Novel taste-masked orally disintegrating tablets for a highly soluble drug with an extremely bitter taste: design rationale and evaluation

The purpose of this study was to evaluate the taste masking potential of novel solid dispersions (SDs) using Eudragit® EPO as the excipient when incorporated into the orally disintegrating tablets (ODTs) for delivering a highly soluble drug with an extremely bitter taste. The pyridostigmine bromides...

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Veröffentlicht in:	Drug development and industrial pharmacy 2013-09, Vol.39 (9), p.1364-1371
Hauptverfasser:	Tan, Qunyou, Zhang, Li, Liu, Guodong, He, Dan, Yin, Huafeng, Wang, Hong, Wu, Jianyong, Liao, Hong, Zhang, Jingqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bioequivalence Cellulose - chemistry central composite design Chemical Phenomena Chemistry, Pharmaceutical - methods Cholinesterase Inhibitors - adverse effects Cholinesterase Inhibitors - analysis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacokinetics Excipients - chemistry Female Flavoring Agents - chemistry Flavoring Agents - metabolism Humans Kinetics Male Models, Chemical orally disintegrating tablets Polymethacrylic Acids - chemistry Povidone - chemistry Pyridostigmine bromide Pyridostigmine Bromide - adverse effects Pyridostigmine Bromide - analysis Pyridostigmine Bromide - chemistry Pyridostigmine Bromide - pharmacokinetics Rabbits Random Allocation Saliva - chemistry Solid dispersions Solubility Tablets Taste taste-masked Therapeutic Equivalency
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