Mayo prognostic model for WHO-defined chronic myelomonocytic leukemia: ASXL1 and spliceosome component mutations and outcomes

We evaluated the prognostic relevance of several clinical and laboratory parameters in 226 Mayo Clinic patients with chronic myelomonocytic leukemia (CMML): 152 (67%) males and median age 71 years. At a median follow-up of 15 months, 166 (73%) deaths and 33 (14.5%) leukemic transformations were docu...

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Veröffentlicht in:	Leukemia 2013-07, Vol.27 (7), p.1504-1510
Hauptverfasser:	Patnaik, M M, Padron, E, LaBorde, R R, Lasho, T L, Finke, C M, Hanson, C A, Hodnefield, J M, Knudson, R A, Ketterling, R P, Al-kali, A, Pardanani, A, Ali, N A, Komroji, R S, Tefferi, A
Format:	Artikel
Sprache:	eng
Schlagworte:	692/699/67/1990/283 692/700/1750 692/700/1750/1976 Adult Aged Aged, 80 and over Anemia Anemia - mortality Blood Blood circulation Bone marrow Cancer Research Chromosomes Chronic myelomonocytic leukemia Cohort Studies Confidence intervals Critical Care Medicine Female Follow-Up Studies Gene mutations Genetic aspects Hematology Hemoglobin Humans Impact analysis Intensive Internal Medicine Leukemia Leukemia, Myelomonocytic, Chronic - genetics Leukemia, Myelomonocytic, Chronic - mortality Leukocytes Leukocytes (neutrophilic) Lymphocyte Count Lymphocytes Male Medical prognosis Medicine Medicine & Public Health Middle Aged Models, Statistical Monocytes Mutation Myeloid cells Myelomonocytic leukemia Nuclear Proteins - genetics Oncology original-article Patient outcomes Patients Peripheral blood Phosphoproteins - genetics Physiological aspects Prognosis Repressor Proteins - genetics Ribonucleoprotein, U2 Small Nuclear - genetics Ribonucleoproteins - genetics Risk analysis Risk Factors RNA Splicing Factors Serine-Arginine Splicing Factors Spliceosomes Spliceosomes - genetics Splicing Factor U2AF Survival Survival Analysis Thrombocytopenia Thrombocytopenia - mortality World Health Organization Young Adult
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