Ethanol-induced alterations in rat synaptosomal plasma membrane phospholipids. Relationship to changes in the phospholipid methyltransferases

The effects of ethanol ingestion on the lipids of the synaptic plasma membrane (SPM) have been measured and correlated with the time frame for the development of physical dependence. Alterations were observed in three of the phospholipid fractions: phosphatidylcholine (PC) increased, and the phospha...

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Veröffentlicht in:	Molecular pharmacology 1985-02, Vol.27 (2), p.256-262
Hauptverfasser:	MAGRUDER, J. D, WAID-JONES, M, REITZ, R. C
Format:	Artikel
Sprache:	eng
Schlagworte:	alcohol Alcoholism and acute alcohol poisoning Animals Biological and medical sciences brain ethanol Ethanol - toxicity Humans Kinetics Male Medical sciences Membrane Lipids - analysis Methylation Methyltransferases - analysis Phosphatidylethanolamine N-Methyltransferase phospholipid composition Phospholipids - analysis plasma membranes Rats S-Adenosylmethionine - metabolism Substance Withdrawal Syndrome - metabolism synaptosomes Synaptosomes - drug effects Toxicology
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