Molecular mechanisms of biomaterial-driven osteogenic differentiation in human mesenchymal stromal cells

Calcium phosphate (CaP) based ceramics are used as bone graft substitutes in the treatment of bone defects. The physico-chemical properties of these materials determine their bioactivity, meaning that molecular and cellular responses in the body will be tuned accordingly. In a previous study, we com...

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Veröffentlicht in:	Integrative biology (Cambridge) 2013-07, Vol.5 (7), p.920-931
Hauptverfasser:	Barradas, Ana M C, Monticone, Veronica, Hulsman, Marc, Danoux, Charlène, Fernandes, Hugo, Tahmasebi Birgani, Zeinab, Barrère-de Groot, Florence, Yuan, Huipin, Reinders, Marcel, Habibovic, Pamela, van Blitterswijk, Clemens, de Boer, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatible Materials - pharmacology Bone grafts Calcium Phosphates - pharmacology Cell Differentiation - drug effects Cell Differentiation - genetics Cell Differentiation - physiology Collagen Type I - biosynthesis Collagen Type I - genetics Humans Integrin-Binding Sialoprotein - biosynthesis Integrin-Binding Sialoprotein - genetics Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Microscopy, Electron, Scanning Oligonucleotide Array Sequence Analysis Osteocalcin - biosynthesis Osteocalcin - genetics Osteogenesis - drug effects Osteogenesis - genetics Osteopontin - biosynthesis Osteopontin - genetics RNA - chemistry RNA - genetics Spectroscopy, Fourier Transform Infrared Tissue Engineering - methods
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