Effects of a 12-week home-based exercise program on the level of physical activity, insulin, and cytokines in colorectal cancer survivors: a pilot study
Purpose The purposes of this study are to examine (1) the feasibility and efficacy of two different home-based exercise protocols on the level of physical activity (PA), and (2) the effect of increased PA via home-based exercise program on biomarkers of colorectal cancer. Methods Seventeen patients...
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| Veröffentlicht in: | Supportive care in cancer 2013-09, Vol.21 (9), p.2537-2545 |
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| creator | Lee, Dong Hoon Kim, Ji Young Lee, Mi Kyung Lee, Choae Min, Ji-Hee Jeong, Duck Hyoun Lee, Ji-Won Chu, Sang Hui Meyerhardt, Jeffrey A. Ligibel, Jennifer Jones, Lee W. Kim, Nam Kyu Jeon, Justin Y. |
| description | Purpose
The purposes of this study are to examine (1) the feasibility and efficacy of two different home-based exercise protocols on the level of physical activity (PA), and (2) the effect of increased PA via home-based exercise program on biomarkers of colorectal cancer.
Methods
Seventeen patients (age 55.18 ± 13.3 years) with stage II–III colorectal cancer completed the 12-week home-based exercise program. Subjects were randomized into either casually intervened home-based exercise group (CIHE) or intensely intervened home-based exercise group (IIHE). The primary outcome was the level of PA. Furthermore, insulin, homeostasis model assessment of insulin resistance, insulin-like growth factor axis, and adipocytokines were measured.
Results
Both CIHE and IIHE program significantly increased the level of PA at 12 weeks compared to its level at baseline (CIHE, 10.00 ± 8.49 vs. 46.07 ± 45.59; IIHE, 12.08 ± 11.04 vs. 35.42 ± 27.42 MET hours per week). Since there was no difference in PA change between groups (
p
= 0.511), the data was combined in analyzing the effects of increased PA on biomarkers. Increase in PA significantly reduced insulin (6.66 ± 4.58 vs. 4.86 ± 3.48 μU/ml,
p
= 0.006), HOMA-IR (1.66 ± 1.23 vs. 1.25 ± 1.04,
p
= 0.017), and tumor necrosis alpha-α (TNF-α 4.85 ± 7.88 vs. 2.95 ± 5.38 pg/ml,
p
= 0.004), and significantly increased IGF-1 (135.39 ± 60.15 vs. 159.53 ng/ml,
p
= 0.007), IGF binding protein (IGFBP)-3 (2.67 ± 1.48 vs. 3.48 ± 1.00 ng/ml,
p
= 0.013), and adiponectin (6.73 ± 3.07 vs. 7.54 ± 3.96 μg/ml,
p
= 0.015).
Conclusion
CIHE program was as effective as IIHE program in increasing the level of PA, and the increase in PA resulted in significant change in HOMA-IR, IGF-1 axis, TNF-α, and adiponectin levels in stage II–III colorectal cancer survivors. |
