Restrictive guideline reduces platelet count thresholds for transfusions in very low birth weight preterm infants
Background and Objectives Platelet transfusions are performed almost entirely according to expert experience. This study assessed the effectiveness of a restrictive guideline to reduce platelet transfusions in preterm infants. Methods A retrospective cohort of preterm infants with a birth weight o...
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| Veröffentlicht in: | Vox sanguinis 2013-04, Vol.104 (3), p.207-213 |
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| container_title | Vox sanguinis |
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| creator | Borges, J. P. G. dos Santos, A. M. N. da Cunha, D. H. F. Mimica, A. F. M. A. Guinsburg, R. Kopelman, B. I. |
| description | Background and Objectives Platelet transfusions are performed almost entirely according to expert experience. This study assessed the effectiveness of a restrictive guideline to reduce platelet transfusions in preterm infants.
Methods A retrospective cohort of preterm infants with a birth weight of |
| doi_str_mv | 10.1111/j.1423-0410.2012.01658.x |
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Methods A retrospective cohort of preterm infants with a birth weight of <1500 g had been born in 2 periods. In Period 1, a transfusion was indicated for a platelet count of <50 000/ml in clinically stable neonates or <100 000/ml in bleeding or clinically unstable infants. In Period 2, the indications were restricted to <25 000/ml in clinically stable neonates, or <50 000/ml in newborns who were either on mechanical ventilation, subject to imminent invasive procedures, within 72 h following a seizure, or extremely premature and <7 days old. A count of <100 000/ml was indicated for bleeding or major surgery.
Results Periods 1 and 2 comprised 121 and 134 neonates, respectively. The rates of ventricular haemorrhage and intrahospital death were similar in both periods. The percentage of transfused infants, the odds of receiving a platelet transfusion, the mean platelet count before transfusion and the percentage of transfusions with a platelet count >50,000/ml were greater in Period 1. Among thrombocytopenic neonates, the percentage of transfused neonates and the number of transfusions were similar in both groups.
Conclusion The restrictive guideline for platelet transfusions reduced the platelet count thresholds for neonatal transfusions without increasing the rate of ventricular haemorrhage.]]></description><identifier>ISSN: 0042-9007</identifier><identifier>EISSN: 1423-0410</identifier><identifier>DOI: 10.1111/j.1423-0410.2012.01658.x</identifier><identifier>PMID: 23046429</identifier><identifier>CODEN: VOSAAD</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Blood Platelets ; Blood transfusions ; Body Weight ; Female ; guideline ; Humans ; infant ; Infant, Newborn ; Infant, Very Low Birth Weight ; Intensive Care, Neonatal - organization & administration ; Male ; Neonatal care ; neonatal intensive care unit ; Pilot Projects ; Platelet Count - standards ; platelet transfusion ; Platelet Transfusion - methods ; Platelet Transfusion - standards ; Practice Guidelines as Topic ; Premature birth ; Respiration, Artificial ; Retrospective Studies ; Seizures - therapy ; thrombocytopenia ; Time Factors ; very low birth weight</subject><ispartof>Vox sanguinis, 2013-04, Vol.104 (3), p.207-213</ispartof><rights>2012 The Author(s). Vox Sanguinis © 2012 International Society of Blood Transfusion</rights><rights>2012 The Author(s). Vox Sanguinis © 2012 International Society of Blood Transfusion.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5018-209650f6eb75f6234af574eab74a09d5e945a35a8bb0606503905e58da70f1593</citedby><cites>FETCH-LOGICAL-c5018-209650f6eb75f6234af574eab74a09d5e945a35a8bb0606503905e58da70f1593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1423-0410.2012.01658.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1423-0410.2012.01658.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23046429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borges, J. P. G.</creatorcontrib><creatorcontrib>dos Santos, A. M. N.</creatorcontrib><creatorcontrib>da Cunha, D. H. F.</creatorcontrib><creatorcontrib>Mimica, A. F. M. A.</creatorcontrib><creatorcontrib>Guinsburg, R.</creatorcontrib><creatorcontrib>Kopelman, B. I.</creatorcontrib><title>Restrictive guideline reduces platelet count thresholds for transfusions in very low birth weight preterm infants</title><title>Vox sanguinis</title><addtitle>Vox Sang</addtitle><description><![CDATA[Background and Objectives Platelet transfusions are performed almost entirely according to expert experience. This study assessed the effectiveness of a restrictive guideline to reduce platelet transfusions in preterm infants.
