A Novel Bivalent Vaccine Based on a PB2-Knockout Influenza Virus Protects Mice from Pandemic H1N1 and Highly Pathogenic H5N1 Virus Challenges
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| Veröffentlicht in: | Journal of Virology 2013-07, Vol.87 (14), p.7874-7881 |
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| container_end_page | 7881 |
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| container_issue | 14 |
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| container_title | Journal of Virology |
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| creator | Uraki, Ryuta Kiso, Maki Iwatsuki-Horimoto, Kiyoko Fukuyama, Satoshi Takashita, Emi Ozawa, Makoto Kawaoka, Yoshihiro |
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| doi_str_mv | 10.1128/JVI.00076-13 |
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</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>23658445</pmid><doi>10.1128/JVI.00076-13</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Antibodies, Viral - blood Antibodies, Viral - immunology Blotting, Western Bronchoalveolar Lavage Fluid - immunology Dogs Gene Knockout Techniques HEK293 Cells Humans Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - immunology Influenza Vaccines - genetics Influenza virus Kinetics Madin Darby Canine Kidney Cells Mice Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Plasmids - genetics RNA Replicase - genetics Vaccines and Antiviral Agents Viral Proteins - genetics |
| title | A Novel Bivalent Vaccine Based on a PB2-Knockout Influenza Virus Protects Mice from Pandemic H1N1 and Highly Pathogenic H5N1 Virus Challenges |
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