The incidence of type 2 diabetes in the United Kingdom from 1991 to 2010
Aims To characterize the incidence of type 2 diabetes in the UK over the previous 20 years; and determine if there has been an increase in people aged 40 years or less at diagnosis. Methods For this retrospective cohort study, patients newly diagnosed with type 2 diabetes between 1991 and 2010 were...
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| Veröffentlicht in: | Diabetes, obesity & metabolism obesity & metabolism, 2013-09, Vol.15 (9), p.844-852 |
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| creator | Holden, S. E. Barnett, A. H. Peters, J. R. Jenkins-Jones, S. Poole, C. D. Morgan, C. L. Currie, C. J. |
| description | Aims
To characterize the incidence of type 2 diabetes in the UK over the previous 20 years; and determine if there has been an increase in people aged 40 years or less at diagnosis.
Methods
For this retrospective cohort study, patients newly diagnosed with type 2 diabetes between 1991 and 2010 were identified from the UK Clinical Practice Research Datalink (CPRD). Patient data were grouped into 5‐year intervals by year of diagnosis and age at diagnosis. A standardized incidence ratio (SIR) was determined (1991–1995 = 100). The percentage of newly diagnosed patients for each age group and aged ≤40 years was calculated for each 5‐year calendar period. The incidence rate by age and 5‐year calendar period was also determined.
Results
In 2010, the crude incidence rate of type 2 diabetes was 515 per 100,000 population. The overall SIR increased to 158 (95% CI 157–160, p |
| doi_str_mv | 10.1111/dom.12123 |
| format | Article |
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To characterize the incidence of type 2 diabetes in the UK over the previous 20 years; and determine if there has been an increase in people aged 40 years or less at diagnosis.
Methods
For this retrospective cohort study, patients newly diagnosed with type 2 diabetes between 1991 and 2010 were identified from the UK Clinical Practice Research Datalink (CPRD). Patient data were grouped into 5‐year intervals by year of diagnosis and age at diagnosis. A standardized incidence ratio (SIR) was determined (1991–1995 = 100). The percentage of newly diagnosed patients for each age group and aged ≤40 years was calculated for each 5‐year calendar period. The incidence rate by age and 5‐year calendar period was also determined.
Results
In 2010, the crude incidence rate of type 2 diabetes was 515 per 100,000 population. The overall SIR increased to 158 (95% CI 157–160, p < 0.001), 237 (235–238, p < 0.001) and 275 (273–276, p < 0.001) for 1996–2000, 2001–2005 and 2006–2010, respectively. For those ≤40, the respective values were 217 (209–226, p < 0.001), 327 (320–335, p < 0.001) and 598 (589–608, p < 0.001). An increase in incidence occurred with increasing 5‐year calendar period. The incidence of type 2 diabetes was higher for males after the age of 40 and higher for females aged ≤40. The percentage of patients aged ≤40 years at diagnosis increased with each increasing 5‐year calendar period (5.9, 8.4, 8.5 and 12.4%, respectively).
Conclusions
There was a significant increase in the incidence of diagnosed type 2 diabetes between 1991 and 2010 and the proportion of people diagnosed at a relatively early age has increased markedly.]]></description><identifier>ISSN: 1462-8902</identifier><identifier>EISSN: 1463-1326</identifier><identifier>DOI: 10.1111/dom.12123</identifier><identifier>PMID: 23675742</identifier><identifier>CODEN: DOMEF6</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Age ; Age of Onset ; Blood Glucose - metabolism ; Body Mass Index ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - prevention & control ; Diagnosis ; Early Diagnosis ; epidemiology ; Female ; Glycated Hemoglobin A - metabolism ; Health risk assessment ; Humans ; Incidence ; Male ; Registries ; Retrospective Studies ; Smoking - epidemiology ; United Kingdom - epidemiology</subject><ispartof>Diabetes, obesity & metabolism, 2013-09, Vol.15 (9), p.844-852</ispartof><rights>2013 Blackwell Publishing Ltd</rights><rights>2013 Blackwell Publishing Ltd.</rights><rights>2013 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4003-692a7408474a6f8c621a8be8bf33fde1717360f96951b4787c46ae33944384143</citedby><cites>FETCH-LOGICAL-c4003-692a7408474a6f8c621a8be8bf33fde1717360f96951b4787c46ae33944384143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdom.12123$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdom.12123$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23675742$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holden, S. E.</creatorcontrib><creatorcontrib>Barnett, A. H.</creatorcontrib><creatorcontrib>Peters, J. R.</creatorcontrib><creatorcontrib>Jenkins-Jones, S.</creatorcontrib><creatorcontrib>Poole, C. D.</creatorcontrib><creatorcontrib>Morgan, C. L.</creatorcontrib><creatorcontrib>Currie, C. J.</creatorcontrib><title>The incidence of type 2 diabetes in the United Kingdom from 1991 to 2010</title><title>Diabetes, obesity & metabolism</title><addtitle>Diabetes Obes Metab</addtitle><description><![CDATA[Aims
To characterize the incidence of type 2 diabetes in the UK over the previous 20 years; and determine if there has been an increase in people aged 40 years or less at diagnosis.
