Computed tomography has low sensitivity for the diagnosis of early colon cancer
Aim The accuracy of computed tomography (CT) in detecting local invasion (T status) and nodal metastasis (N status) of colon cancer was determined. Method Data on the preoperative CT scan of 153 lesions from 152 patients with colon cancer were reviewed retrospectively. Evaluation included the T stag...
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| Veröffentlicht in: | Colorectal disease 2013-07, Vol.15 (7), p.807-811 |
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| creator | Lao, I-H. Chao, H. Wang, Y.-J. Mak, C.-W. Tzeng, W.-S. Wu, R.-H. Chang, S.-T. Fang, J.-L. |
| description | Aim
The accuracy of computed tomography (CT) in detecting local invasion (T status) and nodal metastasis (N status) of colon cancer was determined.
Method
Data on the preoperative CT scan of 153 lesions from 152 patients with colon cancer were reviewed retrospectively. Evaluation included the T stage and N stage of the TNM system. The results were compared with those obtained by histopathological examination of the resected tumour.
Results
Of the 153 tumours, 117 (76.5%) were correctly classified as Stage T1 and T2 (33 tumours) and Stage T3 and T4 (84 tumours) by CT. The sensitivity and specificity were 70.2% and 79.2%, respectively, and the positive and negative predictive values were 85.7% and 60.0%. When analysed according to the individual T stage (Tx/Tis, T1, 2, 3, 4) and N stage (N0, 1, 2), the kappa coefficient with linear weighting was 0.208 (fair agreement) for T stage and 0.154 (slight agreement) for N stage. The estimation of tumour size showed good agreement with histopathology (Spearman correlation coefficient 0.865).
Conclusion
CT scanning of colonic cancer showed 75% accuracy in identifying T1 and T2 cancers combined, but gave poor agreement between CT and histopathology for individual T stages. |
| doi_str_mv | 10.1111/codi.12140 |
| format | Article |
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The accuracy of computed tomography (CT) in detecting local invasion (T status) and nodal metastasis (N status) of colon cancer was determined.
Method
Data on the preoperative CT scan of 153 lesions from 152 patients with colon cancer were reviewed retrospectively. Evaluation included the T stage and N stage of the TNM system. The results were compared with those obtained by histopathological examination of the resected tumour.
Results
Of the 153 tumours, 117 (76.5%) were correctly classified as Stage T1 and T2 (33 tumours) and Stage T3 and T4 (84 tumours) by CT. The sensitivity and specificity were 70.2% and 79.2%, respectively, and the positive and negative predictive values were 85.7% and 60.0%. When analysed according to the individual T stage (Tx/Tis, T1, 2, 3, 4) and N stage (N0, 1, 2), the kappa coefficient with linear weighting was 0.208 (fair agreement) for T stage and 0.154 (slight agreement) for N stage. The estimation of tumour size showed good agreement with histopathology (Spearman correlation coefficient 0.865).
Conclusion
CT scanning of colonic cancer showed 75% accuracy in identifying T1 and T2 cancers combined, but gave poor agreement between CT and histopathology for individual T stages.</description><identifier>ISSN: 1462-8910</identifier><identifier>EISSN: 1463-1318</identifier><identifier>DOI: 10.1111/codi.12140</identifier><identifier>PMID: 23350992</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Aged ; Carcinoma - diagnosis ; Carcinoma - diagnostic imaging ; Carcinoma - pathology ; Cohort Studies ; Colonic Neoplasms - diagnosis ; Colonic Neoplasms - diagnostic imaging ; Colonic Neoplasms - pathology ; Colonic Polyps - diagnosis ; Colonic Polyps - diagnostic imaging ; Colonic Polyps - pathology ; colonic polyps/radiology ; Early Detection of Cancer - methods ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging - methods ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed</subject><ispartof>Colorectal disease, 2013-07, Vol.15 (7), p.807-811</ispartof><rights>Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland</rights><rights>Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3670-9a70b08e3660dff646c49c882f2c5c41f098760818bd5caf295010b3a7380cda3</citedby><cites>FETCH-LOGICAL-c3670-9a70b08e3660dff646c49c882f2c5c41f098760818bd5caf295010b3a7380cda3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcodi.12140$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcodi.12140$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23350992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lao, I-H.</creatorcontrib><creatorcontrib>Chao, H.</creatorcontrib><creatorcontrib>Wang, Y.-J.</creatorcontrib><creatorcontrib>Mak, C.-W.</creatorcontrib><creatorcontrib>Tzeng, W.-S.</creatorcontrib><creatorcontrib>Wu, R.-H.</creatorcontrib><creatorcontrib>Chang, S.-T.</creatorcontrib><creatorcontrib>Fang, J.-L.</creatorcontrib><title>Computed tomography has low sensitivity for the diagnosis of early colon cancer</title><title>Colorectal disease</title><addtitle>Colorectal Dis</addtitle><description>Aim
The accuracy of computed tomography (CT) in detecting local invasion (T status) and nodal metastasis (N status) of colon cancer was determined.
