$Toll-like Receptor 3 Stimulation Causes Corticosteroid-Refractory Airway Neutrophilia and Hyperresponsiveness in Mice$

Toll-like Receptor 3 Stimulation Causes Corticosteroid-Refractory Airway Neutrophilia and Hyperresponsiveness in Mice

Background RNA virus infections, such as rhinovirus and respiratory syncytial virus, induce exacerbations in patients with COPD and asthma, and the inflammation is corticosteroid refractory. The main aim of this study is to establish a murine model induced by a Toll-like receptor 3 (TLR3) agonist, a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chest 2013-07, Vol.144 (1), p.99-105
Hauptverfasser:	Kimura, Genki, PhD, Ueda, Keitaro, MSc, Eto, Shouichi, MSc, Watanabe, Yuji, MSc, Masuko, Takashi, PhD, Kusama, Tadashi, PhD, Barnes, Peter J., MD, FCCP, Ito, Kazuhiro, DVM, PhD, Kizawa, Yasuo, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Adrenal Cortex Hormones - therapeutic use Androstadienes - therapeutic use Animals Bronchial Hyperreactivity - chemically induced Bronchial Hyperreactivity - drug therapy Bronchial Hyperreactivity - metabolism Chemokine CXCL10 - metabolism Chemokines, CXC - metabolism Dexamethasone - therapeutic use Disease Models, Animal Drug Resistance - drug effects Fluticasone Interferon-beta - metabolism Leukocyte Disorders - chemically induced Leukocyte Disorders - drug therapy Leukocyte Disorders - pathology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Neutrophils - pathology Poly I-C - administration & dosage Poly I-C - adverse effects Poly I-C - pharmacology Pulmonary/Respiratory Toll-Like Receptor 3 - agonists Toll-Like Receptor 3 - physiology Treatment Outcome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!