Effects of methapyrilene on rat hepatic xenobiotic metabolizing enzymes and liver morphology

Short-term treatment of rats with hepatocarcinogens elicits a consistent pattern of phenotypic changes in hepatic drug metabolizing enzymes, the most striking of which is a marked increase in microsomal epoxide hydrolase (EH) activity. The antihistaminic drug methapyrilene induces a high incidence o...

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Veröffentlicht in:	Fundamental and applied toxicology 1985-01, Vol.5 (1), p.165-174
Hauptverfasser:	Graichen, M.Elizabeth, Neptun, Douglas A., Dent, John G., Popp, James A., Leonard, Thomas B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Aminopyridines - toxicity Animals Bile Acids and Salts - metabolism Bile Ducts - pathology Chemical and Drug Induced Liver Injury Epoxide Hydrolases - metabolism gamma-Glutamyltransferase - blood Liver Diseases - enzymology Liver Diseases - pathology Liver Function Tests Male Methapyrilene - toxicity Microsomes, Liver - enzymology Mixed Function Oxygenases - metabolism Necrosis Rats Rats, Inbred F344
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