Method
Data on the preoperative CT scan of 153 lesions from 152 patients with colon cancer were reviewed retrospectively. Evaluation included the T stage and N stage of the TNM system. The results were compared with those obtained by histopathological examination of the resected tumour.
Results
Of the 153 tumours, 117 (76.5%) were correctly classified as Stage T1 and T2 (33 tumours) and Stage T3 and T4 (84 tumours) by CT. The sensitivity and specificity were 70.2% and 79.2%, respectively, and the positive and negative predictive values were 85.7% and 60.0%. When analysed according to the individual T stage (Tx/Tis, T1, 2, 3, 4) and N stage (N0, 1, 2), the kappa coefficient with linear weighting was 0.208 (fair agreement) for T stage and 0.154 (slight agreement) for N stage. The estimation of tumour size showed good agreement with histopathology (Spearman correlation coefficient 0.865).
Conclusion
CT scanning of colonic cancer showed 75% accuracy in identifying T1 and T2 cancers combined, but gave poor agreement between CT and histopathology for individual T stages.</description><subject>Aged</subject><subject>Carcinoma - diagnosis</subject><subject>Carcinoma - diagnostic imaging</subject><subject>Carcinoma - pathology</subject><subject>Cohort Studies</subject><subject>Colonic Neoplasms - diagnosis</subject><subject>Colonic Neoplasms - diagnostic imaging</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colonic Polyps - diagnosis</subject><subject>Colonic Polyps - diagnostic imaging</subject><subject>Colonic Polyps - pathology</subject><subject>colonic polyps/radiology</subject><subject>Early Detection of Cancer - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging - methods</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Tomography, X-Ray Computed</subject><issn>1462-8910</issn><issn>1463-1318</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQQC0E4nvhByCPCCnFFye2M0KAgoToUFBHy3Xs1pDExU4p-fcUCozccje8e8ND6ATIANZzoX3lBpBCRrbQPmSMJkBBbH_faSIKIHvoIMYXQoBxELtoL6U0J0WR7qNR6ZvFsjMV7nzjZ0Et5j2eq4hrv8LRtNF17t11PbY-4G5ucOXUrPXRRewtNirUPda-9i3WqtUmHKEdq-pojn_2IXq-vXkq75KH0fC-vHxINGWcJIXiZEqEoYyRylqWMZ0VWojUpjrXGVhSCM6IADGtcq1sWuQEyJQqTgXRlaKH6GzjXQT_tjSxk42L2tS1ao1fRgkZ8JzmlPI1er5BdfAxBmPlIrhGhV4CkV8B5VdA-R1wDZ_-eJfTxlR_6G-xNQAbYOVq0_-jkuXo-v5Xmmx-XOzMx9-PCq-SccpzOXkcyglj46fxuJRX9BODiYn1</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Lao, I-H.</creator><creator>Chao, H.</creator><creator>Wang, Y.-J.</creator><creator>Mak, C.-W.</creator><creator>Tzeng, W.-S.</creator><creator>Wu, R.-H.</creator><creator>Chang, S.-T.</creator><creator>Fang, J.-L.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201307</creationdate><title>Computed tomography has low sensitivity for the diagnosis of early colon cancer</title><author>Lao, I-H. ; Chao, H. ; Wang, Y.-J. ; Mak, C.-W. ; Tzeng, W.-S. ; Wu, R.-H. ; Chang, S.-T. ; Fang, J.-L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3670-9a70b08e3660dff646c49c882f2c5c41f098760818bd5caf295010b3a7380cda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Carcinoma - diagnosis</topic><topic>Carcinoma - diagnostic imaging</topic><topic>Carcinoma - pathology</topic><topic>Cohort Studies</topic><topic>Colonic Neoplasms - diagnosis</topic><topic>Colonic Neoplasms - diagnostic imaging</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colonic Polyps - diagnosis</topic><topic>Colonic Polyps - diagnostic imaging</topic><topic>Colonic Polyps - pathology</topic><topic>colonic polyps/radiology</topic><topic>Early Detection of Cancer - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging - methods</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lao, I-H.</creatorcontrib><creatorcontrib>Chao, H.</creatorcontrib><creatorcontrib>Wang, Y.-J.</creatorcontrib><creatorcontrib>Mak, C.-W.</creatorcontrib><creatorcontrib>Tzeng, W.-S.</creatorcontrib><creatorcontrib>Wu, R.-H.</creatorcontrib><creatorcontrib>Chang, S.-T.</creatorcontrib><creatorcontrib>Fang, J.-L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lao, I-H.</au><au>Chao, H.</au><au>Wang, Y.-J.</au><au>Mak, C.-W.</au><au>Tzeng, W.-S.</au><au>Wu, R.-H.</au><au>Chang, S.-T.</au><au>Fang, J.-L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Computed tomography has low sensitivity for the diagnosis of early colon cancer</atitle><jtitle>Colorectal disease</jtitle><addtitle>Colorectal Dis</addtitle><date>2013-07</date><risdate>2013</risdate><volume>15</volume><issue>7</issue><spage>807</spage><epage>811</epage><pages>807-811</pages><issn>1462-8910</issn><eissn>1463-1318</eissn><abstract>Aim
The accuracy of computed tomography (CT) in detecting local invasion (T status) and nodal metastasis (N status) of colon cancer was determined.
Method
Data on the preoperative CT scan of 153 lesions from 152 patients with colon cancer were reviewed retrospectively. Evaluation included the T stage and N stage of the TNM system. The results were compared with those obtained by histopathological examination of the resected tumour.
Results
Of the 153 tumours, 117 (76.5%) were correctly classified as Stage T1 and T2 (33 tumours) and Stage T3 and T4 (84 tumours) by CT. The sensitivity and specificity were 70.2% and 79.2%, respectively, and the positive and negative predictive values were 85.7% and 60.0%. When analysed according to the individual T stage (Tx/Tis, T1, 2, 3, 4) and N stage (N0, 1, 2), the kappa coefficient with linear weighting was 0.208 (fair agreement) for T stage and 0.154 (slight agreement) for N stage. The estimation of tumour size showed good agreement with histopathology (Spearman correlation coefficient 0.865).
Conclusion
CT scanning of colonic cancer showed 75% accuracy in identifying T1 and T2 cancers combined, but gave poor agreement between CT and histopathology for individual T stages.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23350992</pmid><doi>10.1111/codi.12140</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Carcinoma - diagnosis Carcinoma - diagnostic imaging Carcinoma - pathology Cohort Studies Colonic Neoplasms - diagnosis Colonic Neoplasms - diagnostic imaging Colonic Neoplasms - pathology Colonic Polyps - diagnosis Colonic Polyps - diagnostic imaging Colonic Polyps - pathology colonic polyps/radiology Early Detection of Cancer - methods Female Humans Male Middle Aged Neoplasm Staging - methods Retrospective Studies Sensitivity and Specificity Tomography, X-Ray Computed |
| title | Computed tomography has low sensitivity for the diagnosis of early colon cancer |
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