The effects of caloric restriction on Fetuin-A and cardiovascular risk factors in rats and humans: a randomized controlled trial
Summary Objectives The liver‐secreted protein fetuin‐A is associated with insulin resistance, metabolic syndrome, type 2 diabetes and atherosclerosis. We examined the effect of caloric restriction (CR) on fetuin‐A levels and concomitant changes in hepatic steatosis and cardiovascular risk factors in...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2013-09, Vol.79 (3), p.356-363 |
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| creator | Choi, Kyung Mook Han, Kyung Ah Ahn, Hee Jung Lee, So Young Hwang, Soon Young Kim, Baek-Hui Hong, Ho Cheol Choi, Hae Yoon Yang, Sae Jeong Yoo, Hye Jin Baik, Sei Hyun Choi, Dong Seop Min, Kyung Wan |
| description | Summary
Objectives
The liver‐secreted protein fetuin‐A is associated with insulin resistance, metabolic syndrome, type 2 diabetes and atherosclerosis. We examined the effect of caloric restriction (CR) on fetuin‐A levels and concomitant changes in hepatic steatosis and cardiovascular risk factors in rats and humans.
Design and Subjects
We performed a randomized, controlled clinical trial to examine circulating fetuin‐A levels and cardiovascular risk parameters including visceral fat area (VFA), atherogenic lipid profile, inflammatory markers, adipokines levels and brachial artery endothelial function in 76 overweight women with type 2 diabetes before and after 12 weeks of CR. In addition, the effects of CR on hepatic steatosis and fetuin‐A mRNA expression were evaluated in Otuska Long Evans Tokushima Fatty (OLETF) rats, an animal model of obesity and type 2 diabetes.
Results
Circulating fetuin‐A levels were significantly decreased after 12 weeks of CR and were accompanied by improvements in VFA, blood pressure, glucose, lipid profiles and liver function. The CR group also showed a significant decrease in apolipoprotein B, leptin and insulin resistance compared to those in the control group, although endothelial function was not different. Multiple regression analysis showed that the changes in fetuin‐A levels were independently associated with CR and changes in hsCRP and adiponectin (R2 = 0·156). Moreover, CR significantly reduced hepatic steatosis and fetuin‐A expression, as well as weight, glucose, total cholesterol and triglyceride levels, in OLETF rats.
Conclusion
Caloric restriction significantly reduced the hepatic expression of fetuin‐A and its circulating levels and improved several cardiovascular risk factors in obese rats and humans with type 2 diabetes. |
| doi_str_mv | 10.1111/cen.12076 |
| format | Article |
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Objectives
The liver‐secreted protein fetuin‐A is associated with insulin resistance, metabolic syndrome, type 2 diabetes and atherosclerosis. We examined the effect of caloric restriction (CR) on fetuin‐A levels and concomitant changes in hepatic steatosis and cardiovascular risk factors in rats and humans.
Design and Subjects
We performed a randomized, controlled clinical trial to examine circulating fetuin‐A levels and cardiovascular risk parameters including visceral fat area (VFA), atherogenic lipid profile, inflammatory markers, adipokines levels and brachial artery endothelial function in 76 overweight women with type 2 diabetes before and after 12 weeks of CR. In addition, the effects of CR on hepatic steatosis and fetuin‐A mRNA expression were evaluated in Otuska Long Evans Tokushima Fatty (OLETF) rats, an animal model of obesity and type 2 diabetes.
Results
Circulating fetuin‐A levels were significantly decreased after 12 weeks of CR and were accompanied by improvements in VFA, blood pressure, glucose, lipid profiles and liver function. The CR group also showed a significant decrease in apolipoprotein B, leptin and insulin resistance compared to those in the control group, although endothelial function was not different. Multiple regression analysis showed that the changes in fetuin‐A levels were independently associated with CR and changes in hsCRP and adiponectin (R2 = 0·156). Moreover, CR significantly reduced hepatic steatosis and fetuin‐A expression, as well as weight, glucose, total cholesterol and triglyceride levels, in OLETF rats.
