Peri-aortic fat tissue and malnutrition-inflammation-atherosclerosis/calcificati on syndrome in end-stage renal disease patients

Purpose: Thoracic peri-aortic fat tissue (PFT) is considered as a metabolically active organ in atherosclerosis. Malnutrition, inflammation and atherosclerosis/calcification (MIAC) are the most commonly encountered risk factors of cardiovascular disease in end-stage renal disease (ESRD) patients. Ca...

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Veröffentlicht in:International urology and nephrology 2013-06, Vol.45 (3), p.857-867
Hauptverfasser: Turkmen, K, Tonbul, H Z, Erdur, F M, Guney, I, Kayikcioglu, H, Altintepe, L, Ozbek, O, Yilmaz, MI, Gaipov, A, Turk, S, Covic, A, Kanbay, M
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container_end_page 867
container_issue 3
container_start_page 857
container_title International urology and nephrology
container_volume 45
creator Turkmen, K
Tonbul, H Z
Erdur, F M
Guney, I
Kayikcioglu, H
Altintepe, L
Ozbek, O
Yilmaz, MI
Gaipov, A
Turk, S
Covic, A
Kanbay, M
description Purpose: Thoracic peri-aortic fat tissue (PFT) is considered as a metabolically active organ in atherosclerosis. Malnutrition, inflammation and atherosclerosis/calcification (MIAC) are the most commonly encountered risk factors of cardiovascular disease in end-stage renal disease (ESRD) patients. Calcification of the aorta was found to be an important cardiovascular risk marker predicting future events, morbidity and mortality in this population. We aimed to investigate the relationship between PFT, MIAC syndrome and thoracic aortic calcification (TAC) in ESRD patients. Methods: Seventy-nine ESRD patients receiving hemodialysis (HD) or peritoneal dialysis (PD) and 20 control subjects were enrolled in this cross-sectional study. PFT and TAC were assessed using a 64-MDCT scanner. Patients with serum albumin 10 mg/L had inflammation, and those with coronary artery calcification score (CACS) >10 had atherosclerosis/calcification. Results: TAC and PFT were significantly higher in ESRD patients compared with control subjects. There was a statistically significant relationship between PFT and TAC in ESRD patients (r = 0.458, p < 0.0001). PFT was found to be significantly increased when the MIAC components increased. PFT was positively associated with age, BMI, uric acid, hemoglobin and CAC. The multivariate analysis revealed that age and uric acid were independent predictors of increased PFT. Twenty-four (30.4 %) patients had none, 30 (37.9 %) had one component, 17 (21.5 %) had two components, and 8 (10.2 %) had all MIAC components. PFT was highest among patients having all three components (28.6 cm super(3)) and lowest among those who do not have the MIAC syndrome (8.54 cm super(3)). TAC was highest among patients having all three components (179.2 HU) and lowest among those who do not have the MIAC syndrome (0 HU). Conclusions: We found a relationship between PFT and MIAC syndrome in ESRD patients.
doi_str_mv 10.1007/s11255-012-0286-x
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Malnutrition, inflammation and atherosclerosis/calcification (MIAC) are the most commonly encountered risk factors of cardiovascular disease in end-stage renal disease (ESRD) patients. Calcification of the aorta was found to be an important cardiovascular risk marker predicting future events, morbidity and mortality in this population. We aimed to investigate the relationship between PFT, MIAC syndrome and thoracic aortic calcification (TAC) in ESRD patients. Methods: Seventy-nine ESRD patients receiving hemodialysis (HD) or peritoneal dialysis (PD) and 20 control subjects were enrolled in this cross-sectional study. PFT and TAC were assessed using a 64-MDCT scanner. Patients with serum albumin &lt;3.5 g/dL were defined as patients with malnutrition; those with serum C-reactive protein level &gt;10 mg/L had inflammation, and those with coronary artery calcification score (CACS) &gt;10 had atherosclerosis/calcification. Results: TAC and PFT were significantly higher in ESRD patients compared with control subjects. There was a statistically significant relationship between PFT and TAC in ESRD patients (r = 0.458, p &lt; 0.0001). PFT was found to be significantly increased when the MIAC components increased. PFT was positively associated with age, BMI, uric acid, hemoglobin and CAC. The multivariate analysis revealed that age and uric acid were independent predictors of increased PFT. Twenty-four (30.4 %) patients had none, 30 (37.9 %) had one component, 17 (21.5 %) had two components, and 8 (10.2 %) had all MIAC components. PFT was highest among patients having all three components (28.6 cm super(3)) and lowest among those who do not have the MIAC syndrome (8.54 cm super(3)). TAC was highest among patients having all three components (179.2 HU) and lowest among those who do not have the MIAC syndrome (0 HU). Conclusions: We found a relationship between PFT and MIAC syndrome in ESRD patients.