Lobular Neoplasia of the Breast Revisited With Emphasis on the Role of E-Cadherin Immunohistochemistry
Lobular neoplasia (LN) is a term that encompasses both lobular carcinoma in situ and atypical lobular hyperplasia. These lesions have been shown to constitute both risk indicators and nonobligate precursors of invasive breast cancer, they are relatively uncommon, and are most often identified in spe...
Gespeichert in:
| Veröffentlicht in: | The American journal of surgical pathology 2013-07, Vol.37 (7), p.e1-e11 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e11 |
|---|---|
| container_issue | 7 |
| container_start_page | e1 |
| container_title | The American journal of surgical pathology |
| container_volume | 37 |
| creator | Dabbs, David J Schnitt, Stuart J Geyer, Felipe C Weigelt, Britta Baehner, Frederick L Decker, Thomas Eusebi, Vincenzo Fox, Stephen B Ichihara, Shu Lakhani, Sunil R Palacios, Jose Rakha, Emad Richardson, Andrea L Schmitt, Fernando C Tan, Puay-Hoon Tse, Gary M Vincent-Salomon, Anne Ellis, Ian O Badve, Sunil Reis-Filho, Jorge S |
| description | Lobular neoplasia (LN) is a term that encompasses both lobular carcinoma in situ and atypical lobular hyperplasia. These lesions have been shown to constitute both risk indicators and nonobligate precursors of invasive breast cancer, they are relatively uncommon, and are most often identified in specimens taken for other reasons. Their incidence has increased in the last 2 decades, and novel variants, including a pleomorphic type, have been described. Loss of E-cadherin expression is recognized as a hallmark diagnostic feature of LN and invasive lobular carcinomas, and immunohistochemical (IHC) analysis using anti-E-cadherin antibodies has been proven to be a useful method to differentiate between lobular and ductal lesions. The frequent use of E-cadherin IHC analysis in routine diagnostic histopathology, however, has resulted in confusion with regard to the actual value of IHC with antibodies against E-cadherin and other proteins of the cadherin-catenin complex. This review provides an update on recent clinicopathologic and molecular data on LN and invasive lobular carcinoma and a discussion about the use and limitations of IHC with E-cadherin in diagnostic breast pathology. |
| doi_str_mv | 10.1097/PAS.0b013e3182918a2b |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1417528742</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1417528742</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3521-e3d5975a7589edc9d8b39f9a3850ec955e3ec7a623d63d6d79eadedfee22aa323</originalsourceid><addsrcrecordid>eNpdUG1LHDEQDlLxTtt_ICUf-2Wvedlcko96XFU4qqilH0N2M8uuZi9nslvx35utVwsOA8PMPC_wIHRKyYISLb_fnN0tSEUoB04V01RZVh2gORWcFfmvP6E5oaUsBFViho5TeiCEMkXZEZoxLoXWXM5RswnV6G3EPyHsvE2dxaHBQwv4PIJNA76FP13qBnD4dze0eN3v2oxKOGz_om6Dh4mxLlbWtRC7Lb7q-3Eb2i4NoW6hzzO-fEaHjfUJvuznCfr1Y32_uiw21xdXq7NNUXPBaAHcCS2FlUJpcLV2quK60ZYrQaDWQgCHWtol426Z20kN1oFrABizljN-gr696e5ieBohDSb71-C93UIYk6EllYIpWU7Q8g1ax5BShMbsYtfb-GIoMVPCJidsPiacaV_3DmPVg3sn_Yv0v-5z8APE9OjHZ4imBeuH1pCpSqkKlnWJzEsxXSh_BTvOiNE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1417528742</pqid></control><display><type>article</type><title>Lobular Neoplasia of the Breast Revisited With Emphasis on the Role of E-Cadherin Immunohistochemistry</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Dabbs, David J ; Schnitt, Stuart J ; Geyer, Felipe C ; Weigelt, Britta ; Baehner, Frederick L ; Decker, Thomas ; Eusebi, Vincenzo ; Fox, Stephen B ; Ichihara, Shu ; Lakhani, Sunil R ; Palacios, Jose ; Rakha, Emad ; Richardson, Andrea L ; Schmitt, Fernando C ; Tan, Puay-Hoon ; Tse, Gary M ; Vincent-Salomon, Anne ; Ellis, Ian O ; Badve, Sunil ; Reis-Filho, Jorge S</creator><creatorcontrib>Dabbs, David J ; Schnitt, Stuart J ; Geyer, Felipe C ; Weigelt, Britta ; Baehner, Frederick L ; Decker, Thomas ; Eusebi, Vincenzo ; Fox, Stephen B ; Ichihara, Shu ; Lakhani, Sunil R ; Palacios, Jose ; Rakha, Emad ; Richardson, Andrea L ; Schmitt, Fernando C ; Tan, Puay-Hoon ; Tse, Gary M ; Vincent-Salomon, Anne ; Ellis, Ian O ; Badve, Sunil ; Reis-Filho, Jorge S</creatorcontrib><description>Lobular neoplasia (LN) is a term that encompasses both lobular carcinoma in situ and atypical lobular hyperplasia. These lesions have been shown to constitute both risk indicators and nonobligate precursors of invasive breast cancer, they are relatively uncommon, and are most often identified in specimens taken for other reasons. Their incidence has increased in the last 2 decades, and novel variants, including a pleomorphic type, have been described. Loss of E-cadherin expression is recognized as a hallmark diagnostic feature of LN and invasive lobular carcinomas, and immunohistochemical (IHC) analysis using anti-E-cadherin antibodies has been proven to be a useful method to differentiate between lobular and ductal lesions. The frequent use of E-cadherin IHC analysis in routine diagnostic histopathology, however, has resulted in confusion with regard to the actual value of IHC with antibodies against E-cadherin and other proteins of the cadherin-catenin complex. This review provides an update on recent clinicopathologic and molecular data on LN and invasive lobular carcinoma and a discussion about the use and limitations of IHC with E-cadherin in diagnostic breast pathology.</description><identifier>ISSN: 0147-5185</identifier><identifier>EISSN: 1532-0979</identifier><identifier>DOI: 10.1097/PAS.0b013e3182918a2b</identifier><identifier>PMID: 23759937</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, Inc</publisher><subject>Biomarkers, Tumor - metabolism ; Breast Neoplasms - diagnosis ; Breast Neoplasms - genetics ; Breast Neoplasms - metabolism ; Cadherins - genetics ; Cadherins - metabolism ; Carcinoma in Situ - diagnosis ; Carcinoma in Situ - genetics ; Carcinoma in Situ - metabolism ; Carcinoma, Ductal, Breast - diagnosis ; Carcinoma, Ductal, Breast - genetics ; Carcinoma, Ductal, Breast - metabolism ; Carcinoma, Lobular - diagnosis ; Carcinoma, Lobular - genetics ; Carcinoma, Lobular - metabolism ; Catenins - genetics ; Catenins - metabolism ; Diagnosis, Differential ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry - methods ; Molecular Diagnostic Techniques</subject><ispartof>The American journal of surgical pathology, 2013-07, Vol.37 (7), p.e1-e11</ispartof><rights>2013 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3521-e3d5975a7589edc9d8b39f9a3850ec955e3ec7a623d63d6d79eadedfee22aa323</citedby><cites>FETCH-LOGICAL-c3521-e3d5975a7589edc9d8b39f9a3850ec955e3ec7a623d63d6d79eadedfee22aa323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23759937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dabbs, David J</creatorcontrib><creatorcontrib>Schnitt, Stuart J</creatorcontrib><creatorcontrib>Geyer, Felipe C</creatorcontrib><creatorcontrib>Weigelt, Britta</creatorcontrib><creatorcontrib>Baehner, Frederick