Chemical Exposures at Work and Cardiovascular Morbidity Atherosclerosis, Ischemic Heart Disease, Hypertension, Cardiomyopathy and Arrhythmias
Relatively little systematic research has been directed towards the potential effects, either etiologic or aggravating, of industrial chemicals on cardiovascular diseases. While some evidence indicates that exposure to certain pesticides might affect lipoprotein metabolism in man, there is no consis...
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Veröffentlicht in: | Scandinavian Journal of Work, Environment & Health Environment & Health, 1984-12, Vol.10 (6), p.381-388 |
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container_title | Scandinavian Journal of Work, Environment & Health |
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creator | Kurppa, Kari Hietanen, Eino Klockars, Matti Partinen, Markku Rantanen, Jorma Rönnemaa, Tapani Viikari, Jorma |
description | Relatively little systematic research has been directed towards the potential effects, either etiologic or aggravating, of industrial chemicals on cardiovascular diseases. While some evidence indicates that exposure to certain pesticides might affect lipoprotein metabolism in man, there is no consistent documentation to support the view that atherosclerosis is caused in man by chemical exposures in industry. In this respect results from some animal studies are highly interesting, eg, exposure to some carcinogens, but the hypotheses presented have not yet been vigorously tested in man. Exposure to carbon monoxide is detrimental to the myocardium, especially in patients with ischémie heart disease, but there are no reliable data on elevated cardiac mortality due to carbon monoxide exposure in industrial populations. A few studies have reported arrhythmias or sudden deaths among workers exposed to solvents and organic nitrates. The effects of lead and cadmium upon human blood pressure have remained controversial, although the bulk of controlled epidemiologic studies suggests that they, if at all existent, are not strong. |
doi_str_mv | 10.5271/sjweh.2316 |
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While some evidence indicates that exposure to certain pesticides might affect lipoprotein metabolism in man, there is no consistent documentation to support the view that atherosclerosis is caused in man by chemical exposures in industry. In this respect results from some animal studies are highly interesting, eg, exposure to some carcinogens, but the hypotheses presented have not yet been vigorously tested in man. Exposure to carbon monoxide is detrimental to the myocardium, especially in patients with ischémie heart disease, but there are no reliable data on elevated cardiac mortality due to carbon monoxide exposure in industrial populations. A few studies have reported arrhythmias or sudden deaths among workers exposed to solvents and organic nitrates. 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While some evidence indicates that exposure to certain pesticides might affect lipoprotein metabolism in man, there is no consistent documentation to support the view that atherosclerosis is caused in man by chemical exposures in industry. In this respect results from some animal studies are highly interesting, eg, exposure to some carcinogens, but the hypotheses presented have not yet been vigorously tested in man. Exposure to carbon monoxide is detrimental to the myocardium, especially in patients with ischémie heart disease, but there are no reliable data on elevated cardiac mortality due to carbon monoxide exposure in industrial populations. A few studies have reported arrhythmias or sudden deaths among workers exposed to solvents and organic nitrates. The effects of lead and cadmium upon human blood pressure have remained controversial, although the bulk of controlled epidemiologic studies suggests that they, if at all existent, are not strong.</description><subject>Animals</subject><subject>Arrhythmias, Cardiac - chemically induced</subject><subject>Arsenic - toxicity</subject><subject>Arteriosclerosis - chemically induced</subject><subject>Atherosclerosis</subject><subject>Blood pressure</subject><subject>Cadmium</subject><subject>Cadmium - toxicity</subject><subject>Carbon Disulfide - toxicity</subject><subject>Carbon monoxide</subject><subject>Carbon Monoxide - toxicity</subject><subject>Cardiomyopathies - chemically induced</subject><subject>Chemical hazards</subject><subject>Cobalt - toxicity</subject><subject>Coronary Disease - chemically induced</subject><subject>Disulfides</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Hydrocarbons, Halogenated - toxicity</subject><subject>Hypertension</subject><subject>Hypertension - chemically induced</subject><subject>Lead</subject><subject>Lead - toxicity</subject><subject>Metals - toxicity</subject><subject>Mortality</subject><subject>Nitrates - toxicity</subject><subject>Occupational Diseases - chemically induced</subject><subject>Pesticides - toxicity</subject><subject>Polycyclic Compounds - toxicity</subject><subject>Risk</subject><subject>Solvents - toxicity</subject><issn>0355-3140</issn><issn>1795-990X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUGP0zAQhS0EWsrChTuSTxxQs3jiOImPVVnoSou4gOBmOclEcUniYDtAfgT_GaetFnGwLes9vxl_Q8hLYDciLeCtP_7C7iblkD8iGyikSKRk3x6TDeNCJBwy9pQ88_7IWCrjgytylXNZSmAb8mff4WBq3dPb35P1s0NPdaBfrftO9djQvXaNsT-1r-deO_rRuso0Jix0Fzp01tf9uhu_pXe-PkXRA2oX6DvjUXvc0sMyoQs4emPH7SVvWOykQ7ecSuyc65bQDUb75-RJq3uPLy7nNfny_vbz_pDcf_pwt9_dJ1qwNCRYtUI2UEtsi7SoSpHmmOuCZUXKailAYMUqVhaoZZ63GaLmdQYSikxChpzza_L6nDs5-2NGH9RgfI19r0e0s1eQQc5KSKPxzdlYx196h62anBm0WxQwtbJXJ_ZqZR_Nry6pczVg82C9wP6nH32w7kHOmMxFlKN-OOvaOBOMOtrZjRGDWse4TlGBLDMAlTJgALFFiF38d-ElxFXyv6dUn8s</recordid><startdate>198412</startdate><enddate>198412</enddate><creator>Kurppa, Kari</creator><creator>Hietanen, Eino</creator><creator>Klockars, Matti</creator><creator>Partinen, Markku</creator><creator>Rantanen, Jorma</creator><creator>Rönnemaa, Tapani</creator><creator>Viikari, Jorma</creator><general>Scandinavian