Blastic plasmacytoid dendritic cell neoplasm: a report of four cases and review of the literature
Background Blastic plasmacytoid dendritic cell neoplasm (BPDCN), formerly known as agranular CD4+/CD56+ haematodermic neoplasm (CD4/CD56 HN), is a rare distinct form of lymphoma‐like entity known of dermatologists because of its marked predilection for cutaneous involvement, and its aggressive beha...
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| Veröffentlicht in: | Journal of the European Academy of Dermatology and Venereology 2013-09, Vol.27 (9), p.1176-1181 |
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| container_title | Journal of the European Academy of Dermatology and Venereology |
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| creator | Borchiellini, D. Ghibaudo, N. Mounier, N. Del Giudice, P. Quinsat, D. Ticchioni, M. Perrin, C. Cardot Leccia, N. Lacour, J.P. |
| description | Background Blastic plasmacytoid dendritic cell neoplasm (BPDCN), formerly known as agranular CD4+/CD56+ haematodermic neoplasm (CD4/CD56 HN), is a rare distinct form of lymphoma‐like entity known of dermatologists because of its marked predilection for cutaneous involvement, and its aggressive behaviour. Moreover, the association or the evolution to an acute leukaemia entity that still expresses CD4 and CD56 markers is almost systematic. This new described entity of ‘CD4+/CD56+ leukaemia’ or ‘leukaemia of plasmacytoid dendritic cell lineage’ has a poor prognostic and may lead to include haematopoietic stem cell transplantation in the treatment strategy as early as possible.
Report of cases We report here four cases presenting with skin lesions and haematological signs. One of the patients underwent allogeneic stem cell transplantation, with a relapse‐free survival of 40 months. We discuss the diagnosis features as well as the treatment options.
Conclusion A collaborative work between dermatologists and onco‐haematologists is essential to give patients the best chance of complete and long‐term response. |
| doi_str_mv | 10.1111/j.1468-3083.2012.04503.x |
| format | Article |
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Report of cases We report here four cases presenting with skin lesions and haematological signs. One of the patients underwent allogeneic stem cell transplantation, with a relapse‐free survival of 40 months. We discuss the diagnosis features as well as the treatment options.
Conclusion A collaborative work between dermatologists and onco‐haematologists is essential to give patients the best chance of complete and long‐term response.</description><identifier>ISSN: 0926-9959</identifier><identifier>EISSN: 1468-3083</identifier><identifier>DOI: 10.1111/j.1468-3083.2012.04503.x</identifier><identifier>PMID: 22455538</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Dendritic Cells ; Female ; Hematologic Neoplasms - pathology ; Humans ; Male ; Middle Aged ; Skin Neoplasms - pathology</subject><ispartof>Journal of the European Academy of Dermatology and Venereology, 2013-09, Vol.27 (9), p.1176-1181</ispartof><rights>2012 The Author. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology</rights><rights>2012 The Author. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4073-2d5386d0442a98623f12602f36ec11875011ad913bf0fde8d26c233e77a326e83</citedby><cites>FETCH-LOGICAL-c4073-2d5386d0442a98623f12602f36ec11875011ad913bf0fde8d26c233e77a326e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1468-3083.2012.04503.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1468-3083.2012.04503.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22455538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borchiellini, D.</creatorcontrib><creatorcontrib>Ghibaudo, N.</creatorcontrib><creatorcontrib>Mounier, N.</creatorcontrib><creatorcontrib>Del Giudice, P.</creatorcontrib><creatorcontrib>Quinsat, D.</creatorcontrib><creatorcontrib>Ticchioni, M.</creatorcontrib><creatorcontrib>Perrin, C.</creatorcontrib><creatorcontrib>Cardot Leccia, N.</creatorcontrib><creatorcontrib>Lacour, J.P.</creatorcontrib><title>Blastic plasmacytoid dendritic cell neoplasm: a report of four cases and review of the literature</title><title>Journal of the European Academy of Dermatology and Venereology</title><addtitle>J Eur Acad Dermatol Venereol</addtitle><description>Background Blastic plasmacytoid dendritic cell neoplasm (BPDCN), formerly known as agranular CD4+/CD56+ haematodermic neoplasm (CD4/CD56 HN), is a rare distinct form of lymphoma‐like entity known of dermatologists because of its marked predilection for cutaneous involvement, and its aggressive behaviour. Moreover, the association or the evolution to an acute leukaemia entity that still expresses CD4 and CD56 markers is almost systematic. This new described entity of ‘CD4+/CD56+ leukaemia’ or ‘leukaemia of plasmacytoid dendritic cell lineage’ has a poor prognostic and may lead to include haematopoietic stem cell transplantation in the treatment strategy as early as possible.
Report of cases We report here four cases presenting with skin lesions and haematological signs. One of the patients underwent allogeneic stem cell transplantation, with a relapse‐free survival of 40 months. We discuss the diagnosis features as well as the treatment options.
Conclusion A collaborative work between dermatologists and onco‐haematologists is essential to give patients the best chance of complete and long‐term response.</description><subject>Aged</subject><subject>Dendritic Cells</subject><subject>Female</subject><subject>Hematologic Neoplasms - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Skin Neoplasms - pathology</subject><issn>0926-9959</issn><issn>1468-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkElPwzAUhC0EgrL8BeQjlwQvseMgcWDf4cJytEz8IlzSptgJbf89Di0948uzPDPPow8hTElK4zkcpjSTKuFE8ZQRylKSCcLT2RoarIR1NCAFk0lRiGILbYcwJIRQKtQm2mIsE0JwNUDmtDahdSWexDky5bxtnMUWxta7_rmEusZjaH7lI2ywh0njW9xUuGo6j0sTIGAztlH4djDthfYDcO1a8KbtPOyijcrUAfaWcwe9XF48n10n909XN2cn90mZkZwnzMY-0pIsY6ZQkvGKMklYxSWUlKpcxO7GFpS_V6SyoCyTJeMc8txwJkHxHXSw2DvxzVcHodUjF_r6JtbvgqYZFXGhojRa1cJa-iYED5WeeDcyfq4p0T1gPdQ9R91z1D1g_QtYz2J0f_lL9z4Cuwr-EY2G44Vh6mqY_3uxvj1_7W8xnyzyLrQwW-WN_9Qy57nQb49X-vyN5Y9K3OkH_gM0q5fY</recordid><startdate>201309</startdate><enddate>201309</enddate><creator>Borchiellini, D.</creator><creator>Ghibaudo, N.</creator><creator>Mounier, N.</creator><creator>Del Giudice, P.</creator><creator>Quinsat, D.</creator><creator>Ticchioni, M.</creator><creator>Perrin, C.</creator><creator>Cardot Leccia, N.</creator><creator>Lacour, J.P.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201309</creationdate><title>Blastic plasmacytoid dendritic cell neoplasm: a report of four cases and review of the literature</title><author>Borchiellini, D. ; Ghibaudo, N. ; Mounier, N. ; Del Giudice, P. ; Quinsat, D. ; Ticchioni, M. ; Perrin, C. ; Cardot Leccia, N. ; Lacour, J.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4073-2d5386d0442a98623f12602f36ec11875011ad913bf0fde8d26c233e77a326e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Dendritic Cells</topic><topic>Female</topic><topic>Hematologic Neoplasms - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Skin Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borchiellini, D.</creatorcontrib><creatorcontrib>Ghibaudo, N.</creatorcontrib><creatorcontrib>Mounier, N.</creatorcontrib><creatorcontrib>Del Giudice, P.</creatorcontrib><creatorcontrib>Quinsat, D.</creatorcontrib><creatorcontrib>Ticchioni, M.</creatorcontrib><creatorcontrib>Perrin, C.</creatorcontrib><creatorcontrib>Cardot Leccia, N.</creatorcontrib><creatorcontrib>Lacour, J.P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borchiellini, D.</au><au>Ghibaudo, N.</au><au>Mounier, N.</au><au>Del Giudice, P.</au><au>Quinsat, D.</au><au>Ticchioni, M.</au><au>Perrin, C.</au><au>Cardot Leccia, N.</au><au>Lacour, J.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blastic plasmacytoid dendritic cell neoplasm: a report of four cases and review of the literature</atitle><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle><addtitle>J Eur Acad Dermatol Venereol</addtitle><date>2013-09</date><risdate>2013</risdate><volume>27</volume><issue>9</issue><spage>1176</spage><epage>1181</epage><pages>1176-1181</pages><issn>0926-9959</issn><eissn>1468-3083</eissn><abstract>Background Blastic plasmacytoid dendritic cell neoplasm (BPDCN), formerly known as agranular CD4+/CD56+ haematodermic neoplasm (CD4/CD56 HN), is a rare distinct form of lymphoma‐like entity known of dermatologists because of its marked predilection for cutaneous involvement, and its aggressive behaviour. Moreover, the association or the evolution to an acute leukaemia entity that still expresses CD4 and CD56 markers is almost systematic. This new described entity of ‘CD4+/CD56+ leukaemia’ or ‘leukaemia of plasmacytoid dendritic cell lineage’ has a poor prognostic and may lead to include haematopoietic stem cell transplantation in the treatment strategy as early as possible.
Report of cases We report here four cases presenting with skin lesions and haematological signs. One of the patients underwent allogeneic stem cell transplantation, with a relapse‐free survival of 40 months. We discuss the diagnosis features as well as the treatment options.
Conclusion A collaborative work between dermatologists and onco‐haematologists is essential to give patients the best chance of complete and long‐term response.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22455538</pmid><doi>10.1111/j.1468-3083.2012.04503.x</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Dendritic Cells Female Hematologic Neoplasms - pathology Humans Male Middle Aged Skin Neoplasms - pathology |
| title | Blastic plasmacytoid dendritic cell neoplasm: a report of four cases and review of the literature |
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