L</creatorcontrib><creatorcontrib>Decker, Thomas</creatorcontrib><creatorcontrib>Eusebi, Vincenzo</creatorcontrib><creatorcontrib>Fox, Stephen B</creatorcontrib><creatorcontrib>Ichihara, Shu</creatorcontrib><creatorcontrib>Lakhani, Sunil R</creatorcontrib><creatorcontrib>Palacios, Jose</creatorcontrib><creatorcontrib>Rakha, Emad</creatorcontrib><creatorcontrib>Richardson, Andrea L</creatorcontrib><creatorcontrib>Schmitt, Fernando C</creatorcontrib><creatorcontrib>Tan, Puay-Hoon</creatorcontrib><creatorcontrib>Tse, Gary M</creatorcontrib><creatorcontrib>Vincent-Salomon, Anne</creatorcontrib><creatorcontrib>Ellis, Ian O</creatorcontrib><creatorcontrib>Badve, Sunil</creatorcontrib><creatorcontrib>Reis-Filho, Jorge S</creatorcontrib><title>Lobular Neoplasia of the Breast Revisited With Emphasis on the Role of E-Cadherin Immunohistochemistry</title><title>The American journal of surgical pathology</title><addtitle>Am J Surg Pathol</addtitle><description>Lobular neoplasia (LN) is a term that encompasses both lobular carcinoma in situ and atypical lobular hyperplasia. These lesions have been shown to constitute both risk indicators and nonobligate precursors of invasive breast cancer, they are relatively uncommon, and are most often identified in specimens taken for other reasons. Their incidence has increased in the last 2 decades, and novel variants, including a pleomorphic type, have been described. Loss of E-cadherin expression is recognized as a hallmark diagnostic feature of LN and invasive lobular carcinomas, and immunohistochemical (IHC) analysis using anti-E-cadherin antibodies has been proven to be a useful method to differentiate between lobular and ductal lesions. The frequent use of E-cadherin IHC analysis in routine diagnostic histopathology, however, has resulted in confusion with regard to the actual value of IHC with antibodies against E-cadherin and other proteins of the cadherin-catenin complex. This review provides an update on recent clinicopathologic and molecular data on LN and invasive lobular carcinoma and a discussion about the use and limitations of IHC with E-cadherin in diagnostic breast pathology.</description><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - metabolism</subject><subject>Cadherins - genetics</subject><subject>Cadherins - metabolism</subject><subject>Carcinoma in Situ - diagnosis</subject><subject>Carcinoma in Situ - genetics</subject><subject>Carcinoma in Situ - metabolism</subject><subject>Carcinoma, Ductal, Breast - diagnosis</subject><subject>Carcinoma, Ductal, Breast - genetics</subject><subject>Carcinoma, Ductal, Breast - metabolism</subject><subject>Carcinoma, Lobular - diagnosis</subject><subject>Carcinoma, Lobular - genetics</subject><subject>Carcinoma, Lobular - metabolism</subject><subject>Catenins - genetics</subject><subject>Catenins - metabolism</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Molecular Diagnostic Techniques</subject><issn>0147-5185</issn><issn>1532-0979</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUG1LHDEQDlLxTtt_ICUf-2Wvedlcko96XFU4qqilH0N2M8uuZi9nslvx35utVwsOA8PMPC_wIHRKyYISLb_fnN0tSEUoB04V01RZVh2gORWcFfmvP6E5oaUsBFViho5TeiCEMkXZEZoxLoXWXM5RswnV6G3EPyHsvE2dxaHBQwv4PIJNA76FP13qBnD4dze0eN3v2oxKOGz_om6Dh4mxLlbWtRC7Lb7q-3Eb2i4NoW6hzzO-fEaHjfUJvuznCfr1Y32_uiw21xdXq7NNUXPBaAHcCS2FlUJpcLV2quK60ZYrQaDWQgCHWtol426Z20kN1oFrABizljN-gr696e5ieBohDSb71-C93UIYk6EllYIpWU7Q8g1ax5BShMbsYtfb-GIoMVPCJidsPiacaV_3DmPVg3sn_Yv0v-5z8APE9OjHZ4imBeuH1pCpSqkKlnWJzEsxXSh_BTvOiNE</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Dabbs, David