| doi_str_mv | 10.1007/s00520-013-1822-7 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1416695746</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A571419328</galeid><sourcerecordid>A571419328</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-ac29ef426564161827dd7097344778d1b112bee8e38e903b471174d8242eca1e3</originalsourceid><addsrcrecordid>eNqNks1u1DAUhSMEokPhAdggS2xY1MW_ccJuVLWAVIkNrC2PczPjNrEH2xnIm_C4dTQFKgQS8sKS_Z1zf3Sq6iUl55QQ9TYRIhnBhHJMG8awelStqOAcK87bx9WKtIJiwaU8qZ6ldEMIVUqyp9UJ4zWva9Guqh-XfQ82JxR6ZBBl-BvALdqFEfDGJOgQfIdoXQK0j2EbzYiCR3kHaIADDItqv5uTs2ZAxmZ3cHk-Q86naXD-DBnfITvncOs8pPKMbBhCLPUKbo23EFGa4sEdQkzvSv29G0JGKU_d_Lx60pshwYv7-7T6cnX5-eIDvv70_uPF-hpboZqMjWUt9ILVsha0LltQXadIq7gQSjUd3VDKNgAN8AZawjdCUapE1zDBwBoK_LR6c_Qt832dIGU9umRhGIyHMCVNi23dSiXqgr7-A70JU_Slu4WSslaNbH9TWzOAdr4PORq7mOr10hXhDSGFOv8LVU4Ho7PBQ-_K-1qq4txy1vyv4GEFehTYGFKK0Ot9dKOJs6ZEL_HRx_joEh-9xEeronl1P-G0GaH7pfiZlwKwI5DKl99CfLCCf7reAXzvzak</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1415567859</pqid></control><display><type>article</type><title>Effects of a 12-week home-based exercise program on the level of physical activity, insulin, and cytokines in colorectal cancer survivors: a pilot study</title><source>MEDLINE</source><source>Springer Online Journals Complete</source><creator>Lee, Dong Hoon ; Kim, Ji Young ; Lee, Mi Kyung ; Lee, Choae ; Min, Ji-Hee ; Jeong, Duck Hyoun ; Lee, Ji-Won ; Chu, Sang Hui ; Meyerhardt, Jeffrey A. ; Ligibel, Jennifer ; Jones, Lee W. ; Kim, Nam Kyu ; Jeon, Justin Y.</creator><creatorcontrib>Lee, Dong Hoon ; Kim, Ji Young ; Lee, Mi Kyung ; Lee, Choae ; Min, Ji-Hee ; Jeong, Duck Hyoun ; Lee, Ji-Won ; Chu, Sang Hui ; Meyerhardt, Jeffrey A. ; Ligibel, Jennifer ; Jones, Lee W. ; Kim, Nam Kyu ; Jeon, Justin Y.</creatorcontrib><description>Purpose
The purposes of this study are to examine (1) the feasibility and efficacy of two different home-based exercise protocols on the level of physical activity (PA), and (2) the effect of increased PA via home-based exercise program on biomarkers of colorectal cancer.
Methods
Seventeen patients (age 55.18 ± 13.3 years) with stage II–III colorectal cancer completed the 12-week home-based exercise program. Subjects were randomized into either casually intervened home-based exercise group (CIHE) or intensely intervened home-based exercise group (IIHE). The primary outcome was the level of PA. Furthermore, insulin, homeostasis model assessment of insulin resistance, insulin-like growth factor axis, and adipocytokines were measured.
Results
Both CIHE and IIHE program significantly increased the level of PA at 12 weeks compared to its level at baseline (CIHE, 10.00 ± 8.49 vs. 46.07 ± 45.59; IIHE, 12.08 ± 11.04 vs. 35.42 ± 27.42 MET hours per week). Since there was no difference in PA change between groups (
p
= 0.511), the data was combined in analyzing the effects of increased PA on biomarkers. Increase in PA significantly reduced insulin (6.66 ± 4.58 vs. 4.86 ± 3.48 μU/ml,
p
= 0.006), HOMA-IR (1.66 ± 1.23 vs. 1.25 ± 1.04,
p
= 0.017), and tumor necrosis alpha-α (TNF-α 4.85 ± 7.88 vs. 2.95 ± 5.38 pg/ml,
p
= 0.004), and significantly increased IGF-1 (135.39 ± 60.15 vs. 159.53 ng/ml,
p
= 0.007), IGF binding protein (IGFBP)-3 (2.67 ± 1.48 vs. 3.48 ± 1.00 ng/ml,
p
= 0.013), and adiponectin (6.73 ± 3.07 vs. 7.54 ± 3.96 μg/ml,
p
= 0.015).
