Inhibition of queuine uptake in cultured human fibroblasts by phorbol-12,13-didecanoate

The modified base queuine is inserted posttranscriptionally into the first position of the anticodon of tyrosine tRNA, histidine tRNA, asparginine tRNA, and aspartic acid tRNA. Phorbol-12,13-didecanoate (PDD) effects a decrease in the queuine content of tRNA in cultured human foreskin fibroblasts. T...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1985-03, Vol.45 (3), p.1079-1085
Hauptverfasser:	ELLIOTT, M. S, TREWYN, R. W, KATZE, J. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biological Transport - drug effects Carcinogens Cell physiology Cells, Cultured fibroblasts Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Guanine - analogs & derivatives Guanine - metabolism Humans Kinetics man Molecular and cellular biology Phorbol Esters - toxicity phorbol-12,13-didecanoic acid Phorbols - toxicity queuine Responses to growth factors, tumor promotors, other factors RNA, Transfer - metabolism Tritium
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