J</creator><creator>Schnitt, Stuart J</creator><creator>Geyer, Felipe C</creator><creator>Weigelt, Britta</creator><creator>Baehner, Frederick L</creator><creator>Decker, Thomas</creator><creator>Eusebi, Vincenzo</creator><creator>Fox, Stephen B</creator><creator>Ichihara, Shu</creator><creator>Lakhani, Sunil R</creator><creator>Palacios, Jose</creator><creator>Rakha, Emad</creator><creator>Richardson, Andrea L</creator><creator>Schmitt, Fernando C</creator><creator>Tan, Puay-Hoon</creator><creator>Tse, Gary M</creator><creator>Vincent-Salomon, Anne</creator><creator>Ellis, Ian O</creator><creator>Badve, Sunil</creator><creator>Reis-Filho, Jorge S</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201307</creationdate><title>Lobular Neoplasia of the Breast Revisited With Emphasis on the Role of E-Cadherin Immunohistochemistry</title><author>Dabbs, David J ; Schnitt, Stuart J ; Geyer, Felipe C ; Weigelt, Britta ; Baehner, Frederick L ; Decker, Thomas ; Eusebi, Vincenzo ; Fox, Stephen B ; Ichihara, Shu ; Lakhani, Sunil R ; Palacios, Jose ; Rakha, Emad ; Richardson, Andrea L ; Schmitt, Fernando C ; Tan, Puay-Hoon ; Tse, Gary M ; Vincent-Salomon, Anne ; Ellis, Ian O ; Badve, Sunil ; Reis-Filho, Jorge S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3521-e3d5975a7589edc9d8b39f9a3850ec955e3ec7a623d63d6d79eadedfee22aa323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - metabolism</topic><topic>Cadherins - genetics</topic><topic>Cadherins - metabolism</topic><topic>Carcinoma in Situ - diagnosis</topic><topic>Carcinoma in Situ - genetics</topic><topic>Carcinoma in Situ - metabolism</topic><topic>Carcinoma, Ductal, Breast - diagnosis</topic><topic>Carcinoma, Ductal, Breast - genetics</topic><topic>Carcinoma, Ductal, Breast - metabolism</topic><topic>Carcinoma, Lobular - diagnosis</topic><topic>Carcinoma, Lobular - genetics</topic><topic>Carcinoma, Lobular - metabolism</topic><topic>Catenins - genetics</topic><topic>Catenins - metabolism</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>Molecular Diagnostic Techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dabbs, David J</creatorcontrib><creatorcontrib>Schnitt, Stuart J</creatorcontrib><creatorcontrib>Geyer, Felipe C</creatorcontrib><creatorcontrib>Weigelt, Britta</creatorcontrib><creatorcontrib>Baehner, Frederick L</creatorcontrib><creatorcontrib>Decker, Thomas</creatorcontrib><creatorcontrib>Eusebi, Vincenzo</creatorcontrib><creatorcontrib>Fox, Stephen B</creatorcontrib><creatorcontrib>Ichihara, Shu</creatorcontrib><creatorcontrib>Lakhani, Sunil R</creatorcontrib><creatorcontrib>Palacios, Jose</creatorcontrib><creatorcontrib>Rakha, Emad</creatorcontrib><creatorcontrib>Richardson, Andrea L</creatorcontrib><creatorcontrib>Schmitt, Fernando C</creatorcontrib><creatorcontrib>Tan, Puay-Hoon</creatorcontrib><creatorcontrib>Tse, Gary M</creatorcontrib><creatorcontrib>Vincent-Salomon, Anne</creatorcontrib><creatorcontrib>Ellis, Ian O</creatorcontrib><creatorcontrib>Badve, Sunil</creatorcontrib><creatorcontrib>Reis-Filho, Jorge S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dabbs, David J</au><au>Schnitt, Stuart J</au><au>Geyer, Felipe C</au><au>Weigelt, Britta</au><au>Baehner, Frederick L</au><au>Decker, Thomas</au><au>Eusebi, Vincenzo</au><au>Fox, Stephen B</au><au>Ichihara, Shu</au><au>Lakhani, Sunil R</au><au>Palacios, Jose</au><au>Rakha, Emad</au><au>Richardson, Andrea L</au><au>Schmitt, Fernando C</au><au>Tan, Puay-Hoon</au><au>Tse, Gary