Chronic Effects of Trichloroethylene upon S-100 Protein Content and Lipid Composition in Gerbil Cerebellum
Gerbil rats were exposed to trichloroethylene (TCE) vapors intermittently (8 h/d) at 510 ppm or continuously at 170 ppm for five months. The cerebellar content of S-100 protein and the phospholipid fatty-acid profiles were determined. S-100 protein, a possible marker for astrocytic reactivity, indic...
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| Veröffentlicht in: | Scandinavian Journal of Work, Environment ＆ Health Environment ＆ Health, 1984-04, Vol.10 (2), p.89-93 |
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| container_end_page | 93 |
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| container_issue | 2 |
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| container_title | Scandinavian Journal of Work, Environment ＆ Health |
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| creator | Kyrklund, Titus Goracci, Gianfrancesco Haglid, Kenneth G Rosengren, Lars Porcellati, Giuseppe Kjellstrand, Per |
| description | Gerbil rats were exposed to trichloroethylene (TCE) vapors intermittently (8 h/d) at 510 ppm or continuously at 170 ppm for five months. The cerebellar content of S-100 protein and the phospholipid fatty-acid profiles were determined. S-100 protein, a possible marker for astrocytic reactivity, indicated delayed astrocytic reactivity in the anterior cerebellar hemisphere and a decrease of S-100 protein in the posterior cerebellar vermis. Minor lipid changes were observed. The fatty-acid profiles of ethanolamine phosphoglycerides showed a tendency towards alterations among the 22-carbon fatty acids, with a decrease in 22:5 (N—3), similar to those shown earlier for cerebral cortex and hippocampus of the gerbil. Two monoenoic fatty acids were decreased, the 20:1 of phosphatidyl-ethanolamine and the 18:1 of the phosphatidyl-serine. This occurrence could indicate a decrease in myelin in areas where these two fatty acids were found to be enriched. |
| doi_str_mv | 10.5271/sjweh.2353 |
| format | Article |
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The cerebellar content of S-100 protein and the phospholipid fatty-acid profiles were determined. S-100 protein, a possible marker for astrocytic reactivity, indicated delayed astrocytic reactivity in the anterior cerebellar hemisphere and a decrease of S-100 protein in the posterior cerebellar vermis. Minor lipid changes were observed. The fatty-acid profiles of ethanolamine phosphoglycerides showed a tendency towards alterations among the 22-carbon fatty acids, with a decrease in 22:5 (N—3), similar to those shown earlier for cerebral cortex and hippocampus of the gerbil. Two monoenoic fatty acids were decreased, the 20:1 of phosphatidyl-ethanolamine and the 18:1 of the phosphatidyl-serine. 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The cerebellar content of S-100 protein and the phospholipid fatty-acid profiles were determined. S-100 protein, a possible marker for astrocytic reactivity, indicated delayed astrocytic reactivity in the anterior cerebellar hemisphere and a decrease of S-100 protein in the posterior cerebellar vermis. Minor lipid changes were observed. The fatty-acid profiles of ethanolamine phosphoglycerides showed a tendency towards alterations among the 22-carbon fatty acids, with a decrease in 22:5 (N—3), similar to those shown earlier for cerebral cortex and hippocampus of the gerbil. Two monoenoic fatty acids were decreased, the 20:1 of phosphatidyl-ethanolamine and the 18:1 of the phosphatidyl-serine. 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Goracci, Gianfrancesco ; Haglid, Kenneth G ; Rosengren, Lars ; Porcellati, Giuseppe ; Kjellstrand, Per</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a434t-3f9afa9335b543c8f9052bf49549cadadbc7e42de6ca3dd54e67a4f670842e173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Cerebellum</topic><topic>Cerebellum - metabolism</topic><topic>Cerebral cortex</topic><topic>Chemical hazards</topic><topic>Fatty acids</topic><topic>Fatty Acids - metabolism</topic><topic>Gerbillinae</topic><topic>Lipid Metabolism</topic><topic>Lipids</topic><topic>Phospholipids</topic><topic>Phospholipids - metabolism</topic><topic>Plasmalogens</topic><topic>Reactivity</topic><topic>Research Design</topic><topic>S100 Proteins - metabolism</topic><topic>Solvents</topic><topic>Time Factors</topic><topic>Trichloroethylene - toxicity</topic><topic>Vapors</topic><topic>Volatilization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kyrklund, Titus</creatorcontrib><creatorcontrib>Goracci, Gianfrancesco</creatorcontrib><creatorcontrib>Haglid, Kenneth G</creatorcontrib><creatorcontrib>Rosengren, Lars</creatorcontrib><creatorcontrib>Porcellati, Giuseppe</creatorcontrib><creatorcontrib>Kjellstrand, Per</creatorcontrib><collection>Airiti Library</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Scandinavian Journal of Work, Environment ＆ Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kyrklund, Titus</au><au>Goracci, Gianfrancesco</au><au>Haglid, Kenneth G</au><au>Rosengren, Lars</au><au>Porcellati, Giuseppe</au><au>Kjellstrand, Per</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic Effects of Trichloroethylene upon S-100 Protein Content and Lipid Composition in Gerbil Cerebellum</atitle><jtitle>Scandinavian Journal of Work, Environment ＆ Health</jtitle><addtitle>Scand J Work Environ Health</addtitle><date>1984-04</date><risdate>1984</risdate><volume>10</volume><issue>2</issue><spage>89</spage><epage>93</epage><pages>89-93</pages><issn>0355-3140</issn><eissn>1795-990X</eissn><abstract>Gerbil rats were exposed to trichloroethylene (TCE) vapors intermittently (8 h/d) at 510 ppm or continuously at 170 ppm for five months. The cerebellar content of S-100 protein and the phospholipid fatty-acid profiles were determined. S-100 protein, a possible marker for astrocytic reactivity, indicated delayed astrocytic reactivity in the anterior cerebellar hemisphere and a decrease of S-100 protein in the posterior cerebellar vermis. Minor lipid changes were observed. The fatty-acid profiles of ethanolamine phosphoglycerides showed a tendency towards alterations among the 22-carbon fatty acids, with a decrease in 22:5 (N—3), similar to those shown earlier for cerebral cortex and hippocampus of the gerbil. Two monoenoic fatty acids were decreased, the 20:1 of phosphatidyl-ethanolamine and the 18:1 of the phosphatidyl-serine. 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| ispartof | Scandinavian Journal of Work, Environment ＆ Health, 1984-04, Vol.10 (2), p.89-93 |
| issn | 0355-3140 1795-990X |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; EZB Electronic Journals Library |
| subjects | Animals Cerebellum Cerebellum - metabolism Cerebral cortex Chemical hazards Fatty acids Fatty Acids - metabolism Gerbillinae Lipid Metabolism Lipids Phospholipids Phospholipids - metabolism Plasmalogens Reactivity Research Design S100 Proteins - metabolism Solvents Time Factors Trichloroethylene - toxicity Vapors Volatilization |
| title | Chronic Effects of Trichloroethylene upon S-100 Protein Content and Lipid Composition in Gerbil Cerebellum |
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