The Effects of a Novel Botanical Agent on Lipopolysaccharide‐Induced Alveolar Bone Loss in Rats

Background: The development of host‐modulatory agents with low risk of adverse effects has been needed to treat periodontitis, a chronic inflammatory disease. A botanical mixture of extracts from two natural substances, Panax notoginseng and Rehmannia glutinosa Libosch, was developed as a novel bota...

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Veröffentlicht in:	Journal of periodontology (1970) 2013-08, Vol.84 (8), p.1221-1229
Hauptverfasser:	Lee, Bo‐Ah, Lee, Hwa‐Sun, Jung, Young‐Suk, Kim, Se‐Won, Lee, Yong‐Wook, Chang, Sun‐Hwa, Chung, Hyun‐Ju, Kim, Ok‐Su, Kim, Young‐Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar Bone Loss - prevention & control Alveolar Process - drug effects Animals Anti-Inflammatory Agents - therapeutic use Anti-Inflammatory Agents - toxicity Anti‐inflammatory agents Cell Culture Techniques Cell Line, Tumor Connective Tissue - drug effects cytokines Cytokines - drug effects Dentistry Disease Models, Animal Dose-Response Relationship, Drug Drugs, Chinese Herbal - therapeutic use Drugs, Chinese Herbal - toxicity Escherichia coli Fibroblasts - drug effects Gingiva - cytology Gingiva - drug effects host modulation therapy Humans Interleukin-6 - analysis Lipopolysaccharides - adverse effects Male Matrix Metalloproteinase 9 - drug effects Monocytes - drug effects Monocytes - immunology Periodontal Ligament - drug effects periodontitis Phytotherapy - methods Plant Extracts - therapeutic use Plant Extracts - toxicity Random Allocation Rats Rats, Sprague-Dawley Rehmannia Tumor Necrosis Factor-alpha - drug effects
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