Transcriptional regulation of MDR-1 by HOXC6 in multidrug-resistant cells

Resistance to chemotherapeutic drugs is a significant clinical problem in the treatment of cancer and this resistance has been linked to the cellular expression of multidrug-efflux transporters. The aim of this study was to explore the role of HOXC6 in the regulation of multidrug resistance (MDR) to...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2013-07, Vol.32 (28), p.3339-3349
Hauptverfasser:	Kim, K-J, Moon, S-M, Kim, S-A, Kang, K-W, Yoon, J-H, Ahn, S-G
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/612/822 631/67/1059/2326 631/67/1059/99 631/92/609 Analysis Antineoplastic Agents - pharmacology Apoptosis Apoptosis - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Base Sequence Binding Sites Cancer Cell Biology Cell Line, Tumor Cells Chemotherapy Deletion mutant Drug resistance Drug Resistance, Multiple - genetics Drug Resistance, Neoplasm - genetics Flow cytometry Gene deletion Gene Expression Regulation, Neoplastic - drug effects Gene regulation Genetic transcription Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Human Genetics Humans Internal Medicine Intracellular Space - drug effects Intracellular Space - metabolism MDR1 protein Medicine Medicine & Public Health Molecular Sequence Data Multidrug resistance Multidrug resistant organisms Oncology original-article P-Glycoprotein Paclitaxel Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - genetics Rhodamine 123 - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics siRNA Transcription Transcription, Genetic - drug effects Transfection Up-Regulation - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!