Intramyocardial transfer of hepatocyte growth factor as an adjunct to CABG: phase I clinical study

The purpose of this phase I clinical trial was to evaluate the safety, tolerability and potential efficacy of VM202, naked DNA expressing two isoforms of hepatocyte growth factor, as an adjunct therapy to coronary artery bypass grafting (CABG) in patients with ischemic heart disease (IHD). Nine pati...

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Veröffentlicht in:	Gene therapy 2013-07, Vol.20 (7), p.717-722
Hauptverfasser:	Kim, J S, Hwang, H Y, Cho, K R, Park, E-A, Lee, W, Paeng, J C, Lee, D S, Kim, H-K, Sohn, D-W, Kim, K-B
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308/2779/109/1940 692/699/75 692/700/565/201 Aged Angiogenesis Biomedical and Life Sciences Biomedicine Bypass Cardiovascular disease Care and treatment Cell Biology Clinical trials Computed tomography Coronary artery Coronary Artery Bypass Coronary artery disease Coronary vessels Deoxyribonucleic acid Diagnosis DNA Echocardiography Female Gene Expression Gene Therapy Gene Transfer Techniques Genetic aspects Growth factors Health aspects Heart - diagnostic imaging Heart - physiopathology Heart diseases Heart surgery Hepatocyte growth factor Hepatocyte Growth Factor - genetics Human Genetics Humans Ischemia Isoforms Liver cells Magnetic resonance imaging Male Middle Aged Myocardial Ischemia - genetics Myocardial Ischemia - surgery Myocardial Ischemia - therapy Myocardium Nanotechnology Neovascularization, Physiologic - genetics original-article Patients Perfusion Physiological aspects Radiography Single photon emission computed tomography SPECT imaging Tomography, Emission-Computed, Single-Photon Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Veins & arteries
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