Sterically stabilized liposomes as a platform for salinomycin metal coordination compounds: physicochemical characterization and in vitro evaluation

Sterically stabilized DPPC:CHOL:DSPE-PEG-2000 liposomal formulations of the lipophilic complexes of salinomycin with Na(I), K(I), Mn(II), Co(II), and Ni(II) ions were prepared by film-hydration method at different drug-to-DPPC molar ratios. For the K(I) and Na(I) complexes, optimal loading was estab...

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Veröffentlicht in:	Journal of drug delivery science and technology 2013-01, Vol.23 (3), p.215-223
Hauptverfasser:	Momekova, D., Momekov, G., Ivanova, J., Pantcheva, I., Drakalska, E., Stoyanov, N., Guenova, M., Michova, A., Balashev, K., Arpadjan, S., Mitewa, M., Rangelov, S., Lambov, N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cytotoxicity Metal complexes Salinomycin Sterically stabilized liposomes
Online-Zugang:	Volltext
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