Journal of Work, Environment & Health</general><general>National Board of Occupational Safety and Health</general><general>The Working Environment Fund</general><general>Swedish Medical Society, Section for Environmental Health</general><general>Work Research Institutes</general><general>Institute of Occupational Health</general><scope>188</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>198412</creationdate><title>Chemical Exposures at Work and Cardiovascular Morbidity Atherosclerosis, Ischemic Heart Disease, Hypertension, Cardiomyopathy and Arrhythmias</title><author>Kurppa, Kari ; Hietanen, Eino ; Klockars, Matti ; Partinen, Markku ; Rantanen, Jorma ; Rönnemaa, Tapani ; Viikari, Jorma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a502t-ebf59d1c9ef727b8526e6a704720c9515eb0b087ea966f4eea3c419174914e333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Arrhythmias, Cardiac - chemically induced</topic><topic>Arsenic - toxicity</topic><topic>Arteriosclerosis - chemically induced</topic><topic>Atherosclerosis</topic><topic>Blood pressure</topic><topic>Cadmium</topic><topic>Cadmium - toxicity</topic><topic>Carbon Disulfide - toxicity</topic><topic>Carbon monoxide</topic><topic>Carbon Monoxide - toxicity</topic><topic>Cardiomyopathies - chemically induced</topic><topic>Chemical hazards</topic><topic>Cobalt - toxicity</topic><topic>Coronary Disease - chemically induced</topic><topic>Disulfides</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Hydrocarbons, Halogenated - toxicity</topic><topic>Hypertension</topic><topic>Hypertension - chemically induced</topic><topic>Lead</topic><topic>Lead - toxicity</topic><topic>Metals - toxicity</topic><topic>Mortality</topic><topic>Nitrates - toxicity</topic><topic>Occupational Diseases - chemically induced</topic><topic>Pesticides - toxicity</topic><topic>Polycyclic Compounds - toxicity</topic><topic>Risk</topic><topic>Solvents - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurppa, Kari</creatorcontrib><creatorcontrib>Hietanen, Eino</creatorcontrib><creatorcontrib>Klockars, Matti</creatorcontrib><creatorcontrib>Partinen, Markku</creatorcontrib><creatorcontrib>Rantanen, Jorma</creatorcontrib><creatorcontrib>Rönnemaa, Tapani</creatorcontrib><creatorcontrib>Viikari, Jorma</creatorcontrib><collection>Airiti Library</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Scandinavian Journal of Work, Environment & Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurppa, Kari</au><au>Hietanen, Eino</au><au>Klockars, Matti</au><au>Partinen, Markku</au><au>Rantanen, Jorma</au><au>Rönnemaa, Tapani</au><au>Viikari, Jorma</au><au>Kuppa, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical Exposures at Work and Cardiovascular Morbidity Atherosclerosis, Ischemic Heart Disease, Hypertension, Cardiomyopathy and Arrhythmias</atitle><jtitle>Scandinavian Journal of Work, Environment & Health</jtitle><addtitle>Scand J Work Environ Health</addtitle><date>1984-12</date><risdate>1984</risdate><volume>10</volume><issue>6</issue><spage>381</spage><epage>388</epage><pages>381-388</pages><issn>0355-3140</issn><eissn>1795-990X</eissn><abstract>Relatively little systematic research has been directed towards the potential effects, either etiologic or aggravating, of industrial chemicals on cardiovascular diseases. While some evidence indicates that exposure to certain pesticides might affect lipoprotein metabolism in man, there is no consistent documentation to support the view that atherosclerosis is caused in man by chemical exposures in industry. In this respect results from some animal studies are highly interesting, eg, exposure to some carcinogens, but the hypotheses presented have not yet been vigorously tested in man. Exposure to carbon monoxide is detrimental to the myocardium, especially in patients with ischémie heart disease, but there are no reliable data on elevated cardiac mortality due to carbon monoxide exposure in industrial populations. A few studies have reported arrhythmias or sudden deaths among workers exposed to solvents and organic nitrates. The effects of lead and cadmium upon human blood pressure have remained controversial, although the bulk of controlled epidemiologic studies suggests that they, if at all existent, are not strong.</abstract><cop>Finland</cop><pub>Scandinavian Journal of Work, Environment & Health</pub><pmid>6398910</pmid><doi>10.5271/sjweh.2316</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Arrhythmias, Cardiac - chemically induced Arsenic - toxicity Arteriosclerosis - chemically induced Atherosclerosis Blood pressure Cadmium Cadmium - toxicity Carbon Disulfide - toxicity Carbon monoxide Carbon Monoxide - toxicity Cardiomyopathies - chemically induced Chemical hazards Cobalt - toxicity Coronary Disease - chemically induced Disulfides Heart diseases Humans Hydrocarbons, Halogenated - toxicity Hypertension Hypertension - chemically induced Lead Lead - toxicity Metals - toxicity Mortality Nitrates - toxicity Occupational Diseases - chemically induced Pesticides - toxicity Polycyclic Compounds - toxicity Risk Solvents - toxicity |
title | Chemical Exposures at Work and Cardiovascular Morbidity Atherosclerosis, Ischemic Heart Disease, Hypertension, Cardiomyopathy and Arrhythmias |
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