The neuroprotection effect of pretreatment with olive leaf extract on brain lipidomics in rat stroke model
Recent studies suggest that olive extracts suppress inflammation and reduce stress oxidative injury. We have attempted to determine the effect of dietary olive leaf extract (OLE) on brain lipidomics in rat stroke model. Five groups, each consisting of 12 male Wistar rats, were studied. First and sec...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2012-07, Vol.19 (10), p.940-946 |
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| creator | Rabiei, Zahra Bigdeli, Mohammad Reza Rasoulian, Bahram Ghassempour, Alireza Mirzajani, Fatemeh |
| description | Recent studies suggest that olive extracts suppress inflammation and reduce stress oxidative injury. We have attempted to determine the effect of dietary olive leaf extract (OLE) on brain lipidomics in rat stroke model.
Five groups, each consisting of 12 male Wistar rats, were studied. First and second groups (control, and sham) received distilled water, while three treatment groups received oral olive leaf extract (OLE) for 30days (50, 75 and 100mg/kg/day, respectively). Two hours after the last dose, each main group was subdivided to Middle cerebral artery occlusion-operated and intact subgroup for assessment of neuropathology (neurologic deficit scores and infarct volume), brain lipid analysis and brain glutathione levels, respectively.
OLE increased the brain cholesterol ester, cholesterol, cerebroside and phosphatidylcholine levels in doses of 50, 75 and 100mg/kg/day. OLE increased the brain triglyceride levels in doses of 75 and 100mg/kg/day and OLE reduced the brain ceramide levels in doses of 50, 75 and 100mg/kg/day in comparison to the control group (p |
| doi_str_mv | 10.1016/j.phymed.2012.06.003 |
| format | Article |
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Five groups, each consisting of 12 male Wistar rats, were studied. First and second groups (control, and sham) received distilled water, while three treatment groups received oral olive leaf extract (OLE) for 30days (50, 75 and 100mg/kg/day, respectively). Two hours after the last dose, each main group was subdivided to Middle cerebral artery occlusion-operated and intact subgroup for assessment of neuropathology (neurologic deficit scores and infarct volume), brain lipid analysis and brain glutathione levels, respectively.
OLE increased the brain cholesterol ester, cholesterol, cerebroside and phosphatidylcholine levels in doses of 50, 75 and 100mg/kg/day. OLE increased the brain triglyceride levels in doses of 75 and 100mg/kg/day and OLE reduced the brain ceramide levels in doses of 50, 75 and 100mg/kg/day in comparison to the control group (p<0.05).
Although further studies are needed, it seems that the mechanism of OLE-induced ischemic tolerance in rats is partly associated with changes in brain lipids level.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2012.06.003</identifier><identifier>PMID: 22796433</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Animals ; Brain - drug effects ; Brain - metabolism ; Brain ischemia and reperfusion ; Brain lipidomics ; Ceramides - metabolism ; Cholesterol - metabolism ; Disease Models, Animal ; Infarction, Middle Cerebral Artery - drug therapy ; Infarction, Middle Cerebral Artery - metabolism ; Lipid Metabolism - drug effects ; Male ; Neuroprotective Agents - pharmacology ; Neuroprotective Agents - therapeutic use ; Olea ; Olive leaf extract ; Phosphatidylcholines - metabolism ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Leaves ; Rats ; Rats, Wistar ; Stroke - drug therapy ; Stroke - metabolism ; Stroke model</subject><ispartof>Phytomedicine (Stuttgart), 2012-07, Vol.19 (10), p.940-946</ispartof><rights>2012 Elsevier GmbH</rights><rights>Copyright © 2012 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-4d78f76b4253c21709e223befeecab9be79ae359e7a7089c0b88473d843575043</citedby><cites>FETCH-LOGICAL-c419t-4d78f76b4253c21709e223befeecab9be79ae359e7a7089c0b88473d843575043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0944711312002000$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22796433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rabiei, Zahra</creatorcontrib><creatorcontrib>Bigdeli, Mohammad Reza</creatorcontrib><creatorcontrib>Rasoulian, Bahram</creatorcontrib><creatorcontrib>Ghassempour, Alireza</creatorcontrib><creatorcontrib>Mirzajani, Fatemeh</creatorcontrib><title>The neuroprotection effect of pretreatment with olive leaf extract on brain lipidomics in rat stroke model</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>Recent studies suggest that olive extracts suppress inflammation and reduce stress oxidative injury. We have attempted to determine the effect of dietary olive leaf extract (OLE) on brain lipidomics in rat stroke model.
Five groups, each consisting of 12 male Wistar rats, were studied. First and second groups (control, and sham) received distilled water, while three treatment groups received oral olive leaf extract (OLE) for 30days (50, 75 and 100mg/kg/day, respectively). Two hours after the last dose, each main group was subdivided to Middle cerebral artery occlusion-operated and intact subgroup for assessment of neuropathology (neurologic deficit scores and infarct volume), brain lipid analysis and brain glutathione levels, respectively.
OLE increased the brain cholesterol ester, cholesterol, cerebroside and phosphatidylcholine levels in doses of 50, 75 and 100mg/kg/day. OLE increased the brain triglyceride levels in doses of 75 and 100mg/kg/day and OLE reduced the brain ceramide levels in doses of 50, 75 and 100mg/kg/day in comparison to the control group (p<0.05).
