Effects of thyroxine treatment during lactation on the testicular function of rats across different ages
Thyroid hormones are involved in the development of several tissues and organs and are essential for the normal growth and reproductive function. The aim of this study was to determine the effects of thyroid hormones on the development of testis and progression of spermatogenesis. Lactating mothers...
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| Veröffentlicht in: | Folia histochemica et cytobiologica 2013-01, Vol.51 (2), p.107-114 |
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| container_title | Folia histochemica et cytobiologica |
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| creator | Souhila, Dahmani-Said Zohra, Hamouli-Said Kamel, Assia Hadj-Bekkouche, Fatima |
| description | Thyroid hormones are involved in the development of several tissues and organs and are essential for the normal growth and reproductive function. The aim of this study was to determine the effects of thyroid hormones on the development of testis and progression of spermatogenesis. Lactating mothers were treated with oral thyroxine (T4; 20 μg/100 g) for 20 days after parturition. The pups were decapitated at the age of 20, 40 and 60 days post partum. Neonatal hyperthyroidism resulted in a decrease in body and testis mass, an increase of free thyroxine and a decrease of testosterone concentrations in plasma of treated rats. The treatment was associated with a significant decrease of the diameter of seminiferous tubules and a slowdown in spermatogenesis, following a delay in the maturation of germ cells. We conclude that thyroid hormones affect the progression of postnatal spermatogenesis. |
| doi_str_mv | 10.5603/FHC.2013.0017 |
| format | Article |
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The aim of this study was to determine the effects of thyroid hormones on the development of testis and progression of spermatogenesis. Lactating mothers were treated with oral thyroxine (T4; 20 μg/100 g) for 20 days after parturition. The pups were decapitated at the age of 20, 40 and 60 days post partum. Neonatal hyperthyroidism resulted in a decrease in body and testis mass, an increase of free thyroxine and a decrease of testosterone concentrations in plasma of treated rats. The treatment was associated with a significant decrease of the diameter of seminiferous tubules and a slowdown in spermatogenesis, following a delay in the maturation of germ cells. We conclude that thyroid hormones affect the progression of postnatal spermatogenesis.</description><identifier>ISSN: 0239-8508</identifier><identifier>EISSN: 1897-5631</identifier><identifier>DOI: 10.5603/FHC.2013.0017</identifier><identifier>PMID: 23907939</identifier><language>eng</language><publisher>Poland: Wydawnictwo Via Medica</publisher><subject>Age Factors ; Animals ; Female ; Germ cells ; Hormones ; Hyperthyroidism ; Hyperthyroidism - chemically induced ; Hyperthyroidism - pathology ; Lactation ; Male ; Neonates ; Organs ; Parturition ; Rats ; Rats, Wistar ; Spermatogenesis ; Spermatogenesis - drug effects ; Testes ; Testis - drug effects ; Testis - growth & development ; Testis - pathology ; Testosterone ; Thyroid ; Thyroid gland ; Thyroid hormones ; Thyroxine ; Thyroxine - pharmacology ; Tubules</subject><ispartof>Folia histochemica et cytobiologica, 2013-01, Vol.51 (2), p.107-114</ispartof><rights>Copyright Folia Histochemica et Cytobiologica 2013</rights><rights>2013. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). 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The aim of this study was to determine the effects of thyroid hormones on the development of testis and progression of spermatogenesis. Lactating mothers were treated with oral thyroxine (T4; 20 μg/100 g) for 20 days after parturition. The pups were decapitated at the age of 20, 40 and 60 days post partum. Neonatal hyperthyroidism resulted in a decrease in body and testis mass, an increase of free thyroxine and a decrease of testosterone concentrations in plasma of treated rats. The treatment was associated with a significant decrease of the diameter of seminiferous tubules and a slowdown in spermatogenesis, following a delay in the maturation of germ cells. We conclude that thyroid hormones affect the progression of postnatal spermatogenesis.