Antiplatelet therapy after Genous EPC-capturing coroNary stenT implantatiOn The ARGENTO Study: a prospective, multicenter registry
To investigate the safety and efficacy of Genous Bio-engineered R stent (GRS) with ≤ 15-day or >15-day dual antiplatelet therapy (DAT), in patients undergoing percutaneous coronary intervention (PCI), with known or expected low compliance to long-term DAT (Antiplatelet theRapy after Genous EPC-ca...
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| Veröffentlicht in: | International journal of cardiology 2013-08, Vol.167 (3), p.757-761 |
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| container_title | International journal of cardiology |
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| creator | CASSESE, Salvatore GALASSO, Gennaro PISCIONE, Federico SCIAHBASI, Alessandro SCACCIATELLA, Paolo MUCAJ, Andi PICCOLO, Raffaele D'ANNA, Carolina PANGRAZI, Alberta LIOY, Ernesto MARRA, Sebastiano |
| description | To investigate the safety and efficacy of Genous Bio-engineered R stent (GRS) with ≤ 15-day or >15-day dual antiplatelet therapy (DAT), in patients undergoing percutaneous coronary intervention (PCI), with known or expected low compliance to long-term DAT (Antiplatelet theRapy after Genous EPC-capturing coroNary stenT implantatiOn--ARGENTO study).
Consecutive patients without ≤ 12-month revascularization history, known statins allergy, known hypersensitivity reaction or previous or concomitant monoclonal and/or recombinant antibodies therapy, treated with single- or multivessel PCI plus GRS, were prospectively enrolled, at four PCI centers. Major adverse cardiac events (MACEs), the composite of cardiac death, any myocardial infarction (MI) and target vessel revascularization (TVR), and stent thrombosis (ST) cumulative incidences were evaluated.
Between March 2008 and March 2010, 384 patients (70.3% male, 423 lesions) were enrolled. At follow-up (22.8 ± 13.6 months), 8.6% MACEs, 3.4% cardiac death, 3.4% any MI, 4.7% TVR and 2.3% overall ST (definite/probable ST 1.3%) rates were reported, without differences between ≤ 15-day and >15-day DAT groups. At Cox multivariable-adjusted regression analysis (Hosmer-Lemeshow statistic, p=0.50) female sex, diabetes, previous PCI history, 15 days). |
| doi_str_mv | 10.1016/j.ijcard.2012.03.052 |
| format | Article |
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Consecutive patients without ≤ 12-month revascularization history, known statins allergy, known hypersensitivity reaction or previous or concomitant monoclonal and/or recombinant antibodies therapy, treated with single- or multivessel PCI plus GRS, were prospectively enrolled, at four PCI centers. Major adverse cardiac events (MACEs), the composite of cardiac death, any myocardial infarction (MI) and target vessel revascularization (TVR), and stent thrombosis (ST) cumulative incidences were evaluated.
Between March 2008 and March 2010, 384 patients (70.3% male, 423 lesions) were enrolled. At follow-up (22.8 ± 13.6 months), 8.6% MACEs, 3.4% cardiac death, 3.4% any MI, 4.7% TVR and 2.3% overall ST (definite/probable ST 1.3%) rates were reported, without differences between ≤ 15-day and >15-day DAT groups. At Cox multivariable-adjusted regression analysis (Hosmer-Lemeshow statistic, p=0.50) female sex, diabetes, previous PCI history, <45% left ventricular ejection fraction at admission and lesion length were identified as independent MACE predictors. DAT time duration (hazard ratio 1.98; 95% confidence interval 0.57-6.80, p=0.27) was not independent risk factor for MACEs.
In consecutive, prospectively enrolled patients with PCI indication and known or supposed low compliance to long-term DAT, GRS implantation might be a safe and effective option regardless of DAT duration after stenting (≤ 15 days or >15 days).</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2012.03.052</identifier><identifier>PMID: 22459371</identifier><identifier>CODEN: IJCDD5</identifier><language>eng</language><publisher>Shannon: Elsevier</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Cardiology. Vascular system ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - surgery ; Coronary heart disease ; Diseases of the cardiovascular system ; Female ; Heart ; Humans ; Male ; Medical sciences ; Middle Aged ; Percutaneous Coronary Intervention - methods ; Platelet Aggregation Inhibitors - administration & dosage ; Prospective Studies ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Registries ; Stents ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Treatment Outcome</subject><ispartof>International journal of cardiology, 2013-08, Vol.167 (3), p.757-761</ispartof><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27649364$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22459371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CASSESE, Salvatore</creatorcontrib><creatorcontrib>GALASSO, Gennaro</creatorcontrib><creatorcontrib>PISCIONE, Federico</creatorcontrib><creatorcontrib>SCIAHBASI, Alessandro</creatorcontrib><creatorcontrib>SCACCIATELLA, Paolo</creatorcontrib><creatorcontrib>MUCAJ, Andi</creatorcontrib><creatorcontrib>PICCOLO, Raffaele</creatorcontrib><creatorcontrib>D'ANNA, Carolina</creatorcontrib><creatorcontrib>PANGRAZI, Alberta</creatorcontrib><creatorcontrib>LIOY, Ernesto</creatorcontrib><creatorcontrib>MARRA, Sebastiano</creatorcontrib><title>Antiplatelet therapy after Genous EPC-capturing coroNary stenT implantatiOn The ARGENTO Study: a prospective, multicenter registry</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>To investigate the safety and efficacy of Genous Bio-engineered R stent (GRS) with ≤ 15-day or >15-day dual antiplatelet therapy (DAT), in patients undergoing percutaneous coronary intervention (PCI), with known or expected low compliance to long-term DAT (Antiplatelet theRapy after Genous EPC-capturing coroNary stenT implantatiOn--ARGENTO study).
