The Association of Prolonged QT Interval on Electrocardiography and Chronic Lead Exposure
OBJECTIVES:The aim of this study was to examine the association of lead exposure with cardiac conduction disturbance among lead-exposed and nonexposed workers in Taiwan. METHODS:The participants comprised 312 lead workers and 329 referents who had no known occupational lead exposure. During their an...
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| Veröffentlicht in: | Journal of occupational and environmental medicine 2013-06, Vol.55 (6), p.614-619 |
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| container_title | Journal of occupational and environmental medicine |
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| creator | Chen, Chien-Chou Yen, Hsueh-Wei Lo, Yi-Hao Chu, Yu-Hui Chiu, Yu-Wen Chuang, Hung-Yi |
| description | OBJECTIVES:The aim of this study was to examine the association of lead exposure with cardiac conduction disturbance among lead-exposed and nonexposed workers in Taiwan.
METHODS:The participants comprised 312 lead workers and 329 referents who had no known occupational lead exposure. During their annual health examination, they were invited to take part in the survey. Standard resting 12-lead electrocardiograms were obtained and the electrocardiographic features studied were related to blood lead levels (BLLs).
RESULTS:The mean BLLs were 26.05 (SD = 13.98) and 2.62 (SD = 1.42) μg/dL in lead-exposed and reference groups, respectively. Compared with the referents, lead workers had significantly shorter PR interval and longer QTc interval. Especially, workers with BLL > 30 μg/dL had the highest risk after adjusting for age, sex, body mass index, and other potential confounders.
CONCLUSION:The data suggest that lead exposure is positively associated with prolonged QTc interval. |
| doi_str_mv | 10.1097/JOM.0b013e318291787a |
| format | Article |
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METHODS:The participants comprised 312 lead workers and 329 referents who had no known occupational lead exposure. During their annual health examination, they were invited to take part in the survey. Standard resting 12-lead electrocardiograms were obtained and the electrocardiographic features studied were related to blood lead levels (BLLs).
RESULTS:The mean BLLs were 26.05 (SD = 13.98) and 2.62 (SD = 1.42) μg/dL in lead-exposed and reference groups, respectively. Compared with the referents, lead workers had significantly shorter PR interval and longer QTc interval. Especially, workers with BLL > 30 μg/dL had the highest risk after adjusting for age, sex, body mass index, and other potential confounders.
CONCLUSION:The data suggest that lead exposure is positively associated with prolonged QTc interval.</description><identifier>ISSN: 1076-2752</identifier><identifier>EISSN: 1536-5948</identifier><identifier>DOI: 10.1097/JOM.0b013e318291787a</identifier><identifier>PMID: 23722940</identifier><identifier>CODEN: JOEMFM</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, a business of Wolters Kluwer Health</publisher><subject>Adult ; Arrhythmias, Cardiac - chemically induced ; Arrhythmias, Cardiac - physiopathology ; Biological and medical sciences ; Blood Pressure ; Body mass index ; Cardiac dysrhythmias ; Cardiology. Vascular system ; Chemical and industrial products toxicology. Toxic occupational diseases ; Correlation analysis ; Electric Power Supplies ; Electrocardiography ; Electrocardiography - drug effects ; Female ; Heart ; Heart - physiopathology ; Heart Conduction System - drug effects ; Human exposure ; Humans ; Lead ; Lead - blood ; Lead - toxicity ; Male ; Medical sciences ; Metals and various inorganic compounds ; Middle Aged ; Occupational Exposure - adverse effects ; Occupational health ; Occupational medicine ; Original Article ; Public health. Hygiene-occupational medicine ; Taiwan ; Toxicology</subject><ispartof>Journal of occupational and environmental medicine, 2013-06, Vol.55 (6), p.614-619</ispartof><rights>Copyright © 2013 by American College of Occupational and Environmental Medicine</rights><rights>2013The American College of Occupational and Environmental Medicine</rights><rights>2014 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Jun 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4655-1c3e7e3c996378c6ea21ee133e06603f50941f638f68a13cdd129b5af248c4493</citedby><cites>FETCH-LOGICAL-c4655-1c3e7e3c996378c6ea21ee133e06603f50941f638f68a13cdd129b5af248c4493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/48509469$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/48509469$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27465177$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23722940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Chien-Chou</creatorcontrib><creatorcontrib>Yen, Hsueh-Wei</creatorcontrib><creatorcontrib>Lo, Yi-Hao</creatorcontrib><creatorcontrib>Chu, Yu-Hui</creatorcontrib><creatorcontrib>Chiu, Yu-Wen</creatorcontrib><creatorcontrib>Chuang, Hung-Yi</creatorcontrib><title>The Association of Prolonged QT Interval on Electrocardiography and Chronic Lead Exposure</title><title>Journal of occupational and environmental medicine</title><addtitle>J Occup Environ Med</addtitle><description>OBJECTIVES:The aim of this study was to examine the association of lead exposure with cardiac conduction disturbance among lead-exposed and nonexposed workers in Taiwan.
