Microscopic Colitis in Children With Chronic Diarrhea
ABSTRACT Objective: The aim of the present study was to study microscopic colitis (MC) in children with special reference to its role in chronic diarrhea and changes in mucosal biopsies. Methods: A total of 100 consecutive children ages 3 to 12 years, with nonbloody diarrhea (passage of ≥3 loose sto...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 2013-08, Vol.57 (2), p.240-244 |
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| creator | Singh, Prashant Das, Prasenjit Jain, A.K. Mathan, Minnie Mathur, Meera Bhat, Abdus Sami Varma, Sharat Chaturvedi, Mona K. Gupta, Siddhartha Datta Bhatnagar, Shinjini |
| description | ABSTRACT
Objective:
The aim of the present study was to study microscopic colitis (MC) in children with special reference to its role in chronic diarrhea and changes in mucosal biopsies.
Methods:
A total of 100 consecutive children ages 3 to 12 years, with nonbloody diarrhea (passage of ≥3 loose stools per day) of >12 weeks' duration were screened and 26 were enrolled in the study in which no specific etiology could be found and colonoscopy did not reveal any mucosal abnormality. Colonic biopsies were evaluated for the presence of lymphocytic colitis or collagenous colitis and those with the characteristic changes were defined to have MC (group A). Colonic biopsies from patients with MC were compared with biopsies from patients with chronic diarrhea but no evidence of MC (group B). One hundred children ages 3 to 12 years with bleeding per rectum were screened and colonic biopsies from 45 patients (group C) who had colonic mucosal changes but no vascular or polyp lesion were compared with patients with MC.
Results:
Of the 26 patients with chronic diarrhea, MC was found in 5 (3 lymphocytic colitis and 2 collagenous colitis). Significantly higher polymorphonuclear infiltration was seen in group A as compared with group B (13.8 [5.4–20.6] vs 7.2 [0–19.6]; P = 0.03) or group C (13.8 [5.4–20.6] vs 4 [0–13.4]; P = 0.007). Intraepithelial lymphocytes (12 [4–32] vs 4 [0–24]; P = 0.008) and basement membrane thickening (3.5 [2.9–10.6] vs 2.5 [1.6–5.86]; P = 0.008) were also significantly higher in group A as compared with group C.
Conclusions:
MC was found to be present in children with nonbloody chronic diarrhea in children. Further multicentric studies may provide adequate data on its prevalence. |
| doi_str_mv | 10.1097/MPG.0b013e3182942868 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1413162452</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1413162452</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4821-9f0fceeeb915abbfe2eacb4ee8641f482a3fa8347c15fd3dcc51c7452efd69163</originalsourceid><addsrcrecordid>eNqNkM1OGzEURq0KVALtG6AqG6RuBnz9N55FFzQtFASUBahLy-O5Vtw6M8GeCOXtcUQoEisWlnWl8_m7PoQcAj0G2tQn17fnx7SlwJGDZo1gWukPZAKSq0poCjtkQlldVwxA7ZH9nP9SSmsh6Ueyx7gUDWdyQuR1cGnIblgGN50NMYwhT0M_nc1D7BL20z9hnJcpDX0BfgSb0hztJ7Lrbcz4eXsfkPuzn3ezX9XV7_OL2elV5YRmUDWeeoeIbQPStq1Hhta1AlErAb4glnuruagdSN_xzjkJrqzI0HeqAcUPyNfnd5dpeFhhHs0iZIcx2h6HVTYggINiJVFQ8YxuvpMTerNMYWHT2gA1G2GmCDNvhZXYl23Dql1g9z_0YqgAR1vAZmejT7Z3Ib9ytaxBNvDa_zjEEVP-F1ePmEyRFce5KeqphFpVrPRTXaaqHLaJfdvGQsT1u3Y2l7c3_PsZVVJz_gQLYJTZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1413162452</pqid></control><display><type>article</type><title>Microscopic Colitis in Children With Chronic Diarrhea</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>Wiley Online Library All Journals</source><creator>Singh, Prashant ; Das, Prasenjit ; Jain, A.K. ; Mathan, Minnie ; Mathur, Meera ; Bhat, Abdus Sami ; Varma, Sharat ; Chaturvedi, Mona K. ; Gupta, Siddhartha Datta ; Bhatnagar, Shinjini</creator><creatorcontrib>Singh, Prashant ; Das, Prasenjit ; Jain, A.K. ; Mathan, Minnie ; Mathur, Meera ; Bhat, Abdus Sami ; Varma, Sharat ; Chaturvedi, Mona K. ; Gupta, Siddhartha Datta ; Bhatnagar, Shinjini</creatorcontrib><description>ABSTRACT
Objective:
The aim of the present study was to study microscopic colitis (MC) in children with special reference to its role in chronic diarrhea and changes in mucosal biopsies.
