF I, which has a m.w. of approximately 18,000, the BCL1-BCGF activity has a m.w. of approximately 4500. Because the BCGF activity in BCL1 SN fluctuates with cell cycle in synchronized cultures, this BCL1-BCGF may play an auto-stimulatory role in B cell proliferation. |
| doi_str_mv | 10.4049/jimmunol.133.6.3133 |
| format | Article |
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The BCGF activity in the BCL1 supernatants (SN) could synergize with EL-4 SN in the late phases of an IL 1-dependent BCGF I assay (days 5 through 8). These SN did not contain any detectable BCGF II, IL, 1, or IL 2 activity. In contrast to EL-4-derived BCGF I, which has a m.w. of approximately 18,000, the BCL1-BCGF activity has a m.w. of approximately 4500. Because the BCGF activity in BCL1 SN fluctuates with cell cycle in synchronized cultures, this BCL1-BCGF may play an auto-stimulatory role in B cell proliferation.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.133.6.3133</identifier><identifier>PMID: 6333454</identifier><identifier>CODEN: JOIMA3</identifier><language>eng</language><publisher>Bethesda, MD: Am Assoc Immnol</publisher><subject>Analysis of the immune response. 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Psychology ; Fundamental immunology ; Growth Substances - isolation & purification ; Growth Substances - metabolism ; Growth Substances - physiology ; Humans ; Immunobiology ; Interleukin-1 - physiology ; Interleukin-4 ; Kinetics ; Lymphocyte Activation ; Lymphokines - isolation & purification ; Lymphokines - metabolism ; Lymphokines - physiology ; Mice ; Molecular Weight ; Thymoma - immunology</subject><ispartof>The Journal of immunology (1950), 1984-12, Vol.133 (6), p.3133-3137</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-1bb0d59dccc41ed83794dfe8425b3c9c12e5884056ba53b0cd9acfe9567459593</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8968258$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6333454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brooks, KH</creatorcontrib><creatorcontrib>Uhr, JW</creatorcontrib><creatorcontrib>Vitetta, ES</creatorcontrib><title>A B cell growth factor-like activity is secreted by cloned, neoplastic B cells</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>Supernatants from synchronized clones of neoplastic B cells (BCL1) were found to contain a B cell growth factor (BCGFI)-like activity. The BCGF activity in the BCL1 supernatants (SN) could synergize with EL-4 SN in the late phases of an IL 1-dependent BCGF I assay (days 5 through 8). These SN did not contain any detectable BCGF II, IL, 1, or IL 2 activity. In contrast to EL-4-derived BCGF I, which has a m.w. of approximately 18,000, the BCL1-BCGF activity has a m.w. of approximately 4500. Because the BCGF activity in BCL1 SN fluctuates with cell cycle in synchronized cultures, this BCL1-BCGF may play an auto-stimulatory role in B cell proliferation.</description><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>B-Lymphocytes - cytology</subject><subject>B-Lymphocytes - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell Cycle</subject><subject>Cell interactions</subject><subject>Cell Transformation, Neoplastic - immunology</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Clone Cells - metabolism</subject><subject>Drug Synergism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Growth Substances - isolation & purification</subject><subject>Growth Substances - metabolism</subject><subject>Growth Substances - physiology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Interleukin-1 - physiology</subject><subject>Interleukin-4</subject><subject>Kinetics</subject><subject>Lymphocyte Activation</subject><subject>Lymphokines - isolation & purification</subject><subject>Lymphokines - metabolism</subject><subject>Lymphokines - physiology</subject><subject>Mice</subject><subject>Molecular Weight</subject><subject>Thymoma - immunology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtOwzAQRS0EKqXwBQjJCwQbUuz4kXhZKl5SBRtYW47jtC5OU-yUqH-Pq4aK1Yw0Z-6MDgCXGI0pouJ-aet6s2rcGBMy5mMSyxEYYsZQwjnix2CIUJomOOPZKTgLYYkQ4iilAzDghBDK6BC8TeAD1MY5OPdN1y5gpXTb-MTZLwNja39su4U2wGC0N60pYbGF2jUrU97BlWnWToXW6j4knIOTSrlgLvo6Ap9Pjx_Tl2T2_vw6ncwSTUnWJrgoUMlEqbWm2JQ5yQQtK5PTlBVEC41Tw_KcIsYLxUiBdCmUroxgPKNMMEFG4Gafu_bN98aEVtY27D5Q8adNkJjijJGcRZDsQe2bELyp5NrbWvmtxEjuLMo_izLqk1zuLMatqz5-U9SmPOz02uL8up-roJWrvFppGw5YLniesjxit3tsYeeLznojQ62ci6FYdl337-AvL56JrQ</recordid><startdate>198412</startdate><enddate>198412</enddate><creator>Brooks, KH</creator><creator>Uhr, JW</creator><creator>Vitetta, ES</creator><general>Am Assoc Immnol</general><general>American Association of Immunologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>198412</creationdate><title>A B cell growth factor-like activity is secreted by cloned, neoplastic B cells</title><author>Brooks, KH ; Uhr, JW ; Vitetta, ES</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-1bb0d59dccc41ed83794dfe8425b3c9c12e5884056ba53b0cd9acfe9567459593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>B-Lymphocytes - cytology</topic><topic>B-Lymphocytes - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell Cycle</topic><topic>Cell interactions</topic><topic>Cell Transformation, Neoplastic - immunology</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Clone Cells - metabolism</topic><topic>Drug Synergism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Growth Substances - isolation & purification</topic><topic>Growth Substances - metabolism</topic><topic>Growth Substances - physiology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Interleukin-1 - physiology</topic><topic>Interleukin-4</topic><topic>Kinetics</topic><topic>Lymphocyte Activation</topic><topic>Lymphokines - isolation & purification</topic><topic>Lymphokines - metabolism</topic><topic>Lymphokines - physiology</topic><topic>Mice</topic><topic>Molecular Weight</topic><topic>Thymoma - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brooks, KH</creatorcontrib><creatorcontrib>Uhr, JW</creatorcontrib><creatorcontrib>Vitetta, ES</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brooks, KH</au><au>Uhr, JW</au><au>Vitetta, ES</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A B cell growth factor-like activity is secreted by cloned, neoplastic B cells</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1984-12</date><risdate>1984</risdate><volume>133</volume><issue>6</issue><spage>3133</spage><epage>3137</epage><pages>3133-3137</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><coden>JOIMA3</coden><abstract>Supernatants from synchronized clones of neoplastic B cells (BCL1) were found to contain a B cell growth factor (BCGFI)-like activity. The BCGF activity in the BCL1 supernatants (SN) could synergize with EL-4 SN in the late phases of an IL 1-dependent BCGF I assay (days 5 through 8). These SN did not contain any detectable BCGF II, IL, 1, or IL 2 activity. In contrast to EL-4-derived BCGF I, which has a m.w. of approximately 18,000, the BCL1-BCGF activity has a m.w. of approximately 4500. Because the BCGF activity in BCL1 SN fluctuates with cell cycle in synchronized cultures, this BCL1-BCGF may play an auto-stimulatory role in B cell proliferation.</abstract><cop>Bethesda, MD</cop><pub>Am Assoc Immnol</pub><pmid>6333454</pmid><doi>10.4049/jimmunol.133.6.3133</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of immunology (1950), 1984-12, Vol.133 (6), p.3133-3137 |
| issn | 0022-1767 1550-6606 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Analysis of the immune response. Humoral and cellular immunity Animals B-Lymphocytes - cytology B-Lymphocytes - metabolism Biological and medical sciences Cell Cycle Cell interactions Cell Transformation, Neoplastic - immunology Cell Transformation, Neoplastic - metabolism Clone Cells - metabolism Drug Synergism Fundamental and applied biological sciences. Psychology Fundamental immunology Growth Substances - isolation & purification Growth Substances - metabolism Growth Substances - physiology Humans Immunobiology Interleukin-1 - physiology Interleukin-4 Kinetics Lymphocyte Activation Lymphokines - isolation & purification Lymphokines - metabolism Lymphokines - physiology Mice Molecular Weight Thymoma - immunology |
| title | A B cell growth factor-like activity is secreted by cloned, neoplastic B cells |
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