Current clinical status on the preventive effects of cranberry consumption against urinary tract infections
Abstract Urinary tract infections (UTIs) represent a common and quite costly medical problem, primarily affecting the female population which may be due to a shorter urethra. The bacterium Escherichia coli are mainly responsible for most uncomplicated UTIs. Cranberry antibacterial effects have widel...
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| Veröffentlicht in: | Nutrition research (New York, N.Y.) N.Y.), 2013-08, Vol.33 (8), p.595-607 |
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| creator | Vasileiou, Ioanna Katsargyris, Athanasios Theocharis, Stamatios Giaginis, Constantinos |
| description | Abstract Urinary tract infections (UTIs) represent a common and quite costly medical problem, primarily affecting the female population which may be due to a shorter urethra. The bacterium Escherichia coli are mainly responsible for most uncomplicated UTIs. Cranberry antibacterial effects have widely been studied in vitro, and laboratory and clinical studies have also been performed to elucidate the mechanisms of cranberry actions and the clinical benefits of cranberry consumption against UTIs. The present review aimed to summarize the proposed mechanisms of cranberry actions against UTIs and the clinical trials that evaluated the efficacy of supplementing cranberry products in different subpopulations. Taking into consideration the existing data, cranberry consumption may prevent bacterial adherence to uroepithelial cells which reduces the development of UTI. Cranberry consumption could also decreasing UTI related symptoms by suppressing inflammatory cascades as an immunologic response to bacteria invasion. The existing clinical trials suggest that the beneficial effects of cranberry against UTIs seem to be prophylactic by preventing the development of infections; however, they exert low effectiveness in populations at increased risk for contracting UTIs. Additional well-designed, double-blind, placebo-controlled clinical trials that use standardized cranberry products are strongly justified in order to determine the efficiency of cranberry on the prevention of UTIs in susceptible populations. |
| doi_str_mv | 10.1016/j.nutres.2013.05.018 |
| format | Article |
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The bacterium Escherichia coli are mainly responsible for most uncomplicated UTIs. Cranberry antibacterial effects have widely been studied in vitro, and laboratory and clinical studies have also been performed to elucidate the mechanisms of cranberry actions and the clinical benefits of cranberry consumption against UTIs. The present review aimed to summarize the proposed mechanisms of cranberry actions against UTIs and the clinical trials that evaluated the efficacy of supplementing cranberry products in different subpopulations. Taking into consideration the existing data, cranberry consumption may prevent bacterial adherence to uroepithelial cells which reduces the development of UTI. Cranberry consumption could also decreasing UTI related symptoms by suppressing inflammatory cascades as an immunologic response to bacteria invasion. The existing clinical trials suggest that the beneficial effects of cranberry against UTIs seem to be prophylactic by preventing the development of infections; however, they exert low effectiveness in populations at increased risk for contracting UTIs. Additional well-designed, double-blind, placebo-controlled clinical trials that use standardized cranberry products are strongly justified in order to determine the efficiency of cranberry on the prevention of UTIs in susceptible populations.</description><identifier>ISSN: 0271-5317</identifier><identifier>EISSN: 1879-0739</identifier><identifier>DOI: 10.1016/j.nutres.2013.05.018</identifier><identifier>PMID: 23890348</identifier><identifier>CODEN: NTRSDC</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Antimicrobial activity ; Bacterial Adhesion - drug effects ; Bacterial diseases ; Bacterial diseases of the urinary system ; Biological and medical sciences ; Clinical trials ; Cranberry ; Escherichia coli ; Feeding. Feeding behavior ; Fruit ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Human bacterial diseases ; Humans ; Immune response ; Infectious diseases ; Inflammatory reaction ; Medical sciences ; Nephrology. Urinary tract diseases ; Phytotherapy ; Plant Preparations - pharmacology ; Plant Preparations - therapeutic use ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract infections ; Urinary Tract Infections - microbiology ; Urinary Tract Infections - prevention & control ; Urinary tract. Prostate gland ; Urothelium - drug effects ; Urothelium - microbiology ; Vaccinium macrocarpon ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Nutrition research (New York, N.Y.), 2013-08, Vol.33 (8), p.595-607</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-185af5024a2b9dad5be924dd0eabd74ccdbedf243ec6c97394ca29c93c145e2f3</citedby><cites>FETCH-LOGICAL-c447t-185af5024a2b9dad5be924dd0eabd74ccdbedf243ec6c97394ca29c93c145e2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0271531713001280$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27604535$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23890348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vasileiou, Ioanna</creatorcontrib><creatorcontrib>Katsargyris, Athanasios</creatorcontrib><creatorcontrib>Theocharis, Stamatios</creatorcontrib><creatorcontrib>Giaginis, Constantinos</creatorcontrib><title>Current clinical status on the preventive effects of cranberry consumption against urinary tract infections</title><title>Nutrition research (New York, N.Y.)</title><addtitle>Nutr Res</addtitle><description>Abstract Urinary tract infections (UTIs) represent a common and quite costly medical problem, primarily affecting the female population which may be due to a shorter urethra. The bacterium Escherichia coli are mainly responsible for most uncomplicated UTIs. Cranberry antibacterial effects have widely been studied in vitro, and laboratory and clinical studies have also been performed to elucidate the mechanisms of cranberry actions and the clinical benefits of cranberry consumption against UTIs. The present review aimed to summarize the proposed mechanisms of cranberry actions against UTIs and the clinical trials that evaluated the efficacy of supplementing cranberry products in different subpopulations. Taking into consideration the existing data, cranberry consumption may prevent bacterial adherence to uroepithelial cells which reduces the development of UTI. Cranberry consumption could also decreasing UTI related symptoms by suppressing inflammatory cascades as an immunologic response to bacteria invasion. The existing clinical trials suggest that the beneficial effects of cranberry against UTIs seem to be prophylactic by preventing the development of infections; however, they exert low effectiveness in populations at increased risk for contracting UTIs. Additional well-designed, double-blind, placebo-controlled clinical trials that use standardized cranberry products are strongly justified in order to determine the efficiency of cranberry on the prevention of UTIs in susceptible populations.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antimicrobial activity</subject><subject>Bacterial Adhesion - drug effects</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the urinary system</subject><subject>Biological and medical sciences</subject><subject>Clinical trials</subject><subject>Cranberry</subject><subject>Escherichia coli</subject><subject>Feeding. Feeding behavior</subject><subject>Fruit</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology and Hepatology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Immune response</subject><subject>Infectious diseases</subject><subject>Inflammatory reaction</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Phytotherapy</subject><subject>Plant Preparations - pharmacology</subject><subject>Plant Preparations - therapeutic use</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract infections</subject><subject>Urinary Tract Infections - microbiology</subject><subject>Urinary Tract Infections - prevention & control</subject><subject>Urinary tract. Prostate gland</subject><subject>Urothelium - drug effects</subject><subject>Urothelium - microbiology</subject><subject>Vaccinium macrocarpon</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0271-5317</issn><issn>1879-0739</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2LFDEQhoMo7rj6D0RyEbx0m8_p7osgw_oBCx7Uc0gn1ZrZnvSYSgb235tmZhW8eMrhfapSeVKEvOSs5Yxv3-7bWHICbAXjsmW6Zbx_RDa874aGdXJ4TDZMdLzRkndX5BninjHecSmfkish-4FJ1W_I3a6kBDFTN4cYnJ0pZpsL0iXS_BPoMcGpxuEEFKYJXK7JRF2ycYSU7qlbIpbDMYfK2x82RMy0pBBtzXKyLtMQ17Ka43PyZLIzwovLeU2-f7j5tvvU3H75-Hn3_rZxSnW54b22k2ZCWTEO3no9wiCU9wzs6DvlnB_BT0JJcFs31JcqZ8XgBum40iAmeU3enPse0_KrAGZzCOhgnm2EpaDhiust6wcpKqrOqEsLYoLJHFM41OENZ2bVbPbmrNmsmg3TpmquZa8uN5TxAP5P0YPXCry-ABar1Kn6cgH_ct2WKS115d6dOag-TgGSQRcgOvAhVWvGL-F_k_zb4OEj7-AecL-UFKtrww0Kw8zXdSXWjeCyboPomfwNhse1qQ</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Vasileiou, Ioanna</creator><creator>Katsargyris, Athanasios</creator><creator>Theocharis, Stamatios</creator><creator>Giaginis, Constantinos</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130801</creationdate><title>Current clinical status on the preventive effects of cranberry consumption against urinary tract infections</title><author>Vasileiou, Ioanna ; Katsargyris, Athanasios ; Theocharis, Stamatios ; Giaginis, Constantinos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-185af5024a2b9dad5be924dd0eabd74ccdbedf243ec6c97394ca29c93c145e2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Antimicrobial