Conclusion
CIHE program was as effective as IIHE program in increasing the level of PA, and the increase in PA resulted in significant change in HOMA-IR, IGF-1 axis, TNF-α, and adiponectin levels in stage II–III colorectal cancer survivors.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-013-1822-7</identifier><identifier>PMID: 23636649</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Biological markers ; Biomarkers ; Biomarkers - blood ; Cancer ; Cancer research ; Cancer survivors ; Cholesterol ; Colorectal cancer ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - physiopathology ; Colorectal Neoplasms - rehabilitation ; Cytokines ; Cytokines - blood ; Exercise ; Exercise - physiology ; Exercise Therapy - methods ; Female ; Homeostasis ; Humans ; Insulin ; Insulin - blood ; Insulin resistance ; Insulin Resistance - physiology ; Insulin-Like Growth Factor Binding Protein 3 - blood ; Insulin-Like Growth Factor I - metabolism ; Male ; Medicine & Public Health ; Middle Aged ; Motor Activity - physiology ; Necrosis ; Nursing ; Nursing Research ; Oncology ; Oncology, Experimental ; Original Article ; Pain Medicine ; Physical fitness ; Pilot Projects ; Protein binding ; Rehabilitation Medicine ; Survivor ; Survivors ; Treatment Outcome ; Tumor Necrosis Factor-alpha ; Tumors</subject><ispartof>Supportive care in cancer, 2013-09, Vol.21 (9), p.2537-2545</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-ac29ef426564161827dd7097344778d1b112bee8e38e903b471174d8242eca1e3</citedby><cites>FETCH-LOGICAL-c478t-ac29ef426564161827dd7097344778d1b112bee8e38e903b471174d8242eca1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-013-1822-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-013-1822-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23636649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Dong Hoon</creatorcontrib><creatorcontrib>Kim, Ji Young</creatorcontrib><creatorcontrib>Lee, Mi Kyung</creatorcontrib><creatorcontrib>Lee, Choae</creatorcontrib><creatorcontrib>Min, Ji-Hee</creatorcontrib><creatorcontrib>Jeong, Duck Hyoun</creatorcontrib><creatorcontrib>Lee, Ji-Won</creatorcontrib><creatorcontrib>Chu, Sang Hui</creatorcontrib><creatorcontrib>Meyerhardt, Jeffrey A.</creatorcontrib><creatorcontrib>Ligibel, Jennifer</creatorcontrib><creatorcontrib>Jones, Lee W.</creatorcontrib><creatorcontrib>Kim, Nam Kyu</creatorcontrib><creatorcontrib>Jeon, Justin Y.</creatorcontrib><title>Effects of a 12-week home-based exercise program on the level of physical activity, insulin, and cytokines in colorectal cancer survivors: a pilot study</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
The purposes of this study are to examine (1) the feasibility and efficacy of two different home-based exercise protocols on the level of physical activity (PA), and (2) the effect of increased PA via home-based exercise program on biomarkers of colorectal cancer.
Methods
Seventeen patients (age 55.18 ± 13.3 years) with stage II–III colorectal cancer completed the 12-week home-based exercise program. Subjects were randomized into either casually intervened home-based exercise group (CIHE) or intensely intervened home-based exercise group (IIHE). The primary outcome was the level of PA. Furthermore, insulin, homeostasis model assessment of insulin resistance, insulin-like growth factor axis, and adipocytokines were measured.
Results
Both CIHE and IIHE program significantly increased the level of PA at 12 weeks compared to its level at baseline (CIHE, 10.00 ± 8.49 vs. 46.07 ± 45.59; IIHE, 12.08 ± 11.04 vs. 35.42 ± 27.42 MET hours per week). Since there was no difference in PA change between groups (
p
= 0.511), the data was combined in analyzing the effects of increased PA on biomarkers. Increase in PA significantly reduced insulin (6.66 ± 4.58 vs. 4.86 ± 3.48 μU/ml,
p
= 0.006), HOMA-IR (1.66 ± 1.23 vs. 1.25 ± 1.04,
p
= 0.017), and tumor necrosis alpha-α (TNF-α 4.85 ± 7.88 vs. 2.95 ± 5.38 pg/ml,
p
= 0.004), and significantly increased IGF-1 (135.39 ± 60.15 vs. 159.53 ng/ml,
p
= 0.007), IGF binding protein (IGFBP)-3 (2.67 ± 1.48 vs. 3.48 ± 1.00 ng/ml,
p
= 0.013), and adiponectin (6.73 ± 3.07 vs. 7.54 ± 3.96 μg/ml,
p
= 0.015).