Methods
For this retrospective cohort study, patients newly diagnosed with type 2 diabetes between 1991 and 2010 were identified from the UK Clinical Practice Research Datalink (CPRD). Patient data were grouped into 5‐year intervals by year of diagnosis and age at diagnosis. A standardized incidence ratio (SIR) was determined (1991–1995 = 100). The percentage of newly diagnosed patients for each age group and aged ≤40 years was calculated for each 5‐year calendar period. The incidence rate by age and 5‐year calendar period was also determined.
Results
In 2010, the crude incidence rate of type 2 diabetes was 515 per 100,000 population. The overall SIR increased to 158 (95% CI 157–160, p < 0.001), 237 (235–238, p < 0.001) and 275 (273–276, p < 0.001) for 1996–2000, 2001–2005 and 2006–2010, respectively. For those ≤40, the respective values were 217 (209–226, p < 0.001), 327 (320–335, p < 0.001) and 598 (589–608, p < 0.001). An increase in incidence occurred with increasing 5‐year calendar period. The incidence of type 2 diabetes was higher for males after the age of 40 and higher for females aged ≤40. The percentage of patients aged ≤40 years at diagnosis increased with each increasing 5‐year calendar period (5.9, 8.4, 8.5 and 12.4%, respectively).
Conclusions
There was a significant increase in the incidence of diagnosed type 2 diabetes between 1991 and 2010 and the proportion of people diagnosed at a relatively early age has increased markedly.]]></description><subject>Adult</subject><subject>Age</subject><subject>Age of Onset</subject><subject>Blood Glucose - metabolism</subject><subject>Body Mass Index</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - prevention & control</subject><subject>Diagnosis</subject><subject>Early Diagnosis</subject><subject>epidemiology</subject><subject>Female</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Smoking - epidemiology</subject><subject>United Kingdom - epidemiology</subject><issn>1462-8902</issn><issn>1463-1326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi1ERUvhwAsgS1zgkNbjmdjJES2wrdpSCbbq0XKSCbhskm2cFezb8Cw8Wd1u2wMS-GJL_ubz7xkhXoE6gLQOm6E7AA0an4g9IIMZoDZP7846K0qld8XzGK-UUoSFfSZ2NRqbW9J74njxnWXo69BwX7McWjltViy1bIKveOKYLuWUmIs-TNzIk9B_S8_Jdhy6P7-hLEFOg9QK1Aux0_pl5Jf3-764-PRxMTvKTs_nx7P3p1lNSmFmSu0tqYIsedMWtdHgi4qLqkVsGwYLFo1qS1PmUJEtbE3GM2JJKTsB4b54u_WuxuF6zXFyXYg1L5e-52EdHRDkBpTGW_TNX-jVsB77lM6hykuCFAT_RyVX-qKmXCXq3ZaqxyHGkVu3GkPnx40D5W6n4FJb3N0UEvv63riuOm4eyYe2J-BwC_wMS9782-Q-nJ89KLNtRYgT_3qs8OMPZyza3F1-nrsv86MFXdLMfcUbZFCaGQ</recordid><startdate>201309</startdate><enddate>201309</enddate><creator>Holden, S. E.</creator><creator>Barnett, A. H.</creator><creator>Peters, J. R.</creator><creator>Jenkins-Jones, S.</creator><creator>Poole, C. D.</creator><creator>Morgan, C. L.</creator><creator>Currie, C. J.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201309</creationdate><title>The incidence of type 2 diabetes in the United Kingdom from 1991 to 2010</title><author>Holden, S. E. ; Barnett, A. H. ; Peters, J. R. ; Jenkins-Jones, S. ; Poole, C. D. ; Morgan, C. L. ; Currie, C. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4003-692a7408474a6f8c621a8be8bf33fde1717360f96951b4787c46ae33944384143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age of Onset</topic><topic>Blood Glucose - metabolism</topic><topic>Body Mass Index</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - prevention & control</topic><topic>Diagnosis</topic><topic>Early Diagnosis</topic><topic>epidemiology</topic><topic>Female</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Smoking - epidemiology</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holden, S. E.