Methods A retrospective cohort of preterm infants with a birth weight of <1500 g had been born in 2 periods. In Period 1, a transfusion was indicated for a platelet count of <50 000/ml in clinically stable neonates or <100 000/ml in bleeding or clinically unstable infants. In Period 2, the indications were restricted to <25 000/ml in clinically stable neonates, or <50 000/ml in newborns who were either on mechanical ventilation, subject to imminent invasive procedures, within 72 h following a seizure, or extremely premature and <7 days old. A count of <100 000/ml was indicated for bleeding or major surgery.
Results Periods 1 and 2 comprised 121 and 134 neonates, respectively. The rates of ventricular haemorrhage and intrahospital death were similar in both periods. The percentage of transfused infants, the odds of receiving a platelet transfusion, the mean platelet count before transfusion and the percentage of transfusions with a platelet count >50,000/ml were greater in Period 1. Among thrombocytopenic neonates, the percentage of transfused neonates and the number of transfusions were similar in both groups.
Conclusion The restrictive guideline for platelet transfusions reduced the platelet count thresholds for neonatal transfusions without increasing the rate of ventricular haemorrhage.]]></description><subject>Blood Platelets</subject><subject>Blood transfusions</subject><subject>Body Weight</subject><subject>Female</subject><subject>guideline</subject><subject>Humans</subject><subject>infant</subject><subject>Infant, Newborn</subject><subject>Infant, Very Low Birth Weight</subject><subject>Intensive Care, Neonatal - organization & administration</subject><subject>Male</subject><subject>Neonatal care</subject><subject>neonatal intensive care unit</subject><subject>Pilot Projects</subject><subject>Platelet Count - standards</subject><subject>platelet transfusion</subject><subject>Platelet Transfusion - methods</subject><subject>Platelet Transfusion - standards</subject><subject>Practice Guidelines as Topic</subject><subject>Premature birth</subject><subject>Respiration, Artificial</subject><subject>Retrospective Studies</subject><subject>Seizures - therapy</subject><subject>thrombocytopenia</subject><subject>Time Factors</subject><subject>very low birth weight</subject><issn>0042-9007</issn><issn>1423-0410</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v0zAYhy0EYmXwFZAlLlzSvf6b5MABKlZAE5MQDG6Wk7xZXdKks521_fY46-iBE77Ysp_ntf3-CKEM5iyNi_WcSS4ykGmDA-NzYFoV8_0TMjsdPCUzAMmzEiA_Iy9CWANAwQv1nJxxAVJLXs7I3TcM0bs6unukt6NrsHM9Uo_NWGOg285G7DDSehj7SOPKY1gNXRNoO3gave1DOwY39IG6nt6jP9Bu2NHK-biiO3S3q0i3HiP6TQJa28fwkjxrbRfw1eN8Tn5cfvy--JRdXS8_L95fZbUCVmQcSq2g1VjlqtVcSNuqXKKtcmmhbBSWUlmhbFFVoCGhogSFqmhsDi1TpTgnb491t364G9MvzcaFGrvO9jiMwTDJNEihYELf_IOuh9H36XWGCVYorRlniSqOVO2HEDy2ZuvdxvqDYWCmWMzaTN03U_fNFIt5iMXsk_r68YKx2mBzEv_mkIB3R2DnOjz8d2Fzc_1rWiU_O_ouRNyffOt_G52LXJmfX5fmUn64-SKXuVmIPz2uqyA</recordid><startdate>201304</startdate><enddate>201304</enddate><creator>Borges, J. P. G.</creator><creator>dos Santos, A. M. N.</creator><creator>da Cunha, D. H. F.</creator><creator>Mimica, A. F. M. A.</creator><creator>Guinsburg, R.</creator><creator>Kopelman, B. I.</creator><general>Blackwell Publishing Ltd</general><general>S. Karger AG</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201304</creationdate><title>Restrictive guideline reduces platelet count thresholds for transfusions in very low birth weight preterm infants</title><author>Borges, J. P. G. ; dos Santos, A. M. N. ; da Cunha, D. H. F. ; Mimica, A. F. M. A. ; Guinsburg, R. ; Kopelman, B. I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5018-209650f6eb75f6234af574eab74a09d5e945a35a8bb0606503905e58da70f1593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Blood Platelets</topic><topic>Blood transfusions</topic><topic>Body Weight</topic><topic>Female</topic><topic>guideline</topic><topic>Humans</topic><topic>infant</topic><topic>Infant, Newborn</topic><topic>Infant, Very Low Birth Weight</topic><topic>Intensive