Reduced Serum Selenium Concentration in Miscarriage Incidence of Indonesian Subjects
Selenium is an essential nutrient for human health, and maternal selenium concentration has been reported to be associated with pregnancy outcome. To further investigate the possible role of selenium (Se) in miscarriage, we conducted a case–control study to evaluate the correlations among selenium s...
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| Veröffentlicht in: | Biological trace element research 2013-07, Vol.154 (1), p.1-6 |
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| creator | Abdulah, Rizky Noerjasin, Herlambang Septiani, Leri Mutakin Defi, Irma R Suradji, Eka W Puspitasari, Irma M Barliana, Melisa I Yamazaki, Chiho Nakazawa, Minato Koyama, Hiroshi |
| description | Selenium is an essential nutrient for human health, and maternal selenium concentration has been reported to be associated with pregnancy outcome. To further investigate the possible role of selenium (Se) in miscarriage, we conducted a case–control study to evaluate the correlations among selenium status, glutathione peroxidase activity, and spontaneous abortion. A total of 46 subjects with normal pregnancies and 25 subjects with spontaneous abortion were recruited, and their serum selenium concentrations and serum glutathione peroxidase activities were analyzed. The total serum selenium concentrations in subjects with normal pregnancies were significantly higher than those of subjects with spontaneous abortion; however, the glutathione peroxidase activities were similar in both groups. We further separated the subjects into smoking and nonsmoking groups, and the logistic regression analysis suggested that total serum selenium concentration, but not serum glutathione peroxidase activity or smoking, was significantly correlated with the incidence of miscarriage. The present study thus reaffirms that low serum selenium levels are associated with miscarriage and that selenium plays an important role in pregnancy maintenance. |
| doi_str_mv | 10.1007/s12011-013-9701-0 |
| format | Article |
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To further investigate the possible role of selenium (Se) in miscarriage, we conducted a case–control study to evaluate the correlations among selenium status, glutathione peroxidase activity, and spontaneous abortion. A total of 46 subjects with normal pregnancies and 25 subjects with spontaneous abortion were recruited, and their serum selenium concentrations and serum glutathione peroxidase activities were analyzed. The total serum selenium concentrations in subjects with normal pregnancies were significantly higher than those of subjects with spontaneous abortion; however, the glutathione peroxidase activities were similar in both groups. We further separated the subjects into smoking and nonsmoking groups, and the logistic regression analysis suggested that total serum selenium concentration, but not serum glutathione peroxidase activity or smoking, was significantly correlated with the incidence of miscarriage. The present study thus reaffirms that low serum selenium levels are associated with miscarriage and that selenium plays an important role in pregnancy maintenance.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-013-9701-0</identifier><identifier>PMID: 23695728</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>abortion (animals) ; Abortion, Spontaneous - blood ; Abortion, Spontaneous - enzymology ; Adult ; Antioxidants ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; blood serum ; Case-Control Studies ; Enzymes ; Female ; glutathione peroxidase ; Glutathione Peroxidase - blood ; Humans ; Indonesia ; Life Sciences ; Miscarriage ; Nutrient concentrations ; Nutrition ; Oncology ; Pregnancy ; pregnancy outcome ; Regression analysis ; Selenium ; Selenium - blood ; Smoking - adverse effects</subject><ispartof>Biological trace element research, 2013-07, Vol.154 (1), p.1-6</ispartof><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-39b071bc4a464f59c43a2b2ba60631a76970f7213ab7d803e53ba274aa1ef14e3</citedby><cites>FETCH-LOGICAL-c429t-39b071bc4a464f59c43a2b2ba60631a76970f7213ab7d803e53ba274aa1ef14e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-013-9701-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-013-9701-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23695728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdulah, Rizky</creatorcontrib><creatorcontrib>Noerjasin, Herlambang</creatorcontrib><creatorcontrib>Septiani, Leri</creatorcontrib><creatorcontrib>Mutakin</creatorcontrib><creatorcontrib>Defi, Irma R</creatorcontrib><creatorcontrib>Suradji, Eka W</creatorcontrib><creatorcontrib>Puspitasari, Irma M</creatorcontrib><creatorcontrib>Barliana, Melisa I</creatorcontrib><creatorcontrib>Yamazaki, Chiho</creatorcontrib><creatorcontrib>Nakazawa, Minato</creatorcontrib><creatorcontrib>Koyama, Hiroshi</creatorcontrib><title>Reduced