Consecutive patients without ≤ 12-month revascularization history, known statins allergy, known hypersensitivity reaction or previous or concomitant monoclonal and/or recombinant antibodies therapy, treated with single- or multivessel PCI plus GRS, were prospectively enrolled, at four PCI centers. Major adverse cardiac events (MACEs), the composite of cardiac death, any myocardial infarction (MI) and target vessel revascularization (TVR), and stent thrombosis (ST) cumulative incidences were evaluated.
Between March 2008 and March 2010, 384 patients (70.3% male, 423 lesions) were enrolled. At follow-up (22.8 ± 13.6 months), 8.6% MACEs, 3.4% cardiac death, 3.4% any MI, 4.7% TVR and 2.3% overall ST (definite/probable ST 1.3%) rates were reported, without differences between ≤ 15-day and >15-day DAT groups. At Cox multivariable-adjusted regression analysis (Hosmer-Lemeshow statistic, p=0.50) female sex, diabetes, previous PCI history, <45% left ventricular ejection fraction at admission and lesion length were identified as independent MACE predictors. DAT time duration (hazard ratio 1.98; 95% confidence interval 0.57-6.80, p=0.27) was not independent risk factor for MACEs.
In consecutive, prospectively enrolled patients with PCI indication and known or supposed low compliance to long-term DAT, GRS implantation might be a safe and effective option regardless of DAT duration after stenting (≤ 15 days or >15 days).</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - surgery</subject><subject>Coronary heart disease</subject><subject>Diseases of the cardiovascular system</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Percutaneous Coronary Intervention - methods</subject><subject>Platelet Aggregation Inhibitors - administration & dosage</subject><subject>Prospective Studies</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Registries</subject><subject>Stents</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Treatment Outcome</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFLwzAYhoMoOqf_QCQXwYOtSZo2rbcx5hTGJjrPI0u_bBltV5NU6NVfbsSJp-_yvC_v8yF0RUlMCc3ud7HZKWnLmBHKYpLEJGVHaEBzwSMqUn6MBgETUcpEcobOndsRQnhR5KfojDGeFomgA_Q1arxpK-mhAo_9Fqxseyy1B4un0Ow7hycv40jJ1nfWNBus9nY_l7bHzkOzxKYO4cZLbxYNXm4Bj16nk_lygd98V_YPWOLW7l0LyptPuMN1V3mjoPmpt7Axztv-Ap1oWTm4PNwhen-cLMdP0WwxfR6PZlHLOPVRQiQQpdOMlrkmRNJSraXSYr0WjFLOC0ESUvJSC14KrbUqFCFUFmnGOATzZIhuf3vDoo8OnF_Vximown4InivKaZYVaZ7lAb0-oN26hnLVWlMH59Xf3wJwcwCkU7LSVjbKuH9OZLxIMp58A3tVgDE</recordid><startdate>20130810</startdate><enddate>20130810</enddate><creator>CASSESE, Salvatore</creator><creator>GALASSO, Gennaro</creator><creator>PISCIONE, Federico</creator><creator>SCIAHBASI, Alessandro</creator><creator>SCACCIATELLA, Paolo</creator><creator>MUCAJ, Andi</creator><creator>PICCOLO, Raffaele</creator><creator>D'ANNA, Carolina</creator><creator>PANGRAZI, Alberta</creator><creator>LIOY, Ernesto</creator><creator>MARRA, Sebastiano</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20130810</creationdate><title>Antiplatelet therapy after Genous EPC-capturing coroNary stenT implantatiOn The ARGENTO Study: a prospective, multicenter registry</title><author>CASSESE, Salvatore ; GALASSO, Gennaro ; PISCIONE, Federico ; SCIAHBASI, Alessandro ; SCACCIATELLA, Paolo ; MUCAJ, Andi ; PICCOLO, Raffaele ; D'ANNA, Carolina ; PANGRAZI, Alberta ; LIOY, Ernesto ; MARRA, Sebastiano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p241t-30ae0cf561d8f00a1dcbacf7bb72114497030d4df74d7fffc9c001a95624e0043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - surgery</topic><topic>Coronary heart disease</topic><topic>Diseases of the cardiovascular system</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Percutaneous Coronary Intervention - methods</topic><topic>Platelet Aggregation Inhibitors - administration & dosage</topic><topic>Prospective