Understanding the brown adipocyte as a contributor to energy homeostasis
Highlights • Brown adipocytes express UCP1, which is capable of uncoupling fatty acid oxidation from ATP synthesis, leading to heat production upon stimulation. • The presence of active brown adipocytes has been demonstrated in adult humans. • Outdoor temperatures, age, and body fat mass affect the...
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| Veröffentlicht in: | Trends in endocrinology and metabolism 2013-08, Vol.24 (8), p.408-420 |
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| creator | Chechi, Kanta Carpentier, Andre C Richard, Denis |
| description | Highlights • Brown adipocytes express UCP1, which is capable of uncoupling fatty acid oxidation from ATP synthesis, leading to heat production upon stimulation. • The presence of active brown adipocytes has been demonstrated in adult humans. • Outdoor temperatures, age, and body fat mass affect the detection and activity of brown adipocytes in humans. • Metabolic activity of brown adipocytes has been shown to increase energy expenditure in humans. • Environmental, biological, or pharmacological means capable of stimulating brown adipose tissue selectively may serve to counteract obesity and diabetes. |
| doi_str_mv | 10.1016/j.tem.2013.04.002 |
| format | Article |
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| ispartof | Trends in endocrinology and metabolism, 2013-08, Vol.24 (8), p.408-420 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adipocytes, Brown - metabolism brain melanocortin system brown adipose tissue Endocrinology & Metabolism energy balance Energy Metabolism - physiology Humans Ion Channels - metabolism Mitochondrial Proteins - metabolism sympathetic nervous system Sympathetic Nervous System - metabolism thermogenesis Thermogenesis - physiology thermoregulation Uncoupling Protein 1 white adipose tissue |
| title | Understanding the brown adipocyte as a contributor to energy homeostasis |
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