Glutathione S-transferase gene variations influence BU pharmacokinetics and outcome of hematopoietic SCT in pediatric patients

BU is a key compound of conditioning regimens in children undergoing hematopoietic SCT (HSCT). Inter-individual differences in BU pharmacokinetics (PKs) might affect BU efficacy and toxicity. As BU is mainly metabolized by glutathione S -transferase (GST), we investigated the relationship between GS...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2013-07, Vol.48 (7), p.939-946
Hauptverfasser:	Ansari, M, Rezgui, M A, Théoret, Y, Uppugunduri, C R S, Mezziani, S, Vachon, M-F, Desjean, C, Rousseau, J, Labuda, M, Przybyla, C, Duval, M, Champagne, M, Peters, C, Bittencourt, H, Krajinovic, M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/436/1729 631/154/436/434 631/250/1904 692/700/1720 Adult Age Factors Allografts Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Busulfan - administration & dosage Busulfan - pharmacokinetics Cell Biology Child Child, Preschool Children Conditioning Dosage Drug dosages Female Gene Dosage Genetic aspects Genetic factors Genotypes Glutathione Glutathione transferase Glutathione Transferase - genetics Glutathione Transferase - metabolism Graft-versus-host reaction GSTM1 protein Haplotypes Hematology Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Humans Infant Internal Medicine Male Medical sciences Medicine Medicine & Public Health Myeloablative Agonists - administration & dosage Myeloablative Agonists - pharmacokinetics original-article Patients Pediatrics Pharmacokinetics Pharmacology Physiological aspects Public Health Stem cell transplantation Stem Cells Toxicity Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation Conditioning Veno-occlusive disease
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