Assessment of Inflammatory and Oxidative Biomarkers in Obesity and Their Associations with Body Mass Index
The aim of this study was to evaluate the inflammatory and oxidative biomarkers’ levels in obese subjects and their associations with body mass index (BMI), in order to investigate the role of these biomarkers in obesity. Fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglyce...
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| Veröffentlicht in: | Inflammation 2013-02, Vol.36 (1), p.226-231 |
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| creator | Piva, Sílvia Juliane Tatsch, Etiane De Carvalho, José Antonio Mainardi Bochi, Guilherme Vargas Kober, Helena Duarte, Thiago Duarte, Marta Maria Medeiros Frescura da Cruz, Ivana Beatrice Mânica Moretto, Maria Beatriz Moresco, Rafael Noal |
| description | The aim of this study was to evaluate the inflammatory and oxidative biomarkers’ levels in obese subjects and their associations with body mass index (BMI), in order to investigate the role of these biomarkers in obesity. Fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, apolipoprotein A, apolipoprotein B, albumin, urinary albumin, creatinine, glomerular filtration rate, interleukin-6 (IL-6), nitrate/nitrite (NOx), and ischemia-modified albumin (IMA) were measured in 93 subjects divided according to different BMI. IL-6, urinary albumin, and IMA levels were significantly higher in obese subjects. However, the levels of NOx were significantly lower in this population. Significant correlations between BMI and IL-6 (
r
= 0.326,
P
= 0.002), NOx (
r
= −0.249,
P
= 0.021), urinary albumin (
r
= 0.270,
P
= 0.008), and IMA (
r
= 0.286,
P
= 0.005) were reported. We have shown an increase of IL-6, urinary albumin, and IMA combined with lower levels of NOx in obese patients and an association between of these biomarkers with BMI, suggesting a possible interplay of oxidative stress, inflammation, and endothelial dysfunction state in obesity. |
| doi_str_mv | 10.1007/s10753-012-9538-2 |
| format | Article |
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r
= 0.326,
P
= 0.002), NOx (
r
= −0.249,
P
= 0.021), urinary albumin (
r
= 0.270,
P
= 0.008), and IMA (
r
= 0.286,
P
= 0.005) were reported. We have shown an increase of IL-6, urinary albumin, and IMA combined with lower levels of NOx in obese patients and an association between of these biomarkers with BMI, suggesting a possible interplay of oxidative stress, inflammation, and endothelial dysfunction state in obesity.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-012-9538-2</identifier><identifier>PMID: 22961567</identifier><identifier>CODEN: INFLD4</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Albuminuria ; Apolipoproteins - blood ; Biomarkers - blood ; Biomedical and Life Sciences ; Biomedicine ; Blood Glucose ; Body Mass Index ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Creatinine - blood ; Female ; Glomerular Filtration Rate ; Humans ; Immunology ; Inflammation - complications ; Interleukin-6 - blood ; Internal Medicine ; Male ; Middle Aged ; Nitric Oxide - blood ; Obesity - blood ; Obesity - complications ; Obesity - physiopathology ; Oxidative Stress ; Pathology ; Pharmacology/Toxicology ; Rheumatology ; Serum Albumin ; Triglycerides - blood</subject><ispartof>Inflammation, 2013-02, Vol.36 (1), p.226-231</ispartof><rights>Springer Science+Business Media, LLC 2012</rights><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-4a0fe4898d7bbe944438bfa1530b3c4a92f4cb7581c78f9c8e7bfc543775eada3</citedby><cites>FETCH-LOGICAL-c405t-4a0fe4898d7bbe944438bfa1530b3c4a92f4cb7581c78f9c8e7bfc543775eada3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10753-012-9538-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10753-012-9538-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22961567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piva, Sílvia Juliane</creatorcontrib><creatorcontrib>Tatsch, Etiane</creatorcontrib><creatorcontrib>De Carvalho, José Antonio Mainardi</creatorcontrib><creatorcontrib>Bochi, Guilherme