</description><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-012-0286-x</identifier><language>eng</language><ispartof>International urology and nephrology, 2013-06, Vol.45 (3), p.857-867</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Turkmen, K</creatorcontrib><creatorcontrib>Tonbul, H Z</creatorcontrib><creatorcontrib>Erdur, F M</creatorcontrib><creatorcontrib>Guney, I</creatorcontrib><creatorcontrib>Kayikcioglu, H</creatorcontrib><creatorcontrib>Altintepe, L</creatorcontrib><creatorcontrib>Ozbek, O</creatorcontrib><creatorcontrib>Yilmaz, MI</creatorcontrib><creatorcontrib>Gaipov, A</creatorcontrib><creatorcontrib>Turk, S</creatorcontrib><creatorcontrib>Covic, A</creatorcontrib><creatorcontrib>Kanbay, M</creatorcontrib><title>Peri-aortic fat tissue and malnutrition-inflammation-atherosclerosis/calcificati on syndrome in end-stage renal disease patients</title><title>International urology and nephrology</title><description>Purpose: Thoracic peri-aortic fat tissue (PFT) is considered as a metabolically active organ in atherosclerosis. Malnutrition, inflammation and atherosclerosis/calcification (MIAC) are the most commonly encountered risk factors of cardiovascular disease in end-stage renal disease (ESRD) patients. Calcification of the aorta was found to be an important cardiovascular risk marker predicting future events, morbidity and mortality in this population. We aimed to investigate the relationship between PFT, MIAC syndrome and thoracic aortic calcification (TAC) in ESRD patients. Methods: Seventy-nine ESRD patients receiving hemodialysis (HD) or peritoneal dialysis (PD) and 20 control subjects were enrolled in this cross-sectional study. PFT and TAC were assessed using a 64-MDCT scanner. Patients with serum albumin &lt;3.5 g/dL were defined as patients with malnutrition; those with serum C-reactive protein level &gt;10 mg/L had inflammation, and those with coronary artery calcification score (CACS) &gt;10 had atherosclerosis/calcification. Results: TAC and PFT were significantly higher in ESRD patients compared with control subjects. There was a statistically significant relationship between PFT and TAC in ESRD patients (r = 0.458, p &lt; 0.0001). PFT was found to be significantly increased when the MIAC components increased. PFT was positively associated with age, BMI, uric acid, hemoglobin and CAC. The multivariate analysis revealed that age and uric acid were independent predictors of increased PFT. Twenty-four (30.4 %) patients had none, 30 (37.9 %) had one component, 17 (21.5 %) had two components, and 8 (10.2 %) had all MIAC components. PFT was highest among patients having all three components (28.6 cm super(3)) and lowest among those who do not have the MIAC syndrome (8.54 cm super(3)). TAC was highest among patients having all three components (179.2 HU) and lowest among those who do not have the MIAC syndrome (0 HU). 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Malnutrition, inflammation and atherosclerosis/calcification (MIAC) are the most commonly encountered risk factors of cardiovascular disease in end-stage renal disease (ESRD) patients. Calcification of the aorta was found to be an important cardiovascular risk marker predicting future events, morbidity and mortality in this population. We aimed to investigate the relationship between PFT, MIAC syndrome and thoracic aortic calcification (TAC) in ESRD patients. Methods: Seventy-nine ESRD patients receiving hemodialysis (HD) or peritoneal dialysis (PD) and 20 control subjects were enrolled in this cross-sectional study. PFT and TAC were assessed using a 64-MDCT scanner. Patients with serum albumin &lt;3.5 g/dL were defined as patients with malnutrition; those with serum C-reactive protein level &gt;10 mg/L had inflammation, and those with coronary artery calcification score (CACS) &gt;10 had atherosclerosis/calcification. Results: TAC and PFT were significantly higher in ESRD patients compared with control subjects. There was a statistically significant relationship between PFT and TAC in ESRD patients (r = 0.458, p &lt; 0.0001). PFT was found to be significantly increased when the MIAC components increased. PFT was positively associated with age, BMI, uric acid, hemoglobin and CAC. The multivariate analysis revealed that age and uric acid were independent predictors of increased PFT. Twenty-four (30.4 %) patients had none, 30 (37.9 %) had one component, 17 (21.5 %) had two components, and 8 (10.2 %) had all MIAC components. PFT was highest among patients having all three components (28.6 cm super(3)) and lowest among those who do not have the MIAC syndrome (8.54 cm super(3)). TAC was highest among patients having all three components (179.2 HU) and lowest among those who do not have the MIAC syndrome (0 HU). Conclusions: We found a relationship between PFT and MIAC syndrome in ESRD patients.</abstract><doi>10.1007/s11255-012-0286-x</doi></addata></record>
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