Although further studies are needed, it seems that the mechanism of OLE-induced ischemic tolerance in rats is partly associated with changes in brain lipids level.</description><subject>Animals</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain ischemia and reperfusion</subject><subject>Brain lipidomics</subject><subject>Ceramides - metabolism</subject><subject>Cholesterol - metabolism</subject><subject>Disease Models, Animal</subject><subject>Infarction, Middle Cerebral Artery - drug therapy</subject><subject>Infarction, Middle Cerebral Artery - metabolism</subject><subject>Lipid Metabolism - drug effects</subject><subject>Male</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Olea</subject><subject>Olive leaf extract</subject><subject>Phosphatidylcholines - metabolism</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Leaves</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Stroke - drug therapy</subject><subject>Stroke - metabolism</subject><subject>Stroke model</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUQC1ERaeFP0DgJZukfsWON0ioogWpEgtaiZ3lODeMhyQOtqfQv6-jtFtY-Vo-9-F7EHpLSU0JlReHetk_TNDXjFBWE1kTwl-gHZW0rYhufrxEO6KFqBSl_BSdpXQghAqtyCt0ypjSUnC-Q4fbPeAZjjEsMWRw2YcZwzCUCIcBLxFyBJsnmDP-4_Meh9HfAx7BDhj-5mhXbsZdtH7Go198HybvEi63aDNOOYZfgKfQw_ganQx2TPDm6TxHd1efby-_VDffrr9efrqpnKA6V6JX7aBkJ1jDHaOKaGCMdzAAONvpDpS2wBsNyirSake6thWK963gjWqI4Ofow1a3_Oj3EVI2k08OxtHOEI7JUEFZIxmT7P8o4YQ3hEtaULGhLoaUIgxmiX6y8aFAZhViDmYTYlYhhkhThJS0d08djt369pz0bKAA7zdgsMHYn9Enc_e9VJDFlpKNWomPGwFlafceoknOw-yg97FoMn3w_57hEYTiqAM</recordid><startdate>20120715</startdate><enddate>20120715</enddate><creator>Rabiei, Zahra</creator><creator>Bigdeli, Mohammad Reza</creator><creator>Rasoulian, Bahram</creator><creator>Ghassempour, Alireza</creator><creator>Mirzajani, Fatemeh</creator><general>Elsevier GmbH</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20120715</creationdate><title>The neuroprotection effect of pretreatment with olive leaf extract on brain lipidomics in rat stroke model</title><author>Rabiei, Zahra ; Bigdeli, Mohammad Reza ; Rasoulian, Bahram ; Ghassempour, Alireza ; Mirzajani, Fatemeh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-4d78f76b4253c21709e223befeecab9be79ae359e7a7089c0b88473d843575043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain ischemia and reperfusion</topic><topic>Brain lipidomics</topic><topic>Ceramides - metabolism</topic><topic>Cholesterol - metabolism</topic><topic>Disease Models, Animal</topic><topic>Infarction, Middle Cerebral Artery - drug therapy</topic><topic>Infarction, Middle Cerebral Artery - metabolism</topic><topic>Lipid Metabolism - drug effects</topic><topic>Male</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Olea</topic><topic>Olive leaf extract</topic><topic>Phosphatidylcholines - metabolism</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Leaves</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Stroke - drug therapy</topic><topic>Stroke - metabolism</topic><topic>Stroke model</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rabiei, Zahra</creatorcontrib><creatorcontrib>Bigdeli, Mohammad Reza</creatorcontrib><creatorcontrib>Rasoulian, Bahram</creatorcontrib><creatorcontrib>Ghassempour, Alireza</creatorcontrib><creatorcontrib>Mirzajani, Fatemeh</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rabiei, Zahra</au><au>Bigdeli, Mohammad Reza</au><au>Rasoulian, Bahram</au><au>Ghassempour, Alireza</au><au>Mirzajani, Fatemeh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The neuroprotection effect of pretreatment with olive leaf extract on brain lipidomics in rat stroke model</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2012-07-15</date><risdate>2012</risdate><volume>19</volume><issue>10</issue><spage>940</spage><epage>946</epage><pages>940-946</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>Recent studies suggest that olive extracts suppress inflammation and reduce stress oxidative injury. We have attempted to determine the effect of dietary olive leaf extract (OLE) on brain lipidomics in rat stroke model.
Five groups, each consisting of 12 male Wistar rats, were studied. First and second groups (control, and sham) received distilled water, while three treatment groups received oral olive leaf extract (OLE) for 30days (50, 75 and 100mg/kg/day, respectively). Two hours after the last dose, each main group was subdivided to Middle cerebral artery occlusion-operated and intact subgroup for assessment of neuropathology (neurologic deficit scores and infarct volume), brain lipid analysis and brain glutathione levels, respectively.
OLE increased the brain cholesterol ester, cholesterol, cerebroside and phosphatidylcholine levels in doses of 50, 75 and 100mg/kg/day. OLE increased the brain triglyceride levels in doses of 75 and 100mg/kg/day and OLE reduced the brain ceramide levels in doses of 50, 75 and 100mg/kg/day in comparison to the control group (p<0.05).
Although further studies are needed, it seems that the mechanism of OLE-induced ischemic tolerance in rats is partly associated with changes in brain lipids level.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>22796433</pmid><doi>10.1016/j.phymed.2012.06.003</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Brain - drug effects Brain - metabolism Brain ischemia and reperfusion Brain lipidomics Ceramides - metabolism Cholesterol - metabolism Disease Models, Animal Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - metabolism Lipid Metabolism - drug effects Male Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Olea Olive leaf extract Phosphatidylcholines - metabolism Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Leaves Rats Rats, Wistar Stroke - drug therapy Stroke - metabolism Stroke model |
| title | The neuroprotection effect of pretreatment with olive leaf extract on brain lipidomics in rat stroke model |
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