Conclusion
CIHE program was as effective as IIHE program in increasing the level of PA, and the increase in PA resulted in significant change in HOMA-IR, IGF-1 axis, TNF-α, and adiponectin levels in stage II–III colorectal cancer survivors.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Cancer survivors</subject><subject>Cholesterol</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - physiopathology</subject><subject>Colorectal Neoplasms - rehabilitation</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Exercise Therapy - methods</subject><subject>Female</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Insulin-Like Growth Factor Binding Protein 3 - blood</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Male</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Motor Activity - physiology</subject><subject>Necrosis</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Oncology, Experimental</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Physical fitness</subject><subject>Pilot Projects</subject><subject>Protein binding</subject><subject>Rehabilitation Medicine</subject><subject>Survivor</subject><subject>Survivors</subject><subject>Treatment Outcome</subject><subject>Tumor Necrosis Factor-alpha</subject><subject>Tumors</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNks1u1DAUhSMEokPhAdggS2xY1MW_ccJuVLWAVIkNrC2PczPjNrEH2xnIm_C4dTQFKgQS8sKS_Z1zf3Sq6iUl55QQ9TYRIhnBhHJMG8awelStqOAcK87bx9WKtIJiwaU8qZ6ldEMIVUqyp9UJ4zWva9Guqh-XfQ82JxR6ZBBl-BvALdqFEfDGJOgQfIdoXQK0j2EbzYiCR3kHaIADDItqv5uTs2ZAxmZ3cHk-Q86naXD-DBnfITvncOs8pPKMbBhCLPUKbo23EFGa4sEdQkzvSv29G0JGKU_d_Lx60pshwYv7-7T6cnX5-eIDvv70_uPF-hpboZqMjWUt9ILVsha0LltQXadIq7gQSjUd3VDKNgAN8AZawjdCUapE1zDBwBoK_LR6c_Qt832dIGU9umRhGIyHMCVNi23dSiXqgr7-A70JU_Slu4WSslaNbH9TWzOAdr4PORq7mOr10hXhDSGFOv8LVU4Ho7PBQ-_K-1qq4txy1vyv4GEFehTYGFKK0Ot9dKOJs6ZEL_HRx_joEh-9xEeronl1P-G0GaH7pfiZlwKwI5DKl99CfLCCf7reAXzvzak</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Lee, Dong Hoon</creator><creator>Kim, Ji Young</creator><creator>Lee, Mi Kyung</creator><creator>Lee, Choae</creator><creator>Min, Ji-Hee</creator><creator>Jeong, Duck Hyoun</creator><creator>Lee, Ji-Won</creator><creator>Chu, Sang Hui</creator><creator>Meyerhardt, Jeffrey A.</creator><creator>Ligibel, Jennifer</creator><creator>Jones, Lee W.</creator><creator>Kim, Nam Kyu</creator><creator>Jeon, Justin Y.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20130901</creationdate><title>Effects of a 12-week home-based exercise program on the level of physical activity, insulin, and cytokines in colorectal cancer survivors: a pilot study</title><author>Lee, Dong Hoon ; Kim, Ji Young ; Lee, Mi Kyung ; Lee, Choae ; Min, Ji-Hee ; Jeong, Duck Hyoun ; Lee, Ji-Won ; Chu, Sang Hui ; Meyerhardt, Jeffrey A. ; Ligibel, Jennifer ; Jones, Lee W. ; Kim, Nam Kyu ; Jeon, Justin Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-ac29ef426564161827dd7097344778d1b112bee8e38e903b471174d8242eca1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Cancer</topic><topic>Cancer research</topic><topic>Cancer survivors</topic><topic>Cholesterol</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - physiopathology</topic><topic>Colorectal Neoplasms - rehabilitation</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Exercise Therapy - methods</topic><topic>Female</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Insulin-Like Growth Factor Binding Protein 3 - blood</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Male</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Motor Activity - physiology</topic><topic>Necrosis</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Oncology, Experimental</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Physical fitness</topic><topic>Pilot Projects</topic><topic>Protein binding</topic><topic>Rehabilitation Medicine</topic><topic>Survivor</topic><topic>Survivors</topic><topic>Treatment Outcome</topic><topic>Tumor Necrosis Factor-alpha</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Dong Hoon</creatorcontrib><creatorcontrib>Kim, Ji Young</creatorcontrib><creatorcontrib>Lee, Mi Kyung</creatorcontrib><creatorcontrib>Lee, Choae</creatorcontrib><creatorcontrib>Min, Ji-Hee</creatorcontrib><creatorcontrib>Jeong, Duck Hyoun</creatorcontrib><creatorcontrib>Lee, Ji-Won</creatorcontrib><creatorcontrib>Chu, Sang Hui</creatorcontrib><creatorcontrib>Meyerhardt, Jeffrey A.</creatorcontrib><creatorcontrib>Ligibel, Jennifer</creatorcontrib><creatorcontrib>Jones, Lee W.</creatorcontrib><creatorcontrib>Kim, Nam Kyu</creatorcontrib><creatorcontrib>Jeon, Justin Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Dong Hoon</au><au>Kim, Ji Young</au><au>Lee, Mi Kyung</au><au>Lee, Choae</au><au>Min, Ji-Hee</au><au>Jeong, Duck Hyoun</au><au>Lee, Ji-Won</au><au>Chu, Sang Hui</au><au>Meyerhardt, Jeffrey A.</au><au>Ligibel, Jennifer</au><au>Jones, Lee W.</au><au>Kim, Nam Kyu</au><au>Jeon, Justin Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of a 12-week home-based exercise program on the level of physical activity, insulin, and cytokines in colorectal cancer survivors: a pilot study</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>21</volume><issue>9</issue><spage>2537</spage><epage>2545</epage><pages>2537-2545</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Purpose
The purposes of this study are to examine (1) the feasibility and efficacy of two different home-based exercise protocols on the level of physical activity (PA), and (2) the effect of increased PA via home-based exercise program on biomarkers of colorectal cancer.