Care, Neonatal - organization & administration</topic><topic>Male</topic><topic>Neonatal care</topic><topic>neonatal intensive care unit</topic><topic>Pilot Projects</topic><topic>Platelet Count - standards</topic><topic>platelet transfusion</topic><topic>Platelet Transfusion - methods</topic><topic>Platelet Transfusion - standards</topic><topic>Practice Guidelines as Topic</topic><topic>Premature birth</topic><topic>Respiration, Artificial</topic><topic>Retrospective Studies</topic><topic>Seizures - therapy</topic><topic>thrombocytopenia</topic><topic>Time Factors</topic><topic>very low birth weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borges, J. P. G.</creatorcontrib><creatorcontrib>dos Santos, A. M. N.</creatorcontrib><creatorcontrib>da Cunha, D. H. F.</creatorcontrib><creatorcontrib>Mimica, A. F. M. A.</creatorcontrib><creatorcontrib>Guinsburg, R.</creatorcontrib><creatorcontrib>Kopelman, B. I.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Vox sanguinis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borges, J. P. G.</au><au>dos Santos, A. M. N.</au><au>da Cunha, D. H. F.</au><au>Mimica, A. F. M. A.</au><au>Guinsburg, R.</au><au>Kopelman, B. I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Restrictive guideline reduces platelet count thresholds for transfusions in very low birth weight preterm infants</atitle><jtitle>Vox sanguinis</jtitle><addtitle>Vox Sang</addtitle><date>2013-04</date><risdate>2013</risdate><volume>104</volume><issue>3</issue><spage>207</spage><epage>213</epage><pages>207-213</pages><issn>0042-9007</issn><eissn>1423-0410</eissn><coden>VOSAAD</coden><abstract><![CDATA[Background and Objectives Platelet transfusions are performed almost entirely according to expert experience. This study assessed the effectiveness of a restrictive guideline to reduce platelet transfusions in preterm infants.
Methods A retrospective cohort of preterm infants with a birth weight of <1500 g had been born in 2 periods. In Period 1, a transfusion was indicated for a platelet count of <50 000/ml in clinically stable neonates or <100 000/ml in bleeding or clinically unstable infants. In Period 2, the indications were restricted to <25 000/ml in clinically stable neonates, or <50 000/ml in newborns who were either on mechanical ventilation, subject to imminent invasive procedures, within 72 h following a seizure, or extremely premature and <7 days old. A count of <100 000/ml was indicated for bleeding or major surgery.
Results Periods 1 and 2 comprised 121 and 134 neonates, respectively. The rates of ventricular haemorrhage and intrahospital death were similar in both periods. The percentage of transfused infants, the odds of receiving a platelet transfusion, the mean platelet count before transfusion and the percentage of transfusions with a platelet count >50,000/ml were greater in Period 1. Among thrombocytopenic neonates, the percentage of transfused neonates and the number of transfusions were similar in both groups.
Conclusion The restrictive guideline for platelet transfusions reduced the platelet count thresholds for neonatal transfusions without increasing the rate of ventricular haemorrhage.]]></abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>23046429</pmid><doi>10.1111/j.1423-0410.2012.01658.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Blood Platelets Blood transfusions Body Weight Female guideline Humans infant Infant, Newborn Infant, Very Low Birth Weight Intensive Care, Neonatal - organization & administration Male Neonatal care neonatal intensive care unit Pilot Projects Platelet Count - standards platelet transfusion Platelet Transfusion - methods Platelet Transfusion - standards Practice Guidelines as Topic Premature birth Respiration, Artificial Retrospective Studies Seizures - therapy thrombocytopenia Time Factors very low birth weight |
| title | Restrictive guideline reduces platelet count thresholds for transfusions in very low birth weight preterm infants |
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