</creatorcontrib><creatorcontrib>Barnett, A. H.</creatorcontrib><creatorcontrib>Peters, J. R.</creatorcontrib><creatorcontrib>Jenkins-Jones, S.</creatorcontrib><creatorcontrib>Poole, C. D.</creatorcontrib><creatorcontrib>Morgan, C. L.</creatorcontrib><creatorcontrib>Currie, C. J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes, obesity & metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holden, S. E.</au><au>Barnett, A. H.</au><au>Peters, J. R.</au><au>Jenkins-Jones, S.</au><au>Poole, C. D.</au><au>Morgan, C. L.</au><au>Currie, C. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The incidence of type 2 diabetes in the United Kingdom from 1991 to 2010</atitle><jtitle>Diabetes, obesity & metabolism</jtitle><addtitle>Diabetes Obes Metab</addtitle><date>2013-09</date><risdate>2013</risdate><volume>15</volume><issue>9</issue><spage>844</spage><epage>852</epage><pages>844-852</pages><issn>1462-8902</issn><eissn>1463-1326</eissn><coden>DOMEF6</coden><abstract><![CDATA[Aims
To characterize the incidence of type 2 diabetes in the UK over the previous 20 years; and determine if there has been an increase in people aged 40 years or less at diagnosis.
Methods
For this retrospective cohort study, patients newly diagnosed with type 2 diabetes between 1991 and 2010 were identified from the UK Clinical Practice Research Datalink (CPRD). Patient data were grouped into 5‐year intervals by year of diagnosis and age at diagnosis. A standardized incidence ratio (SIR) was determined (1991–1995 = 100). The percentage of newly diagnosed patients for each age group and aged ≤40 years was calculated for each 5‐year calendar period. The incidence rate by age and 5‐year calendar period was also determined.
Results
In 2010, the crude incidence rate of type 2 diabetes was 515 per 100,000 population. The overall SIR increased to 158 (95% CI 157–160, p < 0.001), 237 (235–238, p < 0.001) and 275 (273–276, p < 0.001) for 1996–2000, 2001–2005 and 2006–2010, respectively. For those ≤40, the respective values were 217 (209–226, p < 0.001), 327 (320–335, p < 0.001) and 598 (589–608, p < 0.001). An increase in incidence occurred with increasing 5‐year calendar period. The incidence of type 2 diabetes was higher for males after the age of 40 and higher for females aged ≤40. The percentage of patients aged ≤40 years at diagnosis increased with each increasing 5‐year calendar period (5.9, 8.4, 8.5 and 12.4%, respectively).
Conclusions
There was a significant increase in the incidence of diagnosed type 2 diabetes between 1991 and 2010 and the proportion of people diagnosed at a relatively early age has increased markedly.]]></abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>23675742</pmid><doi>10.1111/dom.12123</doi><tpages>9</tpages></addata></record> |
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| ispartof | Diabetes, obesity & metabolism, 2013-09, Vol.15 (9), p.844-852 |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Age Age of Onset Blood Glucose - metabolism Body Mass Index Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - prevention & control Diagnosis Early Diagnosis epidemiology Female Glycated Hemoglobin A - metabolism Health risk assessment Humans Incidence Male Registries Retrospective Studies Smoking - epidemiology United Kingdom - epidemiology |
| title | The incidence of type 2 diabetes in the United Kingdom from 1991 to 2010 |
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