M</au><au>Vincent-Salomon, Anne</au><au>Ellis, Ian O</au><au>Badve, Sunil</au><au>Reis-Filho, Jorge S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lobular Neoplasia of the Breast Revisited With Emphasis on the Role of E-Cadherin Immunohistochemistry</atitle><jtitle>The American journal of surgical pathology</jtitle><addtitle>Am J Surg Pathol</addtitle><date>2013-07</date><risdate>2013</risdate><volume>37</volume><issue>7</issue><spage>e1</spage><epage>e11</epage><pages>e1-e11</pages><issn>0147-5185</issn><eissn>1532-0979</eissn><abstract>Lobular neoplasia (LN) is a term that encompasses both lobular carcinoma in situ and atypical lobular hyperplasia. These lesions have been shown to constitute both risk indicators and nonobligate precursors of invasive breast cancer, they are relatively uncommon, and are most often identified in specimens taken for other reasons. Their incidence has increased in the last 2 decades, and novel variants, including a pleomorphic type, have been described. Loss of E-cadherin expression is recognized as a hallmark diagnostic feature of LN and invasive lobular carcinomas, and immunohistochemical (IHC) analysis using anti-E-cadherin antibodies has been proven to be a useful method to differentiate between lobular and ductal lesions. The frequent use of E-cadherin IHC analysis in routine diagnostic histopathology, however, has resulted in confusion with regard to the actual value of IHC with antibodies against E-cadherin and other proteins of the cadherin-catenin complex. This review provides an update on recent clinicopathologic and molecular data on LN and invasive lobular carcinoma and a discussion about the use and limitations of IHC with E-cadherin in diagnostic breast pathology.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>23759937</pmid><doi>10.1097/PAS.0b013e3182918a2b</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0147-5185 |
| ispartof | The American journal of surgical pathology, 2013-07, Vol.37 (7), p.e1-e11 |
| issn | 0147-5185 1532-0979 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1417528742 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Biomarkers, Tumor - metabolism Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - metabolism Cadherins - genetics Cadherins - metabolism Carcinoma in Situ - diagnosis Carcinoma in Situ - genetics Carcinoma in Situ - metabolism Carcinoma, Ductal, Breast - diagnosis Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - metabolism Carcinoma, Lobular - diagnosis Carcinoma, Lobular - genetics Carcinoma, Lobular - metabolism Catenins - genetics Catenins - metabolism Diagnosis, Differential Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry - methods Molecular Diagnostic Techniques |
| title | Lobular Neoplasia of the Breast Revisited With Emphasis on the Role of E-Cadherin Immunohistochemistry |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T01%3A03%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lobular%20Neoplasia%20of%20the%20Breast%20Revisited%20With%20Emphasis%20on%20the%20Role%20of%20E-Cadherin%20Immunohistochemistry&rft.jtitle=The%20American%20journal%20of%20surgical%20pathology&rft.au=Dabbs,%20David%20J&rft.date=2013-07&rft.volume=37&rft.issue=7&rft.spage=e1&rft.epage=e11&rft.pages=e1-e11&rft.issn=0147-5185&rft.eissn=1532-0979&rft_id=info:doi/10.1097/PAS.0b013e3182918a2b&rft_dat=%3Cproquest_cross%3E1417528742%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1417528742&rft_id=info:pmid/23759937&rfr_iscdi=true |