METHODS:The participants comprised 312 lead workers and 329 referents who had no known occupational lead exposure. During their annual health examination, they were invited to take part in the survey. Standard resting 12-lead electrocardiograms were obtained and the electrocardiographic features studied were related to blood lead levels (BLLs).
RESULTS:The mean BLLs were 26.05 (SD = 13.98) and 2.62 (SD = 1.42) μg/dL in lead-exposed and reference groups, respectively. Compared with the referents, lead workers had significantly shorter PR interval and longer QTc interval. Especially, workers with BLL > 30 μg/dL had the highest risk after adjusting for age, sex, body mass index, and other potential confounders.
CONCLUSION:The data suggest that lead exposure is positively associated with prolonged QTc interval.</description><subject>Adult</subject><subject>Arrhythmias, Cardiac - chemically induced</subject><subject>Arrhythmias, Cardiac - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Body mass index</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiology. Vascular system</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Correlation analysis</subject><subject>Electric Power Supplies</subject><subject>Electrocardiography</subject><subject>Electrocardiography - drug effects</subject><subject>Female</subject><subject>Heart</subject><subject>Heart - physiopathology</subject><subject>Heart Conduction System - drug effects</subject><subject>Human exposure</subject><subject>Humans</subject><subject>Lead</subject><subject>Lead - blood</subject><subject>Lead - toxicity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Middle Aged</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational health</subject><subject>Occupational medicine</subject><subject>Original Article</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Taiwan</subject><subject>Toxicology</subject><issn>1076-2752</issn><issn>1536-5948</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhiMEoh_wDwBZQkhcUjz-jI_VaoGiRQVpOXCKvM6kyeKNt3ZC23-Pl11aqScOlj3yM--rmbcoXgE9A2r0hy-XX8_oigJHDhUzoCttnxTHILkqpRHV0_ymWpVMS3ZUnKS0phQkUPm8OGJcM2YEPS5-Ljsk5ykF19uxDwMJLfkWgw_DFTbk-5JcDCPG39aT_Df36MYYnI1NH66i3XZ3xA4NmXUxDL0jC7QNmd9uQ5oiviietdYnfHm4T4sfH-fL2edycfnpYna-KJ1QUpbgOGrkzhjFdeUUWgaIwDlSpShvJTUCWsWrVlUWuGsaYGYlbctE5YQw_LR4v9fdxnA9YRrrTZ8cem8HDFOqQQAHpQyj_4MyCZWmMqNvH6HrMMUhD1IDV5pqULDzFnvKxZBSxLbexn5j410NtN6lVOeU6scp5bY3B_FptcHmvulfLBl4dwBscta30Q6uTw-czqsDrR_8b4LPMaVffrrBWHdo_djVlFLBtRIly_5U5bLM5-9wr_dt6zSGeC8rqt2yleF_ADs1scc</recordid><startdate>201306</startdate><enddate>201306</enddate><creator>Chen, Chien-Chou</creator><creator>Yen, Hsueh-Wei</creator><creator>Lo, Yi-Hao</creator><creator>Chu, Yu-Hui</creator><creator>Chiu, Yu-Wen</creator><creator>Chuang, Hung-Yi</creator><general>Lippincott Williams & Wilkins, a business of Wolters Kluwer Health</general><general>The American College of Occupational and Environmental Medicine</general><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7U1</scope><scope>7U2</scope><scope>7X8</scope></search><sort><creationdate>201306</creationdate><title>The Association of Prolonged QT Interval on Electrocardiography and Chronic Lead Exposure</title><author>Chen, Chien-Chou ; Yen, Hsueh-Wei ; Lo, Yi-Hao ; Chu, Yu-Hui ; Chiu, Yu-Wen ; Chuang, Hung-Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4655-1c3e7e3c996378c6ea21ee133e06603f50941f638f68a13cdd129b5af248c4493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Arrhythmias, Cardiac - chemically induced</topic><topic>Arrhythmias, Cardiac - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Body mass index</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiology. Vascular system</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Correlation analysis</topic><topic>Electric Power