Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodelling

Ageing is an important risk factor of cardiovascular diseases including heart failure. Senescence marker protein 30 (SMP30), which was originally identified as an important ageing marker protein, is assumed to act as a novel anti-ageing factor in various organs. However, the role of SMP30 in the hea...

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Veröffentlicht in:	Cardiovascular research 2013-08, Vol.99 (3), p.461-470
Hauptverfasser:	Misaka, Tomofumi, Suzuki, Satoshi, Miyata, Makiko, Kobayashi, Atsushi, Shishido, Tetsuro, Ishigami, Akihito, Saitoh, Shu-ichi, Hirose, Masamichi, Kubota, Isao, Takeishi, Yasuchika
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Aging - pathology Angiotensin II - administration & dosage Angiotensin II - metabolism Animals Apoptosis Ascorbic Acid - metabolism bcl-2-Associated X Protein - metabolism Biomarkers - metabolism Calcium-Binding Proteins - deficiency Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cardiomegaly - etiology Cardiomegaly - metabolism Cardiomegaly - pathology Caspase 3 - metabolism Disease Models, Animal Fibrosis Heart Failure - etiology Heart Failure - metabolism Heart Failure - pathology Intracellular Signaling Peptides and Proteins - deficiency Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Myocardium - metabolism Oxidative Stress Proto-Oncogene Proteins c-bcl-2 - metabolism Signal Transduction Ventricular Remodeling - physiology
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