Polyethyleneglycol crosslinked N-(2-hydroxyethyl)-polyethylenimine nanoparticles as efficient non-viral vectors for DNA and siRNA delivery in vitro and in vivo

A series of electrostatically crosslinked nanoparticles, N-(2-hydroxyethyl)-polyethylenimine-PEG600 (HePP), was prepared by allowing N-(2-hydroxyethyl)-polyethylenimine (HeP) to interact with polyethyleneglycol (600) dicarboxylic acid (HOOC-PEG600-COOH, PEG600dc), they were then evaluated for their...

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Veröffentlicht in:	Molecular bioSystems 2013-01, Vol.9 (9), p.2322-2330
Hauptverfasser:	Tripathi, Sushil K, Gupta, Kailash C, Kumar, Pradeep
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Survival - drug effects DNA - chemistry Gene Transfer Techniques Humans Nanoparticles - administration & dosage Nanoparticles - chemistry Nanoparticles - toxicity Particle Size Polyethylene Glycols - chemistry Polyethyleneimine - chemistry RNA, Small Interfering - chemistry
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