Methods:
A total of 100 consecutive children ages 3 to 12 years, with nonbloody diarrhea (passage of ≥3 loose stools per day) of >12 weeks' duration were screened and 26 were enrolled in the study in which no specific etiology could be found and colonoscopy did not reveal any mucosal abnormality. Colonic biopsies were evaluated for the presence of lymphocytic colitis or collagenous colitis and those with the characteristic changes were defined to have MC (group A). Colonic biopsies from patients with MC were compared with biopsies from patients with chronic diarrhea but no evidence of MC (group B). One hundred children ages 3 to 12 years with bleeding per rectum were screened and colonic biopsies from 45 patients (group C) who had colonic mucosal changes but no vascular or polyp lesion were compared with patients with MC.
Results:
Of the 26 patients with chronic diarrhea, MC was found in 5 (3 lymphocytic colitis and 2 collagenous colitis). Significantly higher polymorphonuclear infiltration was seen in group A as compared with group B (13.8 [5.4–20.6] vs 7.2 [0–19.6]; P = 0.03) or group C (13.8 [5.4–20.6] vs 4 [0–13.4]; P = 0.007). Intraepithelial lymphocytes (12 [4–32] vs 4 [0–24]; P = 0.008) and basement membrane thickening (3.5 [2.9–10.6] vs 2.5 [1.6–5.86]; P = 0.008) were also significantly higher in group A as compared with group C.
Conclusions:
MC was found to be present in children with nonbloody chronic diarrhea in children. Further multicentric studies may provide adequate data on its prevalence.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1097/MPG.0b013e3182942868</identifier><identifier>PMID: 23549325</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</publisher><subject>Biological and medical sciences ; Biopsy ; Child ; Child, Preschool ; Chronic Disease ; Colitis, Collagenous - complications ; Colitis, Collagenous - epidemiology ; Colitis, Collagenous - pathology ; Colitis, Lymphocytic - complications ; Colitis, Lymphocytic - epidemiology ; Colitis, Lymphocytic - pathology ; collagenous colitis ; Colonoscopy ; Diarrhea - etiology ; Diarrhea - pathology ; diarrhea in children ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Intestinal Mucosa - pathology ; Lymphocytes - pathology ; lymphocytic colitis ; Male ; Medical sciences ; microscopic colitis ; Neutrophil Infiltration ; Neutrophils ; Other diseases. Semiology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 2013-08, Vol.57 (2), p.240-244</ispartof><rights>2013 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>2013 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4821-9f0fceeeb915abbfe2eacb4ee8641f482a3fa8347c15fd3dcc51c7452efd69163</citedby><cites>FETCH-LOGICAL-c4821-9f0fceeeb915abbfe2eacb4ee8641f482a3fa8347c15fd3dcc51c7452efd69163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2FMPG.0b013e3182942868$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2FMPG.0b013e3182942868$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27571591$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23549325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Prashant</creatorcontrib><creatorcontrib>Das, Prasenjit</creatorcontrib><creatorcontrib>Jain, A.K.</creatorcontrib><creatorcontrib>Mathan, Minnie</creatorcontrib><creatorcontrib>Mathur, Meera</creatorcontrib><creatorcontrib>Bhat, Abdus Sami</creatorcontrib><creatorcontrib>Varma, Sharat</creatorcontrib><creatorcontrib>Chaturvedi, Mona K.</creatorcontrib><creatorcontrib>Gupta, Siddhartha Datta</creatorcontrib><creatorcontrib>Bhatnagar, Shinjini</creatorcontrib><title>Microscopic Colitis in Children With Chronic Diarrhea</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>ABSTRACT
Objective:
The aim of the present study was to study microscopic colitis (MC) in children with special reference to its role in chronic diarrhea and changes in mucosal biopsies.