Conclusion
Caloric restriction significantly reduced the hepatic expression of fetuin‐A and its circulating levels and improved several cardiovascular risk factors in obese rats and humans with type 2 diabetes.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.12076</identifier><identifier>PMID: 23067229</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Adipokines - biosynthesis ; Aged ; alpha-2-HS-Glycoprotein - biosynthesis ; Animals ; Biological and medical sciences ; Body Composition ; Caloric Restriction ; Cardiovascular Diseases - prevention & control ; Diabetes Complications - diagnosis ; Diabetes Mellitus, Type 2 - blood ; Endocrinopathies ; Fatty Liver - prevention & control ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Inflammation ; Intra-Abdominal Fat - pathology ; Lipids - blood ; Medical sciences ; Middle Aged ; Overweight ; Rats ; Rats, Long-Evans ; Risk Factors ; Tomography, X-Ray Computed ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2013-09, Vol.79 (3), p.356-363</ispartof><rights>2012 John Wiley & Sons Ltd</rights><rights>2014 INIST-CNRS</rights><rights>2012 John Wiley & Sons Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen.12076$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen.12076$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27605222$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23067229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Kyung Mook</creatorcontrib><creatorcontrib>Han, Kyung Ah</creatorcontrib><creatorcontrib>Ahn, Hee Jung</creatorcontrib><creatorcontrib>Lee, So Young</creatorcontrib><creatorcontrib>Hwang, Soon Young</creatorcontrib><creatorcontrib>Kim, Baek-Hui</creatorcontrib><creatorcontrib>Hong, Ho Cheol</creatorcontrib><creatorcontrib>Choi, Hae Yoon</creatorcontrib><creatorcontrib>Yang, Sae Jeong</creatorcontrib><creatorcontrib>Yoo, Hye Jin</creatorcontrib><creatorcontrib>Baik, Sei Hyun</creatorcontrib><creatorcontrib>Choi, Dong Seop</creatorcontrib><creatorcontrib>Min, Kyung Wan</creatorcontrib><title>The effects of caloric restriction on Fetuin-A and cardiovascular risk factors in rats and humans: a randomized controlled trial</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol</addtitle><description>Summary
Objectives
The liver‐secreted protein fetuin‐A is associated with insulin resistance, metabolic syndrome, type 2 diabetes and atherosclerosis. We examined the effect of caloric restriction (CR) on fetuin‐A levels and concomitant changes in hepatic steatosis and cardiovascular risk factors in rats and humans.
Design and Subjects
We performed a randomized, controlled clinical trial to examine circulating fetuin‐A levels and cardiovascular risk parameters including visceral fat area (VFA), atherogenic lipid profile, inflammatory markers, adipokines levels and brachial artery endothelial function in 76 overweight women with type 2 diabetes before and after 12 weeks of CR. In addition, the effects of CR on hepatic steatosis and fetuin‐A mRNA expression were evaluated in Otuska Long Evans Tokushima Fatty (OLETF) rats, an animal model of obesity and type 2 diabetes.
Results
Circulating fetuin‐A levels were significantly decreased after 12 weeks of CR and were accompanied by improvements in VFA, blood pressure, glucose, lipid profiles and liver function. The CR group also showed a significant decrease in apolipoprotein B, leptin and insulin resistance compared to those in the control group, although endothelial function was not different. Multiple regression analysis showed that the changes in fetuin‐A levels were independently associated with CR and changes in hsCRP and adiponectin (R2 = 0·156). Moreover, CR significantly reduced hepatic steatosis and fetuin‐A expression, as well as weight, glucose, total cholesterol and triglyceride levels, in OLETF rats.
Conclusion
Caloric restriction significantly reduced the hepatic expression of fetuin‐A and its circulating levels and improved several cardiovascular risk factors in obese rats and humans with type 2 diabetes.</description><subject>Adipokines - biosynthesis</subject><subject>Aged</subject><subject>alpha-2-HS-Glycoprotein - biosynthesis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Composition</subject><subject>Caloric Restriction</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Diabetes Complications - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Endocrinopathies</subject><subject>Fatty Liver - prevention & control</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Intra-Abdominal Fat - pathology</subject><subject>Lipids - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Overweight</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Risk Factors</subject><subject>Tomography, X-Ray Computed</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1rFDEUhoModq1e-AckIII30-Zjksx4V5Z2FWpFXPEyZPNB02YmbTKj1it_ume7awVDIIfkeU_OeQ9CLyk5orCOrR-PKCNKPkILyqVoGJPiMVoQTkhDpGwP0LNarwghoiPqKTpgnEjFWL9Av9eXHvsQvJ0qzgFbk3KJFhdfJzinmEcM-8xPcxybE2xGB0xxMX831c7JFFxivcbB2CmXiuOIi4FUW-5yHsxY32EDV6PLQ_zlQZzHqeSUIIQPTHqOngSTqn-xPw_R17PT9fJ9c_5p9WF5ct5E3irZCEGcJL2z7abvvG-N57IPzgTattZL70jPjOoC9x2jYmPABcc7EmSwG6cE44fo7S7vTcm3M3Snh1itT8mMPs9V05YywaTiHNDX_6FXeS4jVKepYL1QYKkA6tWemjeDd_qmxMGUO_3XWwDe7AFwyqQAJthY_3FKEsHYtrLjHfcjJn_38E6J3g5Xw3D1_XD18vTiPgBFs1PEOvmfDwpTrjU0oIT-drHSn9lHxtWXtV7xP1XLpa8</recordid><startdate>201309</startdate><enddate>201309</enddate><creator>Choi, Kyung Mook</creator><creator>Han, Kyung Ah</creator><creator>Ahn, Hee Jung</creator><creator>Lee, So Young</creator><creator>Hwang, Soon Young</creator><creator>Kim, Baek-Hui</creator><creator>Hong, Ho