Serum Selenium Concentration in Miscarriage Incidence of Indonesian Subjects</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>Selenium is an essential nutrient for human health, and maternal selenium concentration has been reported to be associated with pregnancy outcome. To further investigate the possible role of selenium (Se) in miscarriage, we conducted a case–control study to evaluate the correlations among selenium status, glutathione peroxidase activity, and spontaneous abortion. A total of 46 subjects with normal pregnancies and 25 subjects with spontaneous abortion were recruited, and their serum selenium concentrations and serum glutathione peroxidase activities were analyzed. The total serum selenium concentrations in subjects with normal pregnancies were significantly higher than those of subjects with spontaneous abortion; however, the glutathione peroxidase activities were similar in both groups. We further separated the subjects into smoking and nonsmoking groups, and the logistic regression analysis suggested that total serum selenium concentration, but not serum glutathione peroxidase activity or smoking, was significantly correlated with the incidence of miscarriage. The present study thus reaffirms that low serum selenium levels are associated with miscarriage and that selenium plays an important role in pregnancy maintenance.</description><subject>abortion (animals)</subject><subject>Abortion, Spontaneous - blood</subject><subject>Abortion, Spontaneous - enzymology</subject><subject>Adult</subject><subject>Antioxidants</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>blood serum</subject><subject>Case-Control Studies</subject><subject>Enzymes</subject><subject>Female</subject><subject>glutathione peroxidase</subject><subject>Glutathione Peroxidase - blood</subject><subject>Humans</subject><subject>Indonesia</subject><subject>Life Sciences</subject><subject>Miscarriage</subject><subject>Nutrient concentrations</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Pregnancy</subject><subject>pregnancy outcome</subject><subject>Regression analysis</subject><subject>Selenium</subject><subject>Selenium - 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Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdulah, Rizky</au><au>Noerjasin, Herlambang</au><au>Septiani, Leri</au><au>Mutakin</au><au>Defi, Irma R</au><au>Suradji, Eka W</au><au>Puspitasari, Irma M</au><au>Barliana, Melisa I</au><au>Yamazaki, Chiho</au><au>Nakazawa, Minato</au><au>Koyama, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced Serum Selenium Concentration in Miscarriage Incidence of Indonesian Subjects</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>154</volume><issue>1</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>Selenium is an essential nutrient for human health, and maternal selenium concentration has been reported to be associated with pregnancy outcome. To further investigate the possible role of selenium (Se) in miscarriage, we conducted a case–control study to evaluate the correlations among selenium status, glutathione peroxidase activity, and spontaneous abortion. A total of 46 subjects with normal pregnancies and 25 subjects with spontaneous abortion were recruited, and their serum selenium concentrations and serum glutathione peroxidase activities were analyzed. The total serum selenium concentrations in subjects with normal pregnancies were significantly higher than those of subjects with spontaneous abortion; however, the glutathione peroxidase activities were similar in both groups. We further separated the subjects into smoking and nonsmoking groups, and the logistic regression analysis suggested that total serum selenium concentration, but not serum glutathione peroxidase activity or smoking, was significantly correlated with the incidence of miscarriage. The present study thus reaffirms that low serum selenium levels are associated with miscarriage and that selenium plays an important role in pregnancy maintenance.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>23695728</pmid><doi>10.1007/s12011-013-9701-0</doi><tpages>6</tpages></addata></record> |
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| subjects | abortion (animals) Abortion, Spontaneous - blood Abortion, Spontaneous - enzymology Adult Antioxidants Biochemistry Biomedical and Life Sciences Biotechnology blood serum Case-Control Studies Enzymes Female glutathione peroxidase Glutathione Peroxidase - blood Humans Indonesia Life Sciences Miscarriage Nutrient concentrations Nutrition Oncology Pregnancy pregnancy outcome Regression analysis Selenium Selenium - blood Smoking - adverse effects |
| title | Reduced Serum Selenium Concentration in Miscarriage Incidence of Indonesian Subjects |
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