Neutrophils contain cholesterol crystals in transfusion-related acute lung injury (TRALI)
Intracellular components of transfusion-related acute lung injury (TRALI) were investigated by transmission electron microscopy. The lungs from 2 fatal TRALI cases and 2 controls, previously studied by scanning electron microscopy, were studied by transmission electron microscopy. Morphologic data b...
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| Veröffentlicht in: | American journal of clinical pathology 2013-08, Vol.140 (2), p.170-176 |
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| container_title | American journal of clinical pathology |
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| creator | Van Ness, Michael Jensen, Hanne Adamson, Grete N Kysar, Patricia E Holland, Paul |
| description | Intracellular components of transfusion-related acute lung injury (TRALI) were investigated by transmission electron microscopy.
The lungs from 2 fatal TRALI cases and 2 controls, previously studied by scanning electron microscopy, were studied by transmission electron microscopy. Morphologic data by light and phase microscopy, along with scanning and transmission electron microscopic observations, were collated.
The 2 fatal TRALI cases exhibited dense laminated material within capillaries and postcapillary venules, similar to material identified within their neutrophils when viewed by transmission electron microscopy. This material polarized light and is presumed to be cholesterol crystals.
The damage to the pulmonary vascular endothelium in TRALI is related to formation of cholesterol crystals originating within neutrophils. |
| doi_str_mv | 10.1309/AJCPGKOJV15AVZNT |
| format | Article |
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The lungs from 2 fatal TRALI cases and 2 controls, previously studied by scanning electron microscopy, were studied by transmission electron microscopy. Morphologic data by light and phase microscopy, along with scanning and transmission electron microscopic observations, were collated.
The 2 fatal TRALI cases exhibited dense laminated material within capillaries and postcapillary venules, similar to material identified within their neutrophils when viewed by transmission electron microscopy. This material polarized light and is presumed to be cholesterol crystals.
The damage to the pulmonary vascular endothelium in TRALI is related to formation of cholesterol crystals originating within neutrophils.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1309/AJCPGKOJV15AVZNT</identifier><identifier>PMID: 23897251</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Acute Lung Injury - blood ; Acute Lung Injury - etiology ; Acute Lung Injury - metabolism ; Adult ; Cholesterol - metabolism ; Humans ; Male ; Neutrophils - metabolism ; Transfusion Reaction</subject><ispartof>American journal of clinical pathology, 2013-08, Vol.140 (2), p.170-176</ispartof><rights>Copyright American Society for Clinical Pathology Aug 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-445e11815713ab3e079b69786f08e146db2d49f7e40fcf299f0393d037052b2a3</citedby><cites>FETCH-LOGICAL-c369t-445e11815713ab3e079b69786f08e146db2d49f7e40fcf299f0393d037052b2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23897251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Ness, Michael</creatorcontrib><creatorcontrib>Jensen, Hanne</creatorcontrib><creatorcontrib>Adamson, Grete N</creatorcontrib><creatorcontrib>Kysar, Patricia E</creatorcontrib><creatorcontrib>Holland, Paul</creatorcontrib><title>Neutrophils contain cholesterol crystals in transfusion-related acute lung injury (TRALI)</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>Intracellular components of transfusion-related acute lung injury (TRALI) were investigated by transmission electron microscopy.
The lungs from 2 fatal TRALI cases and 2 controls, previously studied by scanning electron microscopy, were studied by transmission electron microscopy. Morphologic data by light and phase microscopy, along with scanning and transmission electron microscopic observations, were collated.
The 2 fatal TRALI cases exhibited dense laminated material within capillaries and postcapillary venules, similar to material identified within their neutrophils when viewed by transmission electron microscopy. This material polarized light and is presumed to be cholesterol crystals.
The damage to the pulmonary vascular endothelium in TRALI is related to formation of cholesterol crystals originating within neutrophils.</description><subject>Acute Lung Injury - blood</subject><subject>Acute Lung Injury - etiology</subject><subject>Acute Lung Injury - metabolism</subject><subject>Adult</subject><subject>Cholesterol - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Neutrophils - metabolism</subject><subject>Transfusion Reaction</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkM1PwkAUxDdGI4jePZkmXvBQffvRbvdIiCJIwBgk0UuzbbdSUrq42z3w37sE9ODpJfN-M5kMQtcY7jEF8TCYDF9HL_PJEkeD5edscYK6WDAack7IKeoCAAkF5rSDLqxdA2CSADtHHUITwUmEu-hjplxr9HZV1TbIddPKqgnyla6VbZXRdZCbnW2lf3q9NbKxpbOVbkKjatmqIpC5a1VQu-bLE2tndkF_8TaYju8u0VnpferqeHvo_elxMXwOp_PReDiYhjmNRRsyFimMExxxTGVGFXCRxYIncQmJwiwuMlIwUXLFoMxLIkQJVNACKIeIZETSHuofcrdGfztfO91UNld1LRulnU0xwzEwIijz6O0_dK2daXy7PSWAMIFjT8GByo221qgy3ZpqI80uxZDuZ0__z-4tN8dgl21U8Wf43Zn-ANehfg4</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Van Ness, Michael</creator><creator>Jensen, Hanne</creator><creator>Adamson, Grete N</creator><creator>Kysar, Patricia E</creator><creator>Holland, Paul</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201308</creationdate><title>Neutrophils contain cholesterol crystals in transfusion-related acute lung injury (TRALI)</title><author>Van Ness, Michael ; 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The lungs from 2 fatal TRALI cases and 2 controls, previously studied by scanning electron microscopy, were studied by transmission electron microscopy. Morphologic data by light and phase microscopy, along with scanning and transmission electron microscopic observations, were collated.
The 2 fatal TRALI cases exhibited dense laminated material within capillaries and postcapillary venules, similar to material identified within their neutrophils when viewed by transmission electron microscopy. This material polarized light and is presumed to be cholesterol crystals.
The damage to the pulmonary vascular endothelium in TRALI is related to formation of cholesterol crystals originating within neutrophils.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>23897251</pmid><doi>10.1309/AJCPGKOJV15AVZNT</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0002-9173 |
| ispartof | American journal of clinical pathology, 2013-08, Vol.140 (2), p.170-176 |
| issn | 0002-9173 1943-7722 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Acute Lung Injury - blood Acute Lung Injury - etiology Acute Lung Injury - metabolism Adult Cholesterol - metabolism Humans Male Neutrophils - metabolism Transfusion Reaction |
| title | Neutrophils contain cholesterol crystals in transfusion-related acute lung injury (TRALI) |
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