Comparison of bleomycin-detectable iron and labile plasma iron assays
To the Editor: Non-transferrin-bound iron (NTBI)1 is detected in the plasma of pa- tients with diseases in which the transferrin-binding capacity for iron is exceeded by a massive iron overload, such as in certain forms of thalassemia and hemochroma- tosis, repeated blood transfu- sions, or bone mar...
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| Veröffentlicht in: | Clinical chemistry (Baltimore, Md.) Md.), 2013-08, Vol.59 (8), p.1271-1273 |
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| container_title | Clinical chemistry (Baltimore, Md.) |
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| creator | Itkonen, Outi Vaahtera, Lauri Parkkinen, Jaakko |
| description | To the Editor: Non-transferrin-bound iron (NTBI)1 is detected in the plasma of pa- tients with diseases in which the transferrin-binding capacity for iron is exceeded by a massive iron overload, such as in certain forms of thalassemia and hemochroma- tosis, repeated blood transfu- sions, or bone marrow failure. Excess iron is harmful because it causes oxidative stress, accumu- lates in and damages tissues, and enhances the growth of patho- gens. [...]the measure- ment of NTBI is of clinical im- portance, because NTBI may be used as an indicator of systemic iron overload and iron toxicity (1,2). |
| doi_str_mv | 10.1373/clinchem.2013.205302 |
| format | Article |
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Excess iron is harmful because it causes oxidative stress, accumu- lates in and damages tissues, and enhances the growth of patho- gens. [...]the measure- ment of NTBI is of clinical im- portance, because NTBI may be used as an indicator of systemic iron overload and iron toxicity (1,2).</description><identifier>ISSN: 0009-9147</identifier><identifier>EISSN: 1530-8561</identifier><identifier>DOI: 10.1373/clinchem.2013.205302</identifier><identifier>PMID: 23669528</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Bleomycin ; Bone marrow ; Deferoxamine - chemistry ; Hematopoietic Stem Cell Transplantation ; Humans ; Indicators and Reagents ; Iron ; Iron - blood ; Iron - chemistry ; Iron Chelating Agents - chemistry ; Leukemia - blood ; Leukemia - therapy ; Methods ; Oxidation-Reduction ; Oxidative stress ; Plasma ; Protein Binding ; Stem cells ; Transferrin - metabolism</subject><ispartof>Clinical chemistry (Baltimore, Md.), 2013-08, Vol.59 (8), p.1271-1273</ispartof><rights>Copyright American Association for Clinical Chemistry Aug 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-c38adcbb78ea000e18d72139169a44b0d9a1ed3250c5d95cd6e1ce2634162c5d3</citedby><cites>FETCH-LOGICAL-c381t-c38adcbb78ea000e18d72139169a44b0d9a1ed3250c5d95cd6e1ce2634162c5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23669528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Itkonen, Outi</creatorcontrib><creatorcontrib>Vaahtera, Lauri</creatorcontrib><creatorcontrib>Parkkinen, Jaakko</creatorcontrib><title>Comparison of bleomycin-detectable iron and labile plasma iron assays</title><title>Clinical chemistry (Baltimore, Md.)</title><addtitle>Clin Chem</addtitle><description>To the Editor: Non-transferrin-bound iron (NTBI)1 is detected in the plasma of pa- tients with diseases in which the transferrin-binding capacity for iron is exceeded by a massive iron overload, such as in certain forms of thalassemia and hemochroma- tosis, repeated blood transfu- sions, or bone marrow failure. Excess iron is harmful because it causes oxidative stress, accumu- lates in and damages tissues, and enhances the growth of patho- gens. 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| ispartof | Clinical chemistry (Baltimore, Md.), 2013-08, Vol.59 (8), p.1271-1273 |
| issn | 0009-9147 1530-8561 |
| language | eng |
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| source | Oxford University Press Journals; MEDLINE |
| subjects | Bleomycin Bone marrow Deferoxamine - chemistry Hematopoietic Stem Cell Transplantation Humans Indicators and Reagents Iron Iron - blood Iron - chemistry Iron Chelating Agents - chemistry Leukemia - blood Leukemia - therapy Methods Oxidation-Reduction Oxidative stress Plasma Protein Binding Stem cells Transferrin - metabolism |
| title | Comparison of bleomycin-detectable iron and labile plasma iron assays |
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