Methods
Seventeen patients (age 55.18 ± 13.3 years) with stage II–III colorectal cancer completed the 12-week home-based exercise program. Subjects were randomized into either casually intervened home-based exercise group (CIHE) or intensely intervened home-based exercise group (IIHE). The primary outcome was the level of PA. Furthermore, insulin, homeostasis model assessment of insulin resistance, insulin-like growth factor axis, and adipocytokines were measured.
Results
Both CIHE and IIHE program significantly increased the level of PA at 12 weeks compared to its level at baseline (CIHE, 10.00 ± 8.49 vs. 46.07 ± 45.59; IIHE, 12.08 ± 11.04 vs. 35.42 ± 27.42 MET hours per week). Since there was no difference in PA change between groups (
p
= 0.511), the data was combined in analyzing the effects of increased PA on biomarkers. Increase in PA significantly reduced insulin (6.66 ± 4.58 vs. 4.86 ± 3.48 μU/ml,
p
= 0.006), HOMA-IR (1.66 ± 1.23 vs. 1.25 ± 1.04,
p
= 0.017), and tumor necrosis alpha-α (TNF-α 4.85 ± 7.88 vs. 2.95 ± 5.38 pg/ml,
p
= 0.004), and significantly increased IGF-1 (135.39 ± 60.15 vs. 159.53 ng/ml,
p
= 0.007), IGF binding protein (IGFBP)-3 (2.67 ± 1.48 vs. 3.48 ± 1.00 ng/ml,
p
= 0.013), and adiponectin (6.73 ± 3.07 vs. 7.54 ± 3.96 μg/ml,
p
= 0.015).
Conclusion
CIHE program was as effective as IIHE program in increasing the level of PA, and the increase in PA resulted in significant change in HOMA-IR, IGF-1 axis, TNF-α, and adiponectin levels in stage II–III colorectal cancer survivors.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23636649</pmid><doi>10.1007/s00520-013-1822-7</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0941-4355 |
| ispartof | Supportive care in cancer, 2013-09, Vol.21 (9), p.2537-2545 |
| issn | 0941-4355 1433-7339 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1416695746 |
| source | MEDLINE; Springer Online Journals Complete |
| subjects | Adult Aged Biological markers Biomarkers Biomarkers - blood Cancer Cancer research Cancer survivors Cholesterol Colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - physiopathology Colorectal Neoplasms - rehabilitation Cytokines Cytokines - blood Exercise Exercise - physiology Exercise Therapy - methods Female Homeostasis Humans Insulin Insulin - blood Insulin resistance Insulin Resistance - physiology Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor I - metabolism Male Medicine & Public Health Middle Aged Motor Activity - physiology Necrosis Nursing Nursing Research Oncology Oncology, Experimental Original Article Pain Medicine Physical fitness Pilot Projects Protein binding Rehabilitation Medicine Survivor Survivors Treatment Outcome Tumor Necrosis Factor-alpha Tumors |
| title | Effects of a 12-week home-based exercise program on the level of physical activity, insulin, and cytokines in colorectal cancer survivors: a pilot study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T17%3A38%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20a%2012-week%20home-based%20exercise%20program%20on%20the%20level%20of%20physical%20activity,%20insulin,%20and%20cytokines%20in%20colorectal%20cancer%20survivors:%20a%20pilot%20study&rft.jtitle=Supportive%20care%20in%20cancer&rft.au=Lee,%20Dong%20Hoon&rft.date=2013-09-01&rft.volume=21&rft.issue=9&rft.spage=2537&rft.epage=2545&rft.pages=2537-2545&rft.issn=0941-4355&rft.eissn=1433-7339&rft_id=info:doi/10.1007/s00520-013-1822-7&rft_dat=%3Cgale_proqu%3EA571419328%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1415567859&rft_id=info:pmid/23636649&rft_galeid=A571419328&rfr_iscdi=true |