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Female</subject><subject>Germ cells</subject><subject>Hormones</subject><subject>Hyperthyroidism</subject><subject>Hyperthyroidism - chemically induced</subject><subject>Hyperthyroidism - pathology</subject><subject>Lactation</subject><subject>Male</subject><subject>Neonates</subject><subject>Organs</subject><subject>Parturition</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Spermatogenesis</subject><subject>Spermatogenesis - drug effects</subject><subject>Testes</subject><subject>Testis - drug effects</subject><subject>Testis - growth & development</subject><subject>Testis - pathology</subject><subject>Testosterone</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid hormones</subject><subject>Thyroxine</subject><subject>Thyroxine - pharmacology</subject><subject>Tubules</subject><issn>0239-8508</issn><issn>1897-5631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kUFLwzAYhoMobk6PXiXgxUtnviRNmqOMzQkDL3oOWZpuHV07kxTcvzdz04MHIRBInu_l_XgQugUyzgVhj7P5ZEwJsDEhIM_QEAols1wwOEdDQpnKipwUA3QVwoaQNMHhEg3SO5GKqSFaT6vK2RhwV-G43vvus24djt6ZuHVtxGXv63aFG2OjiXXX4nTiOhEuxNr2jfG46lt7_KqwNynKWN-FgMs6RftDiFm5cI0uKtMEd3O6R-h9Nn2bzLPF6_PL5GmRWcZVzOxSppKl5dRJVShLwYiSSWolAwpLqaw1ILhVArikUpBlURbGKQeUcuMIG6GHY-7Odx99aqm3dbCuaUzruj5o4CBzlvOcJ_T-D7rpet-mdpoKRQsic_ovBZznIARlkKjsSH3v7l2ld77eGr_XQPRBlE6i9EGUPohK_N0ptV9uXflL_5hhX-sXjN0</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Souhila, Dahmani-Said</creator><creator>Zohra, Hamouli-Said</creator><creator>Kamel, Assia</creator><creator>Hadj-Bekkouche, Fatima</creator><general>Wydawnictwo Via Medica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>Effects of thyroxine treatment during lactation on the testicular function of rats across different ages</title><author>Souhila, Dahmani-Said ; Zohra, Hamouli-Said ; Kamel, Assia ; Hadj-Bekkouche, Fatima</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-cb7560dc42e7989c21a6d372c73121b79cca164c961472760b8d8ae9e1224ae03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Female</topic><topic>Germ cells</topic><topic>Hormones</topic><topic>Hyperthyroidism</topic><topic>Hyperthyroidism - chemically induced</topic><topic>Hyperthyroidism - pathology</topic><topic>Lactation</topic><topic>Male</topic><topic>Neonates</topic><topic>Organs</topic><topic>Parturition</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Spermatogenesis</topic><topic>Spermatogenesis - drug effects</topic><topic>Testes</topic><topic>Testis - drug effects</topic><topic>Testis - growth & development</topic><topic>Testis - pathology</topic><topic>Testosterone</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid hormones</topic><topic>Thyroxine</topic><topic>Thyroxine - pharmacology</topic><topic>Tubules</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Souhila, Dahmani-Said</creatorcontrib><creatorcontrib>Zohra, Hamouli-Said</creatorcontrib><creatorcontrib>Kamel, Assia</creatorcontrib><creatorcontrib>Hadj-Bekkouche, Fatima</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Folia histochemica et cytobiologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Souhila, Dahmani-Said</au><au>Zohra, Hamouli-Said</au><au>Kamel, Assia</au><au>Hadj-Bekkouche, Fatima</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of thyroxine treatment during lactation on the testicular function of rats across different ages</atitle><jtitle>Folia histochemica et cytobiologica</jtitle><addtitle>Folia Histochem Cytobiol</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>51</volume><issue>2</issue><spage>107</spage><epage>114</epage><pages>107-114</pages><issn>0239-8508</issn><eissn>1897-5631</eissn><abstract>Thyroid hormones are involved in the development of several tissues and organs and are essential for the normal growth and reproductive function. The aim of this study was to determine the effects of thyroid hormones on the development of testis and progression of spermatogenesis. Lactating mothers were treated with oral thyroxine (T4; 20 μg/100 g) for 20 days after parturition. The pups were decapitated at the age of 20, 40 and 60 days post partum. Neonatal hyperthyroidism resulted in a decrease in body and testis mass, an increase of free thyroxine and a decrease of testosterone concentrations in plasma of treated rats. The treatment was associated with a significant decrease of the diameter of seminiferous tubules and a slowdown in spermatogenesis, following a delay in the maturation of germ cells. We conclude that thyroid hormones affect the progression of postnatal spermatogenesis.</abstract><cop>Poland</cop><pub>Wydawnictwo Via Medica</pub><pmid>23907939</pmid><doi>10.5603/FHC.2013.0017</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Folia histochemica et cytobiologica, 2013-01, Vol.51 (2), p.107-114 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Age Factors Animals Female Germ cells Hormones Hyperthyroidism Hyperthyroidism - chemically induced Hyperthyroidism - pathology Lactation Male Neonates Organs Parturition Rats Rats, Wistar Spermatogenesis Spermatogenesis - drug effects Testes Testis - drug effects Testis - growth & development Testis - pathology Testosterone Thyroid Thyroid gland Thyroid hormones Thyroxine Thyroxine - pharmacology Tubules |
| title | Effects of thyroxine treatment during lactation on the testicular function of rats across different ages |
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