Cheol</creator><creator>Choi, Hae Yoon</creator><creator>Yang, Sae Jeong</creator><creator>Yoo, Hye Jin</creator><creator>Baik, Sei Hyun</creator><creator>Choi, Dong Seop</creator><creator>Min, Kyung Wan</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201309</creationdate><title>The effects of caloric restriction on Fetuin-A and cardiovascular risk factors in rats and humans: a randomized controlled trial</title><author>Choi, Kyung Mook ; Han, Kyung Ah ; Ahn, Hee Jung ; Lee, So Young ; Hwang, Soon Young ; Kim, Baek-Hui ; Hong, Ho Cheol ; Choi, Hae Yoon ; Yang, Sae Jeong ; Yoo, Hye Jin ; Baik, Sei Hyun ; Choi, Dong Seop ; Min, Kyung Wan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3476-550d609dc4b98ee4ae369fdaf144ce6ed092a78f3e8215ba365d380f6fcbd7523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adipokines - biosynthesis</topic><topic>Aged</topic><topic>alpha-2-HS-Glycoprotein - biosynthesis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Composition</topic><topic>Caloric Restriction</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>Diabetes Complications - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Endocrinopathies</topic><topic>Fatty Liver - prevention & control</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Intra-Abdominal Fat - pathology</topic><topic>Lipids - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Overweight</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Risk Factors</topic><topic>Tomography, X-Ray Computed</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Kyung Mook</creatorcontrib><creatorcontrib>Han, Kyung Ah</creatorcontrib><creatorcontrib>Ahn, Hee Jung</creatorcontrib><creatorcontrib>Lee, So Young</creatorcontrib><creatorcontrib>Hwang, Soon Young</creatorcontrib><creatorcontrib>Kim, Baek-Hui</creatorcontrib><creatorcontrib>Hong, Ho Cheol</creatorcontrib><creatorcontrib>Choi, Hae Yoon</creatorcontrib><creatorcontrib>Yang, Sae Jeong</creatorcontrib><creatorcontrib>Yoo, Hye Jin</creatorcontrib><creatorcontrib>Baik, Sei Hyun</creatorcontrib><creatorcontrib>Choi, Dong Seop</creatorcontrib><creatorcontrib>Min, Kyung Wan</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Kyung Mook</au><au>Han, Kyung Ah</au><au>Ahn, Hee Jung</au><au>Lee, So Young</au><au>Hwang, Soon Young</au><au>Kim, Baek-Hui</au><au>Hong, Ho Cheol</au><au>Choi, Hae Yoon</au><au>Yang, Sae Jeong</au><au>Yoo, Hye Jin</au><au>Baik, Sei Hyun</au><au>Choi, Dong Seop</au><au>Min, Kyung Wan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of caloric restriction on Fetuin-A and cardiovascular risk factors in rats and humans: a randomized controlled trial</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol</addtitle><date>2013-09</date><risdate>2013</risdate><volume>79</volume><issue>3</issue><spage>356</spage><epage>363</epage><pages>356-363</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objectives
The liver‐secreted protein fetuin‐A is associated with insulin resistance, metabolic syndrome, type 2 diabetes and atherosclerosis. We examined the effect of caloric restriction (CR) on fetuin‐A levels and concomitant changes in hepatic steatosis and cardiovascular risk factors in rats and humans.
Design and Subjects
We performed a randomized, controlled clinical trial to examine circulating fetuin‐A levels and cardiovascular risk parameters including visceral fat area (VFA), atherogenic lipid profile, inflammatory markers, adipokines levels and brachial artery endothelial function in 76 overweight women with type 2 diabetes before and after 12 weeks of CR. In addition, the effects of CR on hepatic steatosis and fetuin‐A mRNA expression were evaluated in Otuska Long Evans Tokushima Fatty (OLETF) rats, an animal model of obesity and type 2 diabetes.
Results
Circulating fetuin‐A levels were significantly decreased after 12 weeks of CR and were accompanied by improvements in VFA, blood pressure, glucose, lipid profiles and liver function. The CR group also showed a significant decrease in apolipoprotein B, leptin and insulin resistance compared to those in the control group, although endothelial function was not different. Multiple regression analysis showed that the changes in fetuin‐A levels were independently associated with CR and changes in hsCRP and adiponectin (R2 = 0·156). Moreover, CR significantly reduced hepatic steatosis and fetuin‐A expression, as well as weight, glucose, total cholesterol and triglyceride levels, in OLETF rats.
Conclusion
Caloric restriction significantly reduced the hepatic expression of fetuin‐A and its circulating levels and improved several cardiovascular risk factors in obese rats and humans with type 2 diabetes.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>23067229</pmid><doi>10.1111/cen.12076</doi><tpages>8</tpages></addata></record> |
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| subjects | Adipokines - biosynthesis Aged alpha-2-HS-Glycoprotein - biosynthesis Animals Biological and medical sciences Body Composition Caloric Restriction Cardiovascular Diseases - prevention & control Diabetes Complications - diagnosis Diabetes Mellitus, Type 2 - blood Endocrinopathies Fatty Liver - prevention & control Female Fundamental and applied biological sciences. Psychology Humans Inflammation Intra-Abdominal Fat - pathology Lipids - blood Medical sciences Middle Aged Overweight Rats Rats, Long-Evans Risk Factors Tomography, X-Ray Computed Vertebrates: endocrinology |
| title | The effects of caloric restriction on Fetuin-A and cardiovascular risk factors in rats and humans: a randomized controlled trial |
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