The Role of PAI-1 and Adiponectin on the Inflammatory State and Energy Balance in Obese Adolescents with Metabolic Syndrome
Obesity is a chronic inflammatory disease and is considered a risk factor for metabolic syndrome. In this study, 57 obese adolescents with and without metabolic syndrome underwent 1 year of weight loss therapy. At baseline, the metabolic syndrome (MS) patients presented higher values of PAI-1 than t...
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| Veröffentlicht in: | Inflammation 2012-06, Vol.35 (3), p.944-951 |
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| creator | Corgosinho, Flavia Campos de Piano, Aline Sanches, Priscila L. Campos, Raquel M. Silva, Patricia L. Carnier, June Oyama, Lila M. Tock, Lian Tufik, Sergio de Mello, Marco T. Dâmaso, Ana R. |
| description | Obesity is a chronic inflammatory disease and is considered a risk factor for metabolic syndrome. In this study, 57 obese adolescents with and without metabolic syndrome underwent 1 year of weight loss therapy. At baseline, the metabolic syndrome (MS) patients presented higher values of PAI-1 than the non-metabolic syndrome patients (n-MS). After therapy, significant improvements in anthropometrics and biochemical, inflammatory, and neuroendocrine variables were observed in both groups. However, the n-MS group presented better results than the MS group. Indeed, we found positive correlations in both groups between PAI-1 and neuropeptide Y (NPY) and between PAI-1 and NPY/AgRP. Inflammatory biomarkers may thus play a role in energy balance. The clinical trial registration number is NCT01358773. |
| doi_str_mv | 10.1007/s10753-011-9397-2 |
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In this study, 57 obese adolescents with and without metabolic syndrome underwent 1 year of weight loss therapy. At baseline, the metabolic syndrome (MS) patients presented higher values of PAI-1 than the non-metabolic syndrome patients (n-MS). After therapy, significant improvements in anthropometrics and biochemical, inflammatory, and neuroendocrine variables were observed in both groups. However, the n-MS group presented better results than the MS group. Indeed, we found positive correlations in both groups between PAI-1 and neuropeptide Y (NPY) and between PAI-1 and NPY/AgRP. Inflammatory biomarkers may thus play a role in energy balance. 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In this study, 57 obese adolescents with and without metabolic syndrome underwent 1 year of weight loss therapy. At baseline, the metabolic syndrome (MS) patients presented higher values of PAI-1 than the non-metabolic syndrome patients (n-MS). After therapy, significant improvements in anthropometrics and biochemical, inflammatory, and neuroendocrine variables were observed in both groups. However, the n-MS group presented better results than the MS group. Indeed, we found positive correlations in both groups between PAI-1 and neuropeptide Y (NPY) and between PAI-1 and NPY/AgRP. Inflammatory biomarkers may thus play a role in energy balance. The clinical trial registration number is NCT01358773.</description><subject>Adiponectin - blood</subject><subject>Adiponectin - metabolism</subject><subject>Adiposity</subject><subject>Adolescent</subject><subject>Agouti-Related Protein - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body Composition</subject><subject>Body Mass Index</subject><subject>Energy Metabolism</subject><subject>Exercise</subject><subject>Female</subject><subject>Humans</subject><subject>Immunology</subject><subject>Inflammation - blood</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Metabolic Syndrome - metabolism</subject><subject>Metabolic Syndrome - therapy</subject><subject>Neuropeptide Y - metabolism</subject><subject>Obesity - metabolism</subject><subject>Obesity - therapy</subject><subject>Pathology</subject><subject>Pharmacology/Toxicology</subject><subject>Plasminogen Activator Inhibitor 1 - blood</subject><subject>Plasminogen Activator Inhibitor 1 - metabolism</subject><subject>Rheumatology</subject><subject>Weight Reduction Programs</subject><subject>Young Adult</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0U9rFDEYBvAgil2rH8CLBLx4ib75M8nkuJaqC5WKrechk3mnnTKTrEkWWfzyZt0qIoinHPJ7n7zhIeQ5h9ccwLzJHEwjGXDOrLSGiQdkxRsjmWiMfkhWIDUwaa05IU9yvgOA1rbyMTkRAmQLWq3I9-tbpJ_jjDSO9NN6wzh1YaDrYdrGgL5MgcZAS0WbMM5uWVyJaU-viiv4U54HTDd7-tbNLnik1V_2mLEm1NDsMZRMv03lln7E4vo4T55e7cOQ4oJPyaPRzRmf3Z-n5Mu78-uzD-zi8v3mbH3BvIKmMOs0tD0a6Y33wrhR9MNoERWAt75vlRgM12Zs0EtllPWi1RpAjba3gwElT8mrY-42xa87zKVbprrZXDfGuMsdV1w0WggN_6cAtpFCNW2lL_-id3GXQv3IQbWt1UaKqvhR-RRzTjh22zQtLu0rOjjTHUvsaondocTuMPPiPnnXLzj8nvjVWgXiCHK9CjeY_nz6X6k_AK-3pVw</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Corgosinho, Flavia Campos</creator><creator>de Piano, Aline</creator><creator>Sanches, Priscila L.</creator><creator>Campos, Raquel M.</creator><creator>Silva, Patricia L.</creator><creator>Carnier, June</creator><creator>Oyama, Lila M.</creator><creator>Tock, Lian</creator><creator>Tufik, Sergio</creator><creator>de Mello, Marco T.</creator><creator>Dâmaso, Ana R.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>The Role of PAI-1 and Adiponectin on the Inflammatory State and Energy Balance in Obese Adolescents with Metabolic Syndrome</title><author>Corgosinho, Flavia Campos ; 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In this study, 57 obese adolescents with and without metabolic syndrome underwent 1 year of weight loss therapy. At baseline, the metabolic syndrome (MS) patients presented higher values of PAI-1 than the non-metabolic syndrome patients (n-MS). After therapy, significant improvements in anthropometrics and biochemical, inflammatory, and neuroendocrine variables were observed in both groups. However, the n-MS group presented better results than the MS group. Indeed, we found positive correlations in both groups between PAI-1 and neuropeptide Y (NPY) and between PAI-1 and NPY/AgRP. Inflammatory biomarkers may thus play a role in energy balance. The clinical trial registration number is NCT01358773.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22038064</pmid><doi>10.1007/s10753-011-9397-2</doi><tpages>8</tpages></addata></record> |
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| ispartof | Inflammation, 2012-06, Vol.35 (3), p.944-951 |
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| subjects | Adiponectin - blood Adiponectin - metabolism Adiposity Adolescent Agouti-Related Protein - metabolism Biomedical and Life Sciences Biomedicine Body Composition Body Mass Index Energy Metabolism Exercise Female Humans Immunology Inflammation - blood Internal Medicine Male Metabolic Syndrome - metabolism Metabolic Syndrome - therapy Neuropeptide Y - metabolism Obesity - metabolism Obesity - therapy Pathology Pharmacology/Toxicology Plasminogen Activator Inhibitor 1 - blood Plasminogen Activator Inhibitor 1 - metabolism Rheumatology Weight Reduction Programs Young Adult |
| title | The Role of PAI-1 and Adiponectin on the Inflammatory State and Energy Balance in Obese Adolescents with Metabolic Syndrome |
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