Vargas</creatorcontrib><creatorcontrib>Kober, Helena</creatorcontrib><creatorcontrib>Duarte, Thiago</creatorcontrib><creatorcontrib>Duarte, Marta Maria Medeiros Frescura</creatorcontrib><creatorcontrib>da Cruz, Ivana Beatrice Mânica</creatorcontrib><creatorcontrib>Moretto, Maria Beatriz</creatorcontrib><creatorcontrib>Moresco, Rafael Noal</creatorcontrib><title>Assessment of Inflammatory and Oxidative Biomarkers in Obesity and Their Associations with Body Mass Index</title><title>Inflammation</title><addtitle>Inflammation</addtitle><addtitle>Inflammation</addtitle><description>The aim of this study was to evaluate the inflammatory and oxidative biomarkers’ levels in obese subjects and their associations with body mass index (BMI), in order to investigate the role of these biomarkers in obesity. Fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, apolipoprotein A, apolipoprotein B, albumin, urinary albumin, creatinine, glomerular filtration rate, interleukin-6 (IL-6), nitrate/nitrite (NOx), and ischemia-modified albumin (IMA) were measured in 93 subjects divided according to different BMI. IL-6, urinary albumin, and IMA levels were significantly higher in obese subjects. However, the levels of NOx were significantly lower in this population. Significant correlations between BMI and IL-6 (
r
= 0.326,
P
= 0.002), NOx (
r
= −0.249,
P
= 0.021), urinary albumin (
r
= 0.270,
P
= 0.008), and IMA (
r
= 0.286,
P
= 0.005) were reported. We have shown an increase of IL-6, urinary albumin, and IMA combined with lower levels of NOx in obese patients and an association between of these biomarkers with BMI, suggesting a possible interplay of oxidative stress, inflammation, and endothelial dysfunction state in obesity.</description><subject>Albuminuria</subject><subject>Apolipoproteins - blood</subject><subject>Biomarkers - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Glucose</subject><subject>Body Mass Index</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Immunology</subject><subject>Inflammation - complications</subject><subject>Interleukin-6 - blood</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nitric Oxide - blood</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Obesity - physiopathology</subject><subject>Oxidative Stress</subject><subject>Pathology</subject><subject>Pharmacology/Toxicology</subject><subject>Rheumatology</subject><subject>Serum Albumin</subject><subject>Triglycerides - blood</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkctu1DAUQC1ERYfCB7BBltiwCfgZx8u24lGpaDbt2nKca-phEhffTOn8PR6lIFQJdeWFzz1-HELecPaBM2Y-ImdGy4Zx0Vgtu0Y8IyuujWyENu1zsmKyZY201hyTl4gbxlhnO_mCHAthW65bsyKbU0RAHGGaaY70YopbP45-zmVP_TTQ9X0a_JzugJ6lPPryAwrSNNF1D5jmhbm6gVRoFeWQKpsnpL_SfEPP8rCn3zxi1Q5w_4ocRb9FeP2wnpDrz5-uzr82l-svF-enl01QTM-N8iyCqhcdTN-DVUrJro-ea8l6GZS3IqrQG93xYLpoQwemj0EraYwGP3h5Qt4v3tuSf-4AZzcmDLDd-gnyDh1XXOiWt0Y9jQojO9YKZSv67hG6ybsy1YccKMG55kJUii9UKBmxQHS3JdVv2zvO3KGZW5q52swdmrnDzNsH864fYfg78SdSBcQCYN2avkP55-j_Wn8Dz0mhZQ</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Piva, Sílvia Juliane</creator><creator>Tatsch, Etiane</creator><creator>De Carvalho, José Antonio Mainardi</creator><creator>Bochi, Guilherme Vargas</creator><creator>Kober, Helena</creator><creator>Duarte, Thiago</creator><creator>Duarte, Marta Maria Medeiros Frescura</creator><creator>da Cruz, Ivana Beatrice Mânica</creator><creator>Moretto, Maria Beatriz</creator><creator>Moresco, Rafael Noal</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>Assessment of Inflammatory and Oxidative Biomarkers in Obesity and Their Associations with Body Mass Index</title><author>Piva, Sílvia Juliane ; Tatsch, Etiane ; De Carvalho, José Antonio Mainardi ; Bochi, Guilherme Vargas ; Kober, Helena ; Duarte, Thiago ; Duarte, Marta Maria Medeiros Frescura ; da Cruz, Ivana Beatrice Mânica ; Moretto, Maria Beatriz ; Moresco, Rafael Noal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-4a0fe4898d7bbe944438bfa1530b3c4a92f4cb7581c78f9c8e7bfc543775eada3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Albuminuria</topic><topic>Apolipoproteins - blood</topic><topic>Biomarkers - blood</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood Glucose</topic><topic>Body Mass Index</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Creatinine - blood</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Immunology</topic><topic>Inflammation - complications</topic><topic>Interleukin-6 - blood</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nitric Oxide - blood</topic><topic>Obesity - blood</topic><topic>Obesity - complications</topic><topic>Obesity - physiopathology</topic><topic>Oxidative Stress</topic><topic>Pathology</topic><topic>Pharmacology/Toxicology</topic><topic>Rheumatology</topic><topic>Serum Albumin</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piva, Sílvia Juliane</creatorcontrib><creatorcontrib>Tatsch, Etiane</creatorcontrib><creatorcontrib>De Carvalho, José Antonio Mainardi</creatorcontrib><creatorcontrib>Bochi, Guilherme Vargas</creatorcontrib><creatorcontrib>Kober, Helena</creatorcontrib><creatorcontrib>Duarte, Thiago</creatorcontrib><creatorcontrib>Duarte, Marta Maria Medeiros Frescura</creatorcontrib><creatorcontrib>da Cruz, Ivana Beatrice Mânica</creatorcontrib><creatorcontrib>Moretto, Maria Beatriz</creatorcontrib><creatorcontrib>Moresco, Rafael Noal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piva, Sílvia Juliane</au><au>Tatsch, Etiane</au><au>De Carvalho, José Antonio Mainardi</au><au>Bochi, Guilherme Vargas</au><au>Kober, Helena</au><au>Duarte, Thiago</au><au>Duarte, Marta Maria Medeiros Frescura</au><au>da Cruz, Ivana Beatrice Mânica</au><au>Moretto, Maria Beatriz</au><au>Moresco, Rafael Noal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of Inflammatory and Oxidative Biomarkers in Obesity and Their Associations with Body Mass Index</atitle><jtitle>Inflammation</jtitle><stitle>Inflammation</stitle><addtitle>Inflammation</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>36</volume><issue>1</issue><spage>226</spage><epage>231</epage><pages>226-231</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><coden>INFLD4</coden><abstract>The aim of this study was to evaluate the inflammatory and oxidative biomarkers’ levels in obese subjects and their associations with body mass index (BMI), in order to investigate the role of these biomarkers in obesity. Fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, apolipoprotein A, apolipoprotein B, albumin, urinary albumin, creatinine, glomerular filtration rate, interleukin-6 (IL-6), nitrate/nitrite (NOx), and ischemia-modified albumin (IMA) were measured in 93 subjects divided according to different BMI. IL-6, urinary albumin, and IMA levels were significantly higher in obese subjects. However, the levels of NOx were significantly lower in this population. Significant correlations between BMI and IL-6 (
r
= 0.326,
P
= 0.002), NOx (
r
= −0.249,
P
= 0.021), urinary albumin (
r
= 0.270,
P
= 0.008), and IMA (
r
= 0.286,
P
= 0.005) were reported. We have shown an increase of IL-6, urinary albumin, and IMA combined with lower levels of NOx in obese patients and an association between of these biomarkers with BMI, suggesting a possible interplay of oxidative stress, inflammation, and endothelial dysfunction state in obesity.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22961567</pmid><doi>10.1007/s10753-012-9538-2</doi><tpages>6</tpages></addata></record> |
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| ispartof | Inflammation, 2013-02, Vol.36 (1), p.226-231 |
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| subjects | Albuminuria Apolipoproteins - blood Biomarkers - blood Biomedical and Life Sciences Biomedicine Blood Glucose Body Mass Index Cholesterol, HDL - blood Cholesterol, LDL - blood Creatinine - blood Female Glomerular Filtration Rate Humans Immunology Inflammation - complications Interleukin-6 - blood Internal Medicine Male Middle Aged Nitric Oxide - blood Obesity - blood Obesity - complications Obesity - physiopathology Oxidative Stress Pathology Pharmacology/Toxicology Rheumatology Serum Albumin Triglycerides - blood |
| title | Assessment of Inflammatory and Oxidative Biomarkers in Obesity and Their Associations with Body Mass Index |
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