Isolation of activated ras transforming genes from two patients with Hodgkin's disease

Despite impressive advances in the clinical management of Hodgkin's disease, litle is known about its cellular origin or the mechanism(s) of “Hodgkinogenesis.” Recent findings that certain human cellular oncogenes can cause malignant transformation suggest that aberrant activation of these gene...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 1985, Vol.11 (1), p.49-55
Hauptverfasser:	Sklar, Marshall D., Kitchingman, Geoffrey R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Animals Base Sequence Biological and medical sciences Cell Line Cell Transformation, Neoplastic DNA Restriction Enzymes DNA, Neoplasm - genetics Electrophoresis, Agar Gel Female Fibroblasts - pathology Hematologic and hematopoietic diseases Hodgkin Disease - genetics Hodgkin Disease - pathology Hodgkin's disease Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Macrophage Macrophages - pathology Male Medical sciences Mice Mice, Inbred BALB C N- ras Nucleic Acid Hybridization Oncogene Oncogenes Transfection
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