Statistical analysis of the effects of polyethylene glycol concentration and molecular weight on the sedimentation and resuspendability behavior of model aqueous dispersions
This work investigates the flocculation effect of polyethylene glycol (PEG) on typical aqueous dispersions, such as O/W emulsions and solid/liquid suspensions. Hereby, sunflower oil and flubendazole were selected as model ingredients, whereas microfluidization at variable driving air pressure was us...
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| Veröffentlicht in: | International journal of pharmaceutics 2013-09, Vol.453 (2), p.343-350 |
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| container_title | International journal of pharmaceutics |
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| creator | Zhu, Wuxin Vermeir, Lien Govoreanu, Ruxandra Verbruggen, Katrien Ariën, Tina Van der Meeren, Paul |
| description | This work investigates the flocculation effect of polyethylene glycol (PEG) on typical aqueous dispersions, such as O/W emulsions and solid/liquid suspensions. Hereby, sunflower oil and flubendazole were selected as model ingredients, whereas microfluidization at variable driving air pressure was used to enable particle size distribution variations for both systems. The molecular weight of PEG varied from 2000 to 12,000g/mol while its concentration ranged from 50 to 100mg/ml. Statistical analysis revealed that both PEG concentration and molecular weight showed a flocculation enhancing effect. Hereby the inhibiting effect of particle size toward the formation of voluminous and easily resuspendable sediment could at least partially be overcome by selecting appropriate PEG characteristics. |
| doi_str_mv | 10.1016/j.ijpharm.2013.06.004 |
| format | Article |
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Hereby the inhibiting effect of particle size toward the formation of voluminous and easily resuspendable sediment could at least partially be overcome by selecting appropriate PEG characteristics.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2013.06.004</identifier><identifier>PMID: 23791736</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Chemistry, Pharmaceutical ; Emulsion ; Emulsions ; Flocculation ; Flubendazole suspension ; Mebendazole - analogs & derivatives ; Mebendazole - chemistry ; Molecular Weight ; Particle Size ; Plant Oils - chemistry ; Polyethylene glycol ; Polyethylene Glycols - chemistry ; Principal Component Analysis ; Regression Analysis ; Resuspendability ; Sedimentation ; Sunflower Oil ; Suspensions ; Viscosity</subject><ispartof>International journal of pharmaceutics, 2013-09, Vol.453 (2), p.343-350</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. 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Hereby, sunflower oil and flubendazole were selected as model ingredients, whereas microfluidization at variable driving air pressure was used to enable particle size distribution variations for both systems. The molecular weight of PEG varied from 2000 to 12,000g/mol while its concentration ranged from 50 to 100mg/ml. Statistical analysis revealed that both PEG concentration and molecular weight showed a flocculation enhancing effect. Hereby the inhibiting effect of particle size toward the formation of voluminous and easily resuspendable sediment could at least partially be overcome by selecting appropriate PEG characteristics.</description><subject>Chemistry, Pharmaceutical</subject><subject>Emulsion</subject><subject>Emulsions</subject><subject>Flocculation</subject><subject>Flubendazole suspension</subject><subject>Mebendazole - analogs & derivatives</subject><subject>Mebendazole - chemistry</subject><subject>Molecular Weight</subject><subject>Particle Size</subject><subject>Plant Oils - chemistry</subject><subject>Polyethylene glycol</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Principal Component Analysis</subject><subject>Regression Analysis</subject><subject>Resuspendability</subject><subject>Sedimentation</subject><subject>Sunflower Oil</subject><subject>Suspensions</subject><subject>Viscosity</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1TAQRS1ERR-FTwB5ySbBjhMnWSFUlYJUiQVlbTnOpPGTEwfbKcpH8Y9M-h6wZGV5dO7MnbmEvOEs54zL98fcHpdRhykvGBc5kzlj5TNy4E0tMlHW8jk5MFE3WcVrcUlexnhkjMmCixfkshB1i2V5IL--JZ1sTNZoR_Ws3RZtpH6gaQQKwwAmPX0X7zZI4-ZgBvrgNuMdNX42MKeADfyM4p5O3oFZnQ70J9iHMVGs740i9HZC9B8ZIK5xgbnXnXU2bbSDUT9aH_Zhk-8B3fxYwa-R9hbBEFEZX5GLQbsIr8_vFfn-6eb--nN29_X2y_XHu8wILlKmjeFSAIehxBVaWZuiYUJC3zWdHpqyxe2R1NqUumglN2UlZM26toFWiEqKK_Lu1HcJHl3EpCYbDTin592S4iWvJKuqtka0OqEm-BgDDGoJdtJhU5ypPSl1VOek1J6UYlJhUqh7ex6xdhP0f1V_okHgwwkAXPTRQlDRWMCL9zZgKqr39j8jfgOBK61Y</recordid><startdate>20130910</startdate><enddate>20130910</enddate><creator>Zhu, Wuxin</creator><creator>Vermeir, Lien</creator><creator>Govoreanu, Ruxandra</creator><creator>Verbruggen, Katrien</creator><creator>Ariën, Tina</creator><creator>Van der Meeren, Paul</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130910</creationdate><title>Statistical analysis of the effects of polyethylene glycol concentration and molecular weight on the sedimentation and resuspendability behavior of model aqueous dispersions</title><author>Zhu, Wuxin ; Vermeir, Lien ; Govoreanu, Ruxandra ; Verbruggen, Katrien ; Ariën, Tina ; Van der Meeren, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-acc163e1ef4eff967c28036edb8baf849791c31aac4a2961c453670b98e933563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Chemistry, Pharmaceutical</topic><topic>Emulsion</topic><topic>Emulsions</topic><topic>Flocculation</topic><topic>Flubendazole suspension</topic><topic>Mebendazole - analogs & derivatives</topic><topic>Mebendazole - chemistry</topic><topic>Molecular Weight</topic><topic>Particle Size</topic><topic>Plant Oils - chemistry</topic><topic>Polyethylene glycol</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Principal Component Analysis</topic><topic>Regression Analysis</topic><topic>Resuspendability</topic><topic>Sedimentation</topic><topic>Sunflower Oil</topic><topic>Suspensions</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Wuxin</creatorcontrib><creatorcontrib>Vermeir, Lien</creatorcontrib><creatorcontrib>Govoreanu, Ruxandra</creatorcontrib><creatorcontrib>Verbruggen, Katrien</creatorcontrib><creatorcontrib>Ariën, Tina</creatorcontrib><creatorcontrib>Van der Meeren, Paul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Wuxin</au><au>Vermeir, Lien</au><au>Govoreanu, Ruxandra</au><au>Verbruggen, Katrien</au><au>Ariën, Tina</au><au>Van der Meeren, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Statistical analysis of the effects of polyethylene glycol concentration and molecular weight on the sedimentation and resuspendability behavior of model aqueous dispersions</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2013-09-10</date><risdate>2013</risdate><volume>453</volume><issue>2</issue><spage>343</spage><epage>350</epage><pages>343-350</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>This work investigates the flocculation effect of polyethylene glycol (PEG) on typical aqueous dispersions, such as O/W emulsions and solid/liquid suspensions. 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| fulltext | fulltext |
| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2013-09, Vol.453 (2), p.343-350 |
| issn | 0378-5173 1873-3476 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Chemistry, Pharmaceutical Emulsion Emulsions Flocculation Flubendazole suspension Mebendazole - analogs & derivatives Mebendazole - chemistry Molecular Weight Particle Size Plant Oils - chemistry Polyethylene glycol Polyethylene Glycols - chemistry Principal Component Analysis Regression Analysis Resuspendability Sedimentation Sunflower Oil Suspensions Viscosity |
| title | Statistical analysis of the effects of polyethylene glycol concentration and molecular weight on the sedimentation and resuspendability behavior of model aqueous dispersions |
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