Microchimerism in the human brain: More questions than answers
Recently, our group reported the presence of microchimerism (Mc) in the human brain by performing quantitative PCR on female human brain tissues to amplify male DNA. We found brain Mc to be relatively frequent in humans and widely distributed in this organ. Our data also suggested a lower prevalence...
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| Veröffentlicht in: | Chimerism 2013-01, Vol.4 (1), p.32-33 |
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| creator | Chan, William F.N. Nelson, J. Lee |
| description | Recently, our group reported the presence of microchimerism (Mc) in the human brain by performing quantitative PCR on female human brain tissues to amplify male DNA. We found brain Mc to be relatively frequent in humans and widely distributed in this organ. Our data also suggested a lower prevalence of brain Mc in women without Alzheimer disease than women without neurological disease. Altogether, these findings suggest that Mc could sometimes influence health and disease of the brain. As further research will be required to clarify this issue, here we discuss some of the questions that could be addressed to improve our understanding. |
| doi_str_mv | 10.4161/chim.24072 |
| format | Article |
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As further research will be required to clarify this issue, here we discuss some of the questions that could be addressed to improve our understanding.</description><identifier>ISSN: 1938-1956</identifier><identifier>EISSN: 1938-1964</identifier><identifier>DOI: 10.4161/chim.24072</identifier><identifier>PMID: 23434631</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Addendum ; Alzheimer disease ; Alzheimer Disease - epidemiology ; Alzheimer Disease - immunology ; blood-brain barrier ; Blood-Brain Barrier - immunology ; brain ; Brain - immunology ; Chimerism ; DNA - genetics ; Female ; Humans ; Male ; microchimerism ; Pregnancy</subject><ispartof>Chimerism, 2013-01, Vol.4 (1), p.32-33</ispartof><rights>Copyright © 2013 Landes Bioscience 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c332t-bf1727a4f7a414efbf25e86f62805f8c4a5c673d63b91375e92b8ed1af8b6e603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654737/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654737/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23434631$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, William F.N.</creatorcontrib><creatorcontrib>Nelson, J. 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As further research will be required to clarify this issue, here we discuss some of the questions that could be addressed to improve our understanding.</description><subject>Addendum</subject><subject>Alzheimer disease</subject><subject>Alzheimer Disease - epidemiology</subject><subject>Alzheimer Disease - immunology</subject><subject>blood-brain barrier</subject><subject>Blood-Brain Barrier - immunology</subject><subject>brain</subject><subject>Brain - immunology</subject><subject>Chimerism</subject><subject>DNA - genetics</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>microchimerism</subject><subject>Pregnancy</subject><issn>1938-1956</issn><issn>1938-1964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1LxDAQhoMo7rp68QdIvYnQtfnopHsRZPELFC96Dmma2EibrEmr7L-3666LgocwgXl4ZuZF6BhnU4YBX6jatlPCMk520BjPaJHiGbDd7T-HETqI8S3LgBJM9tGIUEYZUDxGp49WBb8y6GBjm1iXdLVO6r6VLimDtO4Q7RnZRH20qRP0cnP9PL9LH55u7-dXD6milHRpaTAnXDIzPMy0KQ3JdQEGSJHlplBM5go4rYCWM0x5rmekLHSFpSlK0JDRCbpcexd92epKadcF2YhFsK0MS-GlFX87ztbi1X8ICjnjlA-Cs40g-Pdex060NirdNNJp30eBGaYYADgb0PM1OtweY9BmOwZnYpWpWCUivjMd4JPfi23RnxAHIF8D1hkfWvnpQ1OJTi4bH0yQTtko6D_iLwnPhJA</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Chan, William F.N.</creator><creator>Nelson, J. 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Lee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-bf1727a4f7a414efbf25e86f62805f8c4a5c673d63b91375e92b8ed1af8b6e603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Addendum</topic><topic>Alzheimer disease</topic><topic>Alzheimer Disease - epidemiology</topic><topic>Alzheimer Disease - immunology</topic><topic>blood-brain barrier</topic><topic>Blood-Brain Barrier - immunology</topic><topic>brain</topic><topic>Brain - immunology</topic><topic>Chimerism</topic><topic>DNA - genetics</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>microchimerism</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, William F.N.</creatorcontrib><creatorcontrib>Nelson, J. 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Lee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microchimerism in the human brain: More questions than answers</atitle><jtitle>Chimerism</jtitle><addtitle>Chimerism</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>4</volume><issue>1</issue><spage>32</spage><epage>33</epage><pages>32-33</pages><issn>1938-1956</issn><eissn>1938-1964</eissn><abstract>Recently, our group reported the presence of microchimerism (Mc) in the human brain by performing quantitative PCR on female human brain tissues to amplify male DNA. We found brain Mc to be relatively frequent in humans and widely distributed in this organ. Our data also suggested a lower prevalence of brain Mc in women without Alzheimer disease than women without neurological disease. Altogether, these findings suggest that Mc could sometimes influence health and disease of the brain. 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| identifier | ISSN: 1938-1956 |
| ispartof | Chimerism, 2013-01, Vol.4 (1), p.32-33 |
| issn | 1938-1956 1938-1964 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Addendum Alzheimer disease Alzheimer Disease - epidemiology Alzheimer Disease - immunology blood-brain barrier Blood-Brain Barrier - immunology brain Brain - immunology Chimerism DNA - genetics Female Humans Male microchimerism Pregnancy |
| title | Microchimerism in the human brain: More questions than answers |
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