Fatal association of mechanical valve thrombosis with dabigatran: a report of two cases
Several new oral anticoagulants have been approved for thromboembolism prevention in patients with nonvalvular atrial fibrillation. However, they are not yet approved for anticoagulation use in patients with prosthetic mechanical valves, and no randomized data have been published so far on their saf...
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| Veröffentlicht in: | Chest 2013-07, Vol.144 (1), p.327-328 |
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| container_title | Chest |
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| creator | Atar, Shaul Wishniak, Alice Shturman, Alexander Shtiwi, Sewaed Brezins, Marc |
| description | Several new oral anticoagulants have been approved for thromboembolism prevention in patients with nonvalvular atrial fibrillation. However, they are not yet approved for anticoagulation use in patients with prosthetic mechanical valves, and no randomized data have been published so far on their safety of use in these patients. We present two cases of patients with prosthetic mechanical mitral valves who were switched from warfarin and acenocoumarol to dabigatran and within 1 month experienced severe valve complications resulting in death. One patient experienced stroke and later cardiogenic shock and death, and the other experienced pulmonary edema, cardiogenic shock, and subsequent death. |
| doi_str_mv | 10.1378/chest.12-2486 |
| format | Article |
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| identifier | EISSN: 1931-3543 |
| ispartof | Chest, 2013-07, Vol.144 (1), p.327-328 |
| issn | 1931-3543 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Aged Antithrombins - adverse effects Antithrombins - therapeutic use Atrial Fibrillation - surgery Benzimidazoles - adverse effects Benzimidazoles - therapeutic use beta-Alanine - adverse effects beta-Alanine - analogs & derivatives beta-Alanine - therapeutic use Dabigatran Fatal Outcome Female Heart Valve Prosthesis Humans Mitral Valve Thromboembolism - prevention & control |
| title | Fatal association of mechanical valve thrombosis with dabigatran: a report of two cases |
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