Methods:
A total of 100 consecutive children ages 3 to 12 years, with nonbloody diarrhea (passage of ≥3 loose stools per day) of >12 weeks' duration were screened and 26 were enrolled in the study in which no specific etiology could be found and colonoscopy did not reveal any mucosal abnormality. Colonic biopsies were evaluated for the presence of lymphocytic colitis or collagenous colitis and those with the characteristic changes were defined to have MC (group A). Colonic biopsies from patients with MC were compared with biopsies from patients with chronic diarrhea but no evidence of MC (group B). One hundred children ages 3 to 12 years with bleeding per rectum were screened and colonic biopsies from 45 patients (group C) who had colonic mucosal changes but no vascular or polyp lesion were compared with patients with MC.
Results:
Of the 26 patients with chronic diarrhea, MC was found in 5 (3 lymphocytic colitis and 2 collagenous colitis). Significantly higher polymorphonuclear infiltration was seen in group A as compared with group B (13.8 [5.4–20.6] vs 7.2 [0–19.6]; P = 0.03) or group C (13.8 [5.4–20.6] vs 4 [0–13.4]; P = 0.007). Intraepithelial lymphocytes (12 [4–32] vs 4 [0–24]; P = 0.008) and basement membrane thickening (3.5 [2.9–10.6] vs 2.5 [1.6–5.86]; P = 0.008) were also significantly higher in group A as compared with group C.
Conclusions:
MC was found to be present in children with nonbloody chronic diarrhea in children. Further multicentric studies may provide adequate data on its prevalence.</description><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chronic Disease</subject><subject>Colitis, Collagenous - complications</subject><subject>Colitis, Collagenous - epidemiology</subject><subject>Colitis, Collagenous - pathology</subject><subject>Colitis, Lymphocytic - complications</subject><subject>Colitis, Lymphocytic - epidemiology</subject><subject>Colitis, Lymphocytic - pathology</subject><subject>collagenous colitis</subject><subject>Colonoscopy</subject><subject>Diarrhea - etiology</subject><subject>Diarrhea - pathology</subject><subject>diarrhea in children</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Intestinal Mucosa - pathology</subject><subject>Lymphocytes - pathology</subject><subject>lymphocytic colitis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>microscopic colitis</subject><subject>Neutrophil Infiltration</subject><subject>Neutrophils</subject><subject>Other diseases. Semiology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1OGzEURq0KVALtG6AqG6RuBnz9N55FFzQtFASUBahLy-O5Vtw6M8GeCOXtcUQoEisWlnWl8_m7PoQcAj0G2tQn17fnx7SlwJGDZo1gWukPZAKSq0poCjtkQlldVwxA7ZH9nP9SSmsh6Ueyx7gUDWdyQuR1cGnIblgGN50NMYwhT0M_nc1D7BL20z9hnJcpDX0BfgSb0hztJ7Lrbcz4eXsfkPuzn3ezX9XV7_OL2elV5YRmUDWeeoeIbQPStq1Hhta1AlErAb4glnuruagdSN_xzjkJrqzI0HeqAcUPyNfnd5dpeFhhHs0iZIcx2h6HVTYggINiJVFQ8YxuvpMTerNMYWHT2gA1G2GmCDNvhZXYl23Dql1g9z_0YqgAR1vAZmejT7Z3Ib9ytaxBNvDa_zjEEVP-F1ePmEyRFce5KeqphFpVrPRTXaaqHLaJfdvGQsT1u3Y2l7c3_PsZVVJz_gQLYJTZ</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Singh, Prashant</creator><creator>Das, Prasenjit</creator><creator>Jain, A.K.</creator><creator>Mathan, Minnie</creator><creator>Mathur, Meera</creator><creator>Bhat, Abdus Sami</creator><creator>Varma, Sharat</creator><creator>Chaturvedi, Mona K.</creator><creator>Gupta, Siddhartha Datta</creator><creator>Bhatnagar, Shinjini</creator><general>by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201308</creationdate><title>Microscopic Colitis in Children With Chronic Diarrhea</title><author>Singh, Prashant ; Das, Prasenjit ; Jain, A.K. ; Mathan, Minnie ; Mathur, Meera ; Bhat, Abdus Sami ; Varma, Sharat ; Chaturvedi, Mona K. ; Gupta, Siddhartha Datta ; Bhatnagar, Shinjini</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4821-9f0fceeeb915abbfe2eacb4ee8641f482a3fa8347c15fd3dcc51c7452efd69163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chronic Disease</topic><topic>Colitis, Collagenous - complications</topic><topic>Colitis, Collagenous - epidemiology</topic><topic>Colitis, Collagenous - pathology</topic><topic>Colitis, Lymphocytic - complications</topic><topic>Colitis, Lymphocytic - epidemiology</topic><topic>Colitis, Lymphocytic - pathology</topic><topic>collagenous colitis</topic><topic>Colonoscopy</topic><topic>Diarrhea - etiology</topic><topic>Diarrhea - pathology</topic><topic>diarrhea in children</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Intestinal Mucosa - pathology</topic><topic>Lymphocytes - pathology</topic><topic>lymphocytic colitis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>microscopic colitis</topic><topic>Neutrophil Infiltration</topic><topic>Neutrophils</topic><topic>Other diseases. Semiology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Prashant</creatorcontrib><creatorcontrib>Das, Prasenjit</creatorcontrib><creatorcontrib>Jain, A.K.