Studies</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Registries</topic><topic>Stents</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CASSESE, Salvatore</creatorcontrib><creatorcontrib>GALASSO, Gennaro</creatorcontrib><creatorcontrib>PISCIONE, Federico</creatorcontrib><creatorcontrib>SCIAHBASI, Alessandro</creatorcontrib><creatorcontrib>SCACCIATELLA, Paolo</creatorcontrib><creatorcontrib>MUCAJ, Andi</creatorcontrib><creatorcontrib>PICCOLO, Raffaele</creatorcontrib><creatorcontrib>D'ANNA, Carolina</creatorcontrib><creatorcontrib>PANGRAZI, Alberta</creatorcontrib><creatorcontrib>LIOY, Ernesto</creatorcontrib><creatorcontrib>MARRA, Sebastiano</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CASSESE, Salvatore</au><au>GALASSO, Gennaro</au><au>PISCIONE, Federico</au><au>SCIAHBASI, Alessandro</au><au>SCACCIATELLA, Paolo</au><au>MUCAJ, Andi</au><au>PICCOLO, Raffaele</au><au>D'ANNA, Carolina</au><au>PANGRAZI, Alberta</au><au>LIOY, Ernesto</au><au>MARRA, Sebastiano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiplatelet therapy after Genous EPC-capturing coroNary stenT implantatiOn The ARGENTO Study: a prospective, multicenter registry</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2013-08-10</date><risdate>2013</risdate><volume>167</volume><issue>3</issue><spage>757</spage><epage>761</epage><pages>757-761</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><coden>IJCDD5</coden><abstract>To investigate the safety and efficacy of Genous Bio-engineered R stent (GRS) with ≤ 15-day or >15-day dual antiplatelet therapy (DAT), in patients undergoing percutaneous coronary intervention (PCI), with known or expected low compliance to long-term DAT (Antiplatelet theRapy after Genous EPC-capturing coroNary stenT implantatiOn--ARGENTO study).
Consecutive patients without ≤ 12-month revascularization history, known statins allergy, known hypersensitivity reaction or previous or concomitant monoclonal and/or recombinant antibodies therapy, treated with single- or multivessel PCI plus GRS, were prospectively enrolled, at four PCI centers. Major adverse cardiac events (MACEs), the composite of cardiac death, any myocardial infarction (MI) and target vessel revascularization (TVR), and stent thrombosis (ST) cumulative incidences were evaluated.
Between March 2008 and March 2010, 384 patients (70.3% male, 423 lesions) were enrolled. At follow-up (22.8 ± 13.6 months), 8.6% MACEs, 3.4% cardiac death, 3.4% any MI, 4.7% TVR and 2.3% overall ST (definite/probable ST 1.3%) rates were reported, without differences between ≤ 15-day and >15-day DAT groups. At Cox multivariable-adjusted regression analysis (Hosmer-Lemeshow statistic, p=0.50) female sex, diabetes, previous PCI history, <45% left ventricular ejection fraction at admission and lesion length were identified as independent MACE predictors. DAT time duration (hazard ratio 1.98; 95% confidence interval 0.57-6.80, p=0.27) was not independent risk factor for MACEs.
In consecutive, prospectively enrolled patients with PCI indication and known or supposed low compliance to long-term DAT, GRS implantation might be a safe and effective option regardless of DAT duration after stenting (≤ 15 days or >15 days).</abstract><cop>Shannon</cop><pub>Elsevier</pub><pmid>22459371</pmid><doi>10.1016/j.ijcard.2012.03.052</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-5273 |
| ispartof | International journal of cardiology, 2013-08, Vol.167 (3), p.757-761 |
| issn | 0167-5273 1874-1754 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aged Aged, 80 and over Biological and medical sciences Cardiology. Vascular system Coronary Artery Disease - diagnosis Coronary Artery Disease - epidemiology Coronary Artery Disease - surgery Coronary heart disease Diseases of the cardiovascular system Female Heart Humans Male Medical sciences Middle Aged Percutaneous Coronary Intervention - methods Platelet Aggregation Inhibitors - administration & dosage Prospective Studies Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Registries Stents Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Treatment Outcome |
| title | Antiplatelet therapy after Genous EPC-capturing coroNary stenT implantatiOn The ARGENTO Study: a prospective, multicenter registry |
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