Supplies</topic><topic>Electrocardiography</topic><topic>Electrocardiography - drug effects</topic><topic>Female</topic><topic>Heart</topic><topic>Heart - physiopathology</topic><topic>Heart Conduction System - drug effects</topic><topic>Human exposure</topic><topic>Humans</topic><topic>Lead</topic><topic>Lead - blood</topic><topic>Lead - toxicity</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Middle Aged</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupational health</topic><topic>Occupational medicine</topic><topic>Original Article</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Taiwan</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Chien-Chou</creatorcontrib><creatorcontrib>Yen, Hsueh-Wei</creatorcontrib><creatorcontrib>Lo, Yi-Hao</creatorcontrib><creatorcontrib>Chu, Yu-Hui</creatorcontrib><creatorcontrib>Chiu, Yu-Wen</creatorcontrib><creatorcontrib>Chuang, Hung-Yi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of occupational and environmental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Chien-Chou</au><au>Yen, Hsueh-Wei</au><au>Lo, Yi-Hao</au><au>Chu, Yu-Hui</au><au>Chiu, Yu-Wen</au><au>Chuang, Hung-Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Association of Prolonged QT Interval on Electrocardiography and Chronic Lead Exposure</atitle><jtitle>Journal of occupational and environmental medicine</jtitle><addtitle>J Occup Environ Med</addtitle><date>2013-06</date><risdate>2013</risdate><volume>55</volume><issue>6</issue><spage>614</spage><epage>619</epage><pages>614-619</pages><issn>1076-2752</issn><eissn>1536-5948</eissn><coden>JOEMFM</coden><abstract>OBJECTIVES:The aim of this study was to examine the association of lead exposure with cardiac conduction disturbance among lead-exposed and nonexposed workers in Taiwan.
METHODS:The participants comprised 312 lead workers and 329 referents who had no known occupational lead exposure. During their annual health examination, they were invited to take part in the survey. Standard resting 12-lead electrocardiograms were obtained and the electrocardiographic features studied were related to blood lead levels (BLLs).
RESULTS:The mean BLLs were 26.05 (SD = 13.98) and 2.62 (SD = 1.42) μg/dL in lead-exposed and reference groups, respectively. Compared with the referents, lead workers had significantly shorter PR interval and longer QTc interval. Especially, workers with BLL > 30 μg/dL had the highest risk after adjusting for age, sex, body mass index, and other potential confounders.
CONCLUSION:The data suggest that lead exposure is positively associated with prolonged QTc interval.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, a business of Wolters Kluwer Health</pub><pmid>23722940</pmid><doi>10.1097/JOM.0b013e318291787a</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of occupational and environmental medicine, 2013-06, Vol.55 (6), p.614-619 |
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| subjects | Adult Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - physiopathology Biological and medical sciences Blood Pressure Body mass index Cardiac dysrhythmias Cardiology. Vascular system Chemical and industrial products toxicology. Toxic occupational diseases Correlation analysis Electric Power Supplies Electrocardiography Electrocardiography - drug effects Female Heart Heart - physiopathology Heart Conduction System - drug effects Human exposure Humans Lead Lead - blood Lead - toxicity Male Medical sciences Metals and various inorganic compounds Middle Aged Occupational Exposure - adverse effects Occupational health Occupational medicine Original Article Public health. Hygiene-occupational medicine Taiwan Toxicology |
| title | The Association of Prolonged QT Interval on Electrocardiography and Chronic Lead Exposure |
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