</creatorcontrib><creatorcontrib>Mathan, Minnie</creatorcontrib><creatorcontrib>Mathur, Meera</creatorcontrib><creatorcontrib>Bhat, Abdus Sami</creatorcontrib><creatorcontrib>Varma, Sharat</creatorcontrib><creatorcontrib>Chaturvedi, Mona K.</creatorcontrib><creatorcontrib>Gupta, Siddhartha Datta</creatorcontrib><creatorcontrib>Bhatnagar, Shinjini</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Prashant</au><au>Das, Prasenjit</au><au>Jain, A.K.</au><au>Mathan, Minnie</au><au>Mathur, Meera</au><au>Bhat, Abdus Sami</au><au>Varma, Sharat</au><au>Chaturvedi, Mona K.</au><au>Gupta, Siddhartha Datta</au><au>Bhatnagar, Shinjini</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microscopic Colitis in Children With Chronic Diarrhea</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>2013-08</date><risdate>2013</risdate><volume>57</volume><issue>2</issue><spage>240</spage><epage>244</epage><pages>240-244</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>ABSTRACT
Objective:
The aim of the present study was to study microscopic colitis (MC) in children with special reference to its role in chronic diarrhea and changes in mucosal biopsies.
Methods:
A total of 100 consecutive children ages 3 to 12 years, with nonbloody diarrhea (passage of ≥3 loose stools per day) of >12 weeks' duration were screened and 26 were enrolled in the study in which no specific etiology could be found and colonoscopy did not reveal any mucosal abnormality. Colonic biopsies were evaluated for the presence of lymphocytic colitis or collagenous colitis and those with the characteristic changes were defined to have MC (group A). Colonic biopsies from patients with MC were compared with biopsies from patients with chronic diarrhea but no evidence of MC (group B). One hundred children ages 3 to 12 years with bleeding per rectum were screened and colonic biopsies from 45 patients (group C) who had colonic mucosal changes but no vascular or polyp lesion were compared with patients with MC.
Results:
Of the 26 patients with chronic diarrhea, MC was found in 5 (3 lymphocytic colitis and 2 collagenous colitis). Significantly higher polymorphonuclear infiltration was seen in group A as compared with group B (13.8 [5.4–20.6] vs 7.2 [0–19.6]; P = 0.03) or group C (13.8 [5.4–20.6] vs 4 [0–13.4]; P = 0.007). Intraepithelial lymphocytes (12 [4–32] vs 4 [0–24]; P = 0.008) and basement membrane thickening (3.5 [2.9–10.6] vs 2.5 [1.6–5.86]; P = 0.008) were also significantly higher in group A as compared with group C.
Conclusions:
MC was found to be present in children with nonbloody chronic diarrhea in children. Further multicentric studies may provide adequate data on its prevalence.</abstract><cop>Hagerstown, MD</cop><pub>by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</pub><pmid>23549325</pmid><doi>10.1097/MPG.0b013e3182942868</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | Biological and medical sciences Biopsy Child Child, Preschool Chronic Disease Colitis, Collagenous - complications Colitis, Collagenous - epidemiology Colitis, Collagenous - pathology Colitis, Lymphocytic - complications Colitis, Lymphocytic - epidemiology Colitis, Lymphocytic - pathology collagenous colitis Colonoscopy Diarrhea - etiology Diarrhea - pathology diarrhea in children Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Humans Intestinal Mucosa - pathology Lymphocytes - pathology lymphocytic colitis Male Medical sciences microscopic colitis Neutrophil Infiltration Neutrophils Other diseases. Semiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Microscopic Colitis in Children With Chronic Diarrhea |
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