activity</topic><topic>Bacterial Adhesion - drug effects</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the urinary system</topic><topic>Biological and medical sciences</topic><topic>Clinical trials</topic><topic>Cranberry</topic><topic>Escherichia coli</topic><topic>Feeding. Feeding behavior</topic><topic>Fruit</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology and Hepatology</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Immune response</topic><topic>Infectious diseases</topic><topic>Inflammatory reaction</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Phytotherapy</topic><topic>Plant Preparations - pharmacology</topic><topic>Plant Preparations - therapeutic use</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract infections</topic><topic>Urinary Tract Infections - microbiology</topic><topic>Urinary Tract Infections - prevention & control</topic><topic>Urinary tract. Prostate gland</topic><topic>Urothelium - drug effects</topic><topic>Urothelium - microbiology</topic><topic>Vaccinium macrocarpon</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vasileiou, Ioanna</creatorcontrib><creatorcontrib>Katsargyris, Athanasios</creatorcontrib><creatorcontrib>Theocharis, Stamatios</creatorcontrib><creatorcontrib>Giaginis, Constantinos</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition research (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vasileiou, Ioanna</au><au>Katsargyris, Athanasios</au><au>Theocharis, Stamatios</au><au>Giaginis, Constantinos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current clinical status on the preventive effects of cranberry consumption against urinary tract infections</atitle><jtitle>Nutrition research (New York, N.Y.)</jtitle><addtitle>Nutr Res</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>33</volume><issue>8</issue><spage>595</spage><epage>607</epage><pages>595-607</pages><issn>0271-5317</issn><eissn>1879-0739</eissn><coden>NTRSDC</coden><abstract>Abstract Urinary tract infections (UTIs) represent a common and quite costly medical problem, primarily affecting the female population which may be due to a shorter urethra. The bacterium Escherichia coli are mainly responsible for most uncomplicated UTIs. Cranberry antibacterial effects have widely been studied in vitro, and laboratory and clinical studies have also been performed to elucidate the mechanisms of cranberry actions and the clinical benefits of cranberry consumption against UTIs. The present review aimed to summarize the proposed mechanisms of cranberry actions against UTIs and the clinical trials that evaluated the efficacy of supplementing cranberry products in different subpopulations. Taking into consideration the existing data, cranberry consumption may prevent bacterial adherence to uroepithelial cells which reduces the development of UTI. Cranberry consumption could also decreasing UTI related symptoms by suppressing inflammatory cascades as an immunologic response to bacteria invasion. The existing clinical trials suggest that the beneficial effects of cranberry against UTIs seem to be prophylactic by preventing the development of infections; however, they exert low effectiveness in populations at increased risk for contracting UTIs. Additional well-designed, double-blind, placebo-controlled clinical trials that use standardized cranberry products are strongly justified in order to determine the efficiency of cranberry on the prevention of UTIs in susceptible populations.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>23890348</pmid><doi>10.1016/j.nutres.2013.05.018</doi><tpages>13</tpages></addata></record> |
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| ispartof | Nutrition research (New York, N.Y.), 2013-08, Vol.33 (8), p.595-607 |
| issn | 0271-5317 1879-0739 |
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| subjects | Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antimicrobial activity Bacterial Adhesion - drug effects Bacterial diseases Bacterial diseases of the urinary system Biological and medical sciences Clinical trials Cranberry Escherichia coli Feeding. Feeding behavior Fruit Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology Human bacterial diseases Humans Immune response Infectious diseases Inflammatory reaction Medical sciences Nephrology. Urinary tract diseases Phytotherapy Plant Preparations - pharmacology Plant Preparations - therapeutic use Urinary system involvement in other diseases. Miscellaneous Urinary tract infections Urinary Tract Infections - microbiology Urinary Tract Infections - prevention & control Urinary tract. Prostate gland Urothelium - drug effects Urothelium - microbiology Vaccinium macrocarpon Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Current clinical status on the preventive effects of cranberry consumption against urinary tract infections |
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