The Presence of Outer Arm Fucose Residues on the N‑Glycans of Tissue Inhibitor of Metalloproteinases‑1 Reduces Its Activity

Tissue inhibitor of metalloproteinases-1 (TIMP-1) inhibits matrix metalloproteinases (MMPs) by binding at a 1:1 stoichiometry. Here we have shown the involvement of N-glycosylation in the MMP inhibitory ability of TIMP-1. TIMP-1, purified from HEK 293 cells overexpressing TIMP-1 (293 TIMP-1), showed...

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Veröffentlicht in:	Journal of proteome research 2013-08, Vol.12 (8), p.3547-3560
Hauptverfasser:	Kim, Han Ie, Saldova, Radka, Park, Jun Hyoung, Lee, Young Hun, Harvey, David J, Wormald, Mark R, Wynne, Kieran, Elia, Giuliano, Kim, Hwa-Jung, Rudd, Pauline M, Lee, Seung-Taek
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Baculoviridae - genetics Binding Sites Carbohydrate Sequence Fibroblasts - cytology Fibroblasts - metabolism Fucose - chemistry Fucose - metabolism Fucosyltransferases - deficiency Fucosyltransferases - genetics Gene Expression Regulation HEK293 Cells Humans Lewis X Antigen - genetics Matrix Metalloproteinase 1 - chemistry Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Models, Molecular Molecular Sequence Data Polysaccharides - chemistry Polysaccharides - metabolism Protein Binding Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sf9 Cells Signal Transduction Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spodoptera Tissue Inhibitor of Metalloproteinase-1 - chemistry Tissue Inhibitor of Metalloproteinase-1 - genetics Tissue Inhibitor of Metalloproteinase-1 - metabolism
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