TALE-mediated modulation of transcriptional enhancers in vivo

Transcription activator–like effectors are used for in vivo activation and repression of endogenous promoters and enhancers in the fruit fly. We tested whether transcription activator–like effectors (TALEs) could mediate repression and activation of endogenous enhancers in the Drosophila genome. TAL...

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Veröffentlicht in:	Nature methods 2013-08, Vol.10 (8), p.762-767
Hauptverfasser:	Crocker, Justin, Stern, David L
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/1511 631/1647/1513/1967/2316 631/208/200 631/337/572 Analysis Animals Bioassays Bioinformatics Biological Microscopy Biological Techniques Biomedical Engineering/Biotechnology Deoxyribonucleic acid DNA Drosophila Drosophila melanogaster - genetics Drosophila Proteins - genetics Enhancer Elements, Genetic Female Gene expression Gene Expression Regulation, Developmental Genetic aspects Genetic transcription Genome, Insect Genomes Genomics Homeodomain Proteins - genetics Insects Larvae Life Sciences Male Microscopy, Confocal Organisms, Genetically Modified Proteins Proteomics Transcription Factors - genetics Transcriptional Activation
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