Altered bone development and turnover in transgenic mice over-expressing Lipocalin-2 in bone

Lipocalin‐2 (LCN2) is a protein largely expressed in many tissues, associated with different biological phenomena such as cellular differentiation, inflammation and cancer acting as a survival/apoptotic signal. We found that LCN2 was expressed during osteoblast differentiation and we generated trans...

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Veröffentlicht in:	Journal of cellular physiology 2013-11, Vol.228 (11), p.2210-2221
Hauptverfasser:	Costa, Delfina, Lazzarini, Edoardo, Canciani, Barbara, Giuliani, Alessandra, SpanÒ, Raffaele, Marozzi, Katia, Manescu, Adrian, Cancedda, Ranieri, Tavella, Sara
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - metabolism Acute-Phase Proteins - metabolism Animals Animals, Newborn Body Size Bone Development Bone marrow Bone Remodeling Bone Resorption - diagnostic imaging Bone Resorption - metabolism Bone Resorption - pathology Cell Differentiation Femur - diagnostic imaging Femur - metabolism Femur - pathology Growth Plate - diagnostic imaging Growth Plate - metabolism Growth Plate - pathology Interleukin-6 - metabolism Isoenzymes - metabolism Lipocalin-2 Lipocalins - metabolism Mice Mice, Transgenic Oncogene Proteins - metabolism Organ Size Osteoblasts - metabolism Osteoclasts - metabolism Osteoclasts - pathology Radiography Receptors, Cell Surface - metabolism Reproducibility of Results Tartrate